About: SARS coronavirus induces apoptosis in Vero E6 Cells

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS coronavirus induces apoptosis in Vero E6 Cells
Creator	Yan, Huimin Xiao, Gengfu Gao, George Zheng, Congyi Hu, Yuanyang Yuan, Fang Zhang, Jiamin Cole, David
Source	Medline; PMC
abstract	Severe acute respiratory syndrome (SARS) is an emerging infectious disease. Its etiological agent has been convincingly identified as a new member of family Coronaviridae (SARS‐CoV). It causes serious damage to the respiratory system yet the mechanism is not clear. Infection‐induced apoptosis or necrosis is suspected but no direct evidence for this yet exists. To date, Vero E6 cells are the only cell line that could be used to replicate the virus with obvious CPE (cytopathic effect) in vitro. It is known for some viruses (including members of family Coronaviridae) that CPE can be caused either by virus‐induced apoptosis (active death) or cell necrosis (passive death). In this study, we examined the apoptosis in the SARS‐CoV infected Vero E6 cells. Indeed, the results do show that the CPE was induced by apoptosis rather than necrosis, shown by typical DNA fragmentation, through the existence of apoptotic bodies and swollen mitochondria. This observation has some implications for the SARS‐CoV pathogenicity: SARS‐CoV does induce apoptosis in cell cultures and might have the same effect in vivo, responsible for the severe damage of the respiratory system. J. Med. Virol. 73:323–331, 2004. © 2004 Wiley‐Liss, Inc.
has issue date	2004-05-24(xsd:dateTime)
bibo:doi	10.1002/jmv.20094
bibo:pmid	15170624
has license	no-cc
sha1sum (hex)	a358346359fd768ea1b35da55a8bc312b8717676
schema:url	https://doi.org/10.1002/jmv.20094
resource representing a document's title	SARS coronavirus induces apoptosis in Vero E6 Cells
has PubMed Central identifier	PMC7166321
has PubMed identifier	15170624
schema:publication	J Med Virol
resource representing a document's body	covid:a358346359fd768ea1b35da55a8bc312b8717676#body_text
is schema:about of	named entity 'Severe acute respiratory syndrome (SARS)' named entity 'pathogenicity' named entity 'caused' named entity 'active' named entity 'clear' named entity 'SARS-CoV' named entity 'Apoptosis' named entity 'SEVERE' named entity 'EXAMINED' named entity 'SARS-COV' named entity 'HAVE' named entity 'KNOWN' named entity 'AGENT' named entity 'VIRUSES' named entity 'EVIDENCE FOR' named entity 'CELL' named entity 'COULD BE' named entity 'EMERGING INFECTIOUS DISEASE' named entity 'ITS' named entity 'DATE' named entity 'RESULTS' named entity 'cells' named entity 'cell' named entity 'necrosis' named entity 'This' named entity 'Vero' named entity 'necrosis' named entity 'Coronaviridae' named entity 'SARS-CoV' named entity 'apoptotic bodies' named entity 'SARS-CoV' named entity 'necrosis' named entity 'apoptosis' named entity 'emerging infectious disease' named entity 'SARS' named entity 'virus' named entity 'Coronaviridae' named entity 'syncytia' named entity 'Hubei' named entity 'MOI' named entity 'SARS-CoV' named entity 'MOI' named entity 'necrosis' named entity 'apoptosis' named entity 'necrosis' named entity 'epithelial cell' named entity 'coronaviruses' named entity 'Koch's postulates' named entity 'SARS-CoV' named entity 'FCS' named entity 'FITC' named entity 'RT-PCR' named entity 'apoptotic cells' named entity 'Coronaviridae' named entity 'Sigma-Aldrich' named entity 'lung' named entity 'infection' named entity 'transmission electron microscope' named entity 'nuclear membrane' named entity 'apoptotic' named entity 'apoptotic bodies' named entity 'SARS' named entity 'lytic' named entity 'apoptosis' named entity 'Apoptosis' named entity 'feline infectious peritonitis virus' named entity 'SARS' named entity 'lung' named entity 'SARS-CoV' named entity 'viral infection' named entity 'SARS-CoV' named entity 'cell line' named entity 'Vero E6' named entity 'coronavirus'

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