About: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details

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About: A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details
Creator	Sellner, Johann Akhvlediani, Tamar Azorín, David Bernard-Valnet, Raphaël Faan, Mba Fean, Fana Jelcic, Ilijas Mancinelli, Luca Monaco, Salvatore Romoli, Michele
Source	Medline; PMC
abstract	BACKGROUND: We systematically reviewed available evidence for reports of neurological signs and symptoms in Coronavirus disease (COVID)‐19 patients to identify cases with severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection or immune‐mediated reaction in the nervous system. METHODS: We followed PRISMA guidelines and used the MEDLINE, EMBASE, Google Scholar, MedRxiv and ChinaXiv databases to search for papers on COVID‐19 and nervous system involvement which were published from January 1(st) to April 24(th) 2020. Data on design, sample size, neurologic assessment and related work‐up were extracted. Biases were assessed with the Newcastle‐Ottawa scale. RESULTS: We analysed 27 publications on potential neuroinvasive or parainfectious neurological complications of COVID‐19. The reports focused on smell and taste (n=5) and evaluation of neurological symptoms and signs in cohorts (n=5). There were cases of Guillain‐Barré syndrome/Miller‐Fisher syndrome/cranial neuropathy (7 cases), meningitis/encephalitis (9 cases) and various other conditions (5 cases). Patients with cerebrospinal fluid (CSF) examination and in particular SARS‐CoV‐2 PCR was negligible. Amongst, two had a positive SARS‐CoV‐2 PCR exam of CSF specimen. The study of potential parenchymal involvement with magnetic resonance imaging was rare. Only 4 reports received a rating for the highest quality standards. CONCLUSION: This systematic review failed to establish comprehensive insights to nervous system manifestations of COVID‐19 beyond immune‐mediated complications as aftermath of respiratory symptoms. The authors therefore provide guidance for more careful clinical, diagnostic and epidemiological studies to characterize the manifestations and burden of neurological disease caused by SARS‐CoV‐2 on behalf of the Infectious Disease Panel of the European Academy of Neurology.
has issue date	2020-06-05(xsd:dateTime)
bibo:doi	10.1111/ene.14382
bibo:pmid	32503088
has license	no-cc
sha1sum (hex)	a42282401b6549e560d5e7736ca054afb2ff9021
schema:url	https://doi.org/10.1111/ene.14382
resource representing a document's title	A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details
has PubMed Central identifier	PMC7300895
has PubMed identifier	32503088
schema:publication	Eur J Neurol
resource representing a document's body	covid:a42282401b6549e560d5e7736ca054afb2ff9021#body_text
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