About: Enhanced transduction of CAR-negative cells by protein IX-gene deleted adenovirus 5 vectors

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About: Enhanced transduction of CAR-negative cells by protein IX-gene deleted adenovirus 5 vectors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Enhanced transduction of CAR-negative cells by protein IX-gene deleted adenovirus 5 vectors
Creator	Bárcena, Montserrat Koppers-Lalic, Danijela Kraaij, Robert Yamamoto, Masato Dautzenberg, Iris Hoeben, Rob Kwappenberg, Kitty De Ridder, Corrina De Vrij, Jeroen Schilham, Marco Stassen, Oscar Uil, Taco Van Den Hengel, Sanne
Source	Elsevier; Medline; PMC
abstract	Abstract In human adenoviruses (HAdV), 240 copies of the 14.3-kDa minor capsid protein IX stabilize the capsid. Three N-terminal domains of protein IX form triskelions between hexon capsomers. The C-terminal domains of four protein IX monomers associate near the facet periphery. The precise biological role of protein IX remains enigmatic. Here we show that deletion of the protein IX gene from a HAdV-5 vector enhanced the reporter gene delivery 5 to 25-fold, specifically to Coxsackie and Adenovirus Receptor (CAR)-negative cell lines. Deletion of the protein IX gene also resulted in enhanced activation of peripheral blood mononuclear cells. The mechanism for the enhanced transduction is obscure. No differences in fiber loading, integrin-dependency of transduction, or factor-X binding could be established between protein IX-containing and protein IX-deficient particles. Our data suggest that protein IX can affect the cell tropism of HAdV-5, and may function to dampen the innate immune responses against HAdV particles.
has issue date	2011-02-05(xsd:dateTime)
bibo:doi	10.1016/j.virol.2010.10.040
bibo:pmid	21130482
has license	els-covid
sha1sum (hex)	a3a1e33a44baf0d1636040ed2b7ef4dce2d14364
schema:url	https://doi.org/10.1016/j.virol.2010.10.040
resource representing a document's title	Enhanced transduction of CAR-negative cells by protein IX-gene deleted adenovirus 5 vectors
has PubMed Central identifier	PMC7111976
has PubMed identifier	21130482
schema:publication	Virology
resource representing a document's body	covid:a3a1e33a44baf0d1636040ed2b7ef4dce2d14364#body_text
is schema:about of	named entity 'ADENOVIRUS 5' named entity 'VECTORS' named entity 'C-terminal' named entity 'stabilize' named entity 'deleted' named entity 'ENHANCED' named entity 'PROTEIN ' named entity 'CAPSID' named entity 'MINOR' named entity 'TRANSDUCTION' named entity 'REPORTER GENE' named entity 'THE CELL' named entity 'PROTEIN ' named entity 'FACTOR' named entity 'COULD BE' named entity 'CONTAINING' named entity 'PRECISE' named entity 'N-TERMINAL ' covid:arg/a3a1e33a44baf0d1636040ed2b7ef4dce2d14364 named entity 'DELETED' named entity 'KDA' named entity 'PARTICLES' named entity 'BINDING' named entity 'DEFICIENT' named entity 'OBSCURE' named entity 'IMMUNE RESPONSES' named entity 'FIBER' named entity 'ENHANCED' named entity 'FORM' named entity 'HUMAN' named entity 'AFFECT' named entity 'FUNCTION' named entity 'VECTOR' named entity 'TRANSDUCTION' named entity 'FOLD' named entity 'GENE DELIVERY' named entity 'CELL LINES' named entity 'NEAR' named entity 'OUR' named entity 'HERE' named entity 'ASSOCIATE' named entity 'NEGATIVE' named entity 'COPIES' named entity 'FACET' named entity 'CAPSID PROTEIN' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'STABILIZE' named entity 'LOADING' named entity 'CELLS' named entity 'GENE' named entity 'CAR' named entity 'ESTABLISHED' named entity 'ADENOVIRUSES' named entity 'HEXON' named entity 'TROPISM' named entity 'C-TERMINAL' named entity 'ADENOVIRUS RECEPTOR' named entity 'DELETION' named entity '240' named entity 'GENE' named entity 'BIOLOGICAL ROLE' named entity 'ACTIVATION' named entity 'PERIPHERY' named entity 'SUGGEST' named entity 'MONOMERS' named entity 'NEGATIVE' named entity 'MECHANISM' named entity 'DATA' named entity 'Receptor'

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