About: Nicorandil, a K(ATP) Channel Opener, Attenuates Ischemia–Reperfusion Injury in Isolated Rat Lungs

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About: Nicorandil, a K(ATP) Channel Opener, Attenuates Ischemia–Reperfusion Injury in Isolated Rat Lungs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nicorandil, a K(ATP) Channel Opener, Attenuates Ischemia–Reperfusion Injury in Isolated Rat Lungs
Creator	Abe, Kyoko Enzan, Keiji Horiguchi, Takashi Kimura, · Masaki, Yoko Nishikawa, ·
Source	PMC
abstract	PURPOSE: Nicorandil is a hybrid between nitrates and K(ATP) channel opener activators. The aim of this study was to evaluate the nicorandil’s effects on ischemia–reperfusion (IR) lung injury and examine the mechanism of its effects. METHODS: Isolated rat lungs were divided into 6 groups. In the sham group, the lungs were perfused and ventilated for 150 min. In the IR group, after perfusion and ventilation for 30 min, they were interrupted (ischemia) for 60 min, and then resumed for 60 min. In the nicorandil (N) + IR group, nicorandil 6 mg was added before ischemia (nicorandil concentration was 75 µg ml(−1)). In the glibenclamide + N + IR group, the L-NAME (N(ω)-Nitro-l-arginine methyl ester) + N + IR group and ODQ (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one) + N + IR group, glibenclamide 3 µM, L-NAME 100 µM, and ODQ 30 µM were added 5 min before nicorandil administration, respectively. We measured the coefficient of filtration (Kfc) of the lungs, total pulmonary vascular resistance, and the wet-to-dry lung weight ratio (WW/DW ratio). RESULTS: Kfc was significantly increased after 60 min reperfusion compared with baseline in the IR group, but no change in the sham group. An increase in Kfc was inhibited in the N + IR group compared with the IR group (0.92 ± 0.28 vs. 2.82 ± 0.68 ml min(−1) mmHg(−1) 100 g(−1); P < 0.01). Also, nicorandil attenuated WW/DW ratio was compared with IR group (8.3 ± 0.41 vs. 10.9 ± 2.5; P < 0.05). Nicorandil’s inhibitory effect was blocked by glibenclamide and ODQ (P < 0.01), but not by L-NAME. CONCLUSIONS: Nicorandil attenuated IR injury in isolated rat lungs. This protective effect appears to involve its activation as K(ATP) channel opener as well as that of the sGC-cGMP pathway.
has issue date	2020-02-21(xsd:dateTime)
bibo:doi	10.1007/s00408-020-00339-0
bibo:pmid	32086560
has license	no-cc
sha1sum (hex)	a455e92e46ed6d4cf1ba3ae3f114c1bce1112469
schema:url	https://doi.org/10.1007/s00408-020-00339-0
resource representing a document's title	Nicorandil, a K(ATP) Channel Opener, Attenuates Ischemia–Reperfusion Injury in Isolated Rat Lungs
has PubMed Central identifier	PMC7223246
has PubMed identifier	32086560
schema:publication	Lung
resource representing a document's body	covid:a455e92e46ed6d4cf1ba3ae3f114c1bce1112469#body_text
is schema:about of	named entity 'Nicorandil' named entity 'group' named entity 'interrupted' named entity 'ratio' named entity 'Injury' named entity 'L-ARGININE' named entity 'EFFECTS' named entity 'min' named entity 'activators' named entity 'coefficient' named entity 'weight' named entity 'study' named entity 'ischemia' named entity 'group' named entity 'sham' named entity 'perfusion' named entity 'evaluate' named entity 'Methods' named entity 'lungs' named entity 'Kfc' named entity 'perfused' named entity 'groups' named entity 'group' named entity 'rat' named entity 'rat' named entity 'nicorandil' named entity 'ischemia-reperfusion' named entity 'nicorandil' named entity 'ischemia' named entity 'methyl ester' named entity 'nicorandil' named entity 'lungs' named entity 'Nicorandil' named entity 'ischemia' named entity 'perfusion' named entity 'nicorandil' named entity 'ratio' named entity 'inhibitory' named entity 'pulmonary capillary' named entity 'sodium pentobarbital' named entity 'endothelial cells' named entity 'perfusion' named entity 'weight gain' named entity 'pulmonary arterial pressure' named entity 'perfusion' named entity 'sample size' named entity 'long-term' named entity 'glibenclamide' named entity 'base excess' named entity 'Nicorandil' named entity 'lung tissue' named entity 'nicorandil' named entity 'nitrate' named entity 'nicorandil' named entity 'dextrose' named entity 'nicorandil' named entity '0.01' named entity 'ODQ' named entity 'lung transplantation' named entity 'endothelium' named entity 'glibenclamide' named entity 'vasodilators' named entity 'proteases' named entity 'microvascular permeability' named entity 'endothelial cells' named entity 'sodium nitroprusside' named entity '0.01' named entity 'nicorandil' named entity 'perfusion' named entity 'rat' named entity 'rat' named entity 'endothelial' named entity '0.01' named entity 'St. Louis' named entity 'microvascular permeability' named entity 'wet weight'

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