About: Development of nonhuman adenoviruses as vaccine vectors

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Development of nonhuman adenoviruses as vaccine vectors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Development of nonhuman adenoviruses as vaccine vectors
Creator	Mittal, Suresh Bangari, Dinesh
Source	Elsevier; Medline; PMC
abstract	Human adenoviral (HAd) vectors have demonstrated great potential as vaccine vectors. Preclinical and clinical studies have demonstrated the feasibility of vector design, robust antigen expression and protective immunity using this system. However, clinical use of adenoviral vectors for vaccine purposes is anticipated to be limited by vector immunity that is either preexisting or develops rapidly following the first inoculation with adenoviral vectors. Vector immunity inactivates the vector particles and rapidly removes the transduced cells, thereby limiting the duration of transgene expression. Due to strong vector immunity, subsequent use of the same vector is usually less efficient. In order to circumvent this limitation, nonhuman adenoviral vectors have been proposed as alternative vectors. In addition to eluding HAd immunity, these vectors possess most of the attractive features of HAd vectors. Several replication-competent or replication-defective nonhuman adenoviral vectors have been developed and investigated for their potential as vaccine delivery vectors. Here, we review recent advances in the design and characterization of various nonhuman adenoviral vectors, and discuss their potential applications for human and animal vaccination.
has issue date	2006-02-01(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2005.08.101
bibo:pmid	16297508
has license	green-oa
sha1sum (hex)	a416350e5da8a35128cc4ab5d293c85d48f3e53d
schema:url	https://doi.org/10.1016/j.vaccine.2005.08.101
resource representing a document's title	Development of nonhuman adenoviruses as vaccine vectors
has PubMed Central identifier	PMC1462960
has PubMed identifier	16297508
schema:publication	Vaccine
resource representing a document's body	covid:a416350e5da8a35128cc4ab5d293c85d48f3e53d#body_text
is schema:about of	named entity 'VECTORS' named entity 'anticipated' named entity 'adenoviral' named entity 'immunity' named entity 'immunity' named entity 'vaccine' named entity 'potential' named entity 'vectors' named entity 'NONHUMAN' named entity 'USE OF' named entity 'ANIMAL' named entity 'ANTIGEN' named entity 'THEIR' named entity 'EFFICIENT' named entity 'USUALLY' named entity 'DEVELOPS' named entity 'EITHER' named entity 'VACCINE' named entity 'STRONG' named entity 'APPLICATIONS' named entity 'MOST OF' named entity 'COMPETENT' named entity 'REMOVES' named entity 'GREAT' named entity 'FEATURES' named entity 'LIMITED BY' named entity 'LIMITING' named entity 'CLINICAL' named entity 'TRANSGENE EXPRESSION' named entity 'VACCINE' named entity 'PROTECTIVE IMMUNITY' named entity 'DEVELOPMENT' named entity 'ADENOVIRUSES' named entity 'HUMAN' named entity 'PURPOSES' named entity 'ADENOVIRAL' named entity 'VECTORS' named entity 'RECENT' named entity 'VACCINATION' named entity 'SYSTEM' named entity 'ORDER' named entity 'PRECLINICAL AND CLINICAL STUDIES' named entity 'DELIVERY' named entity 'DURATION' named entity 'LIMITATION' named entity 'CHARACTERIZATION' named entity 'PARTICLES' named entity 'PROPOSED' named entity 'INVESTIGATED' named entity 'ALTERNATIVE' named entity 'DESIGN' named entity 'REPLICATION' named entity 'POSSESS' named entity 'DEFECTIVE' named entity 'SUBSEQUENT' named entity 'DUE TO' named entity 'INOCULATION' named entity 'ATTRACTIVE' named entity 'FOLLOWING' named entity 'ROBUST' named entity 'VARIOUS' named entity 'PREEXISTING' named entity 'ADDITION' named entity 'VECTOR' named entity 'EXPRESSION' named entity 'IMMUNITY' named entity 'POTENTIAL' named entity 'NONHUMAN' named entity 'DISCUSS' named entity 'CELLS' named entity 'THESE' named entity 'HERE' named entity 'DEMONSTRATED' named entity 'REVIEW' named entity 'USING' named entity 'FEASIBILITY' named entity 'ANTICIPATED' named entity 'HAVE' named entity 'RAPIDLY' covid:arg/a416350e5da8a35128cc4ab5d293c85d48f3e53d

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software