About: Type‐specific clinical characteristics of adenovirus‐associated influenza‐like illness at five US military medical centers, 2009

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About: Type‐specific clinical characteristics of adenovirus‐associated influenza‐like illness at five US military medical centers, 2009–2014 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Type‐specific clinical characteristics of adenovirus‐associated influenza‐like illness at five US military medical centers, 2009–2014
Creator	Lalani, Tahaniyat Mor, Deepika Chen, Wei-Ju Schofield, Christina Fairchok, Mary Rajnik, Michael Burgess, Timothy Arnold, John Danaher, Patrick Millar, Eugene Hansen, Erin Jackson, Henry Koren, Michael Ridor, Michelande
Source	Medline; PMC
abstract	BACKGROUND: Adenovirus is a recognized cause of influenza‐like illness (ILI). The proportion of ILI attributable to adenovirus is not known. Moreover, knowledge gaps remain with respect to the epidemiologic, virologic, and clinical characteristics of adenovirus‐associated ILI among otherwise healthy individuals. METHODS: An observational, longitudinal study of <65‐year‐old patients with febrile ILI at five medical centers was conducted from 2009 to 2014. Nasopharyngeal specimens obtained at enrollment were first tested by single‐reaction PCR for adenovirus, then further evaluated by a multiplex PCR assay for other respiratory viral pathogens. Symptoms over a 28‐day period were collected. RESULTS: We enrolled 1536 individuals, among whom 43 (2·8%) were positive for adenovirus. The median age of cases was 3·4 years (range: 4 months to 41 years). Three were hospitalized. Species and serotype information was available for 33 (76·7%) cases. Species C (n = 21) was the most common, followed by B3 (n = 9) and one each of E4a, D46, and A. Species C infections were more frequent in children (P < 0·01). Half of the cases were positive for at least one other respiratory viral pathogen. Symptoms were generally mild and most commonly included cough (90%), fatigue (79%), rhinorrhea (74%), loss of appetite (71%), and sore throat (64%). Children with non‐C adenovirus infection were more likely to report sore throat (P = 0·05) and hoarseness (P = 0·06) than those with species C infection. CONCLUSIONS: Adenovirus is frequently detected with other respiratory viruses. Persons with non‐C adenovirus infections reported more severe symptoms, suggesting there may be species‐specific differences in virulence and/or host response to infection.
has issue date	2016-05-13(xsd:dateTime)
bibo:doi	10.1111/irv.12392
bibo:pmid	27062998
has license	cc-by
sha1sum (hex)	a3ff62cdc7cd33bb6618950b28fe649bf95ef6de
schema:url	https://doi.org/10.1111/irv.12392
resource representing a document's title	Type‐specific clinical characteristics of adenovirus‐associated influenza‐like illness at five US military medical centers, 2009–2014
has PubMed Central identifier	PMC4947946
has PubMed identifier	27062998
schema:publication	Influenza Other Respir Viruses
resource representing a document's body	covid:a3ff62cdc7cd33bb6618950b28fe649bf95ef6de#body_text
is schema:about of	named entity 'Military Health System' named entity 'SAN ANTONIO' named entity 'HOST RESPONSE' named entity 'MAY BE' covid:arg/a3ff62cdc7cd33bb6618950b28fe649bf95ef6de named entity 'CONCLUSIONS' named entity 'RESPIRATORY VIRUSES' named entity 'RESPONSE TO' named entity 'MILITARY HEALTH' named entity 'FREQUENTLY' named entity 'SEVERE SYMPTOMS' named entity 'DETECTED' named entity 'ADENOVIRUS INFECTIONS' named entity 'INFECTION' named entity 'REPORTED' named entity 'VIRULENCE' named entity 'PERSONS' named entity 'ADENOVIRUS' named entity 'NON-' named entity 'HEALTH SYSTEM' named entity 'Persons' named entity 'severe' named entity 'adenovirus' named entity 'virulence' named entity 'infection' named entity 'Military Health' named entity 'serotypes' named entity 'infection' named entity 'sputum production' named entity 'study population' named entity 'adenovirus' named entity 'rhinorrhea' named entity 'risk factors' named entity 'adenovirus' named entity 'influenza-like Illness' named entity 'adenovirus' named entity 'adenovirus' named entity 'cough' named entity 'Infectious Disease' named entity 'PCR' named entity 'headache' named entity 'adenovirus' named entity 'clinical characteristics' named entity 'adenovirus vaccine' named entity 'rhinorrhea' named entity 'adenovirus' named entity 'symptom' named entity 'rhinovirus' named entity 'cough' named entity 'chest pain' named entity 'United States' named entity 'adenovirus' named entity 'endemic' named entity 'respiratory disease' named entity 'viruses' named entity 'adenovirus' named entity 'clinical microbiology' named entity 'coronavirus' named entity 'metapneumovirus' named entity 'adenovirus' named entity 'sore throat' named entity 'multiplex PCR' named entity 'runny nose' named entity 'pathogens' named entity 'SAS software' named entity 'statistical significance' named entity 'informed consent' named entity 'acute respiratory infection'

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