About: A potent human neutralizing antibody Fc-dependently reduces established HBV infections

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A potent human neutralizing antibody Fc-dependently reduces established HBV infections
Creator	Li, Dan Li, Wenhui Du, Kaixin He, Wenhui Li, Huiyu Liu, Juan Liu, Ximing Mao, Fengfeng Pan, Lijing Qi, Yonghe Sui, Jianhua Sun, Yinyan Ye, Keqiong Zheng, Sanduo
Source	PMC
abstract	Hepatitis B virus (HBV) infection is a major global health problem. Currently-available therapies are ineffective in curing chronic HBV infection. HBV and its satellite hepatitis D virus (HDV) infect hepatocytes via binding of the preS1 domain of its large envelope protein to sodium taurocholate cotransporting polypeptide (NTCP). Here, we developed novel human monoclonal antibodies that block the engagement of preS1 with NTCP and neutralize HBV and HDV with high potency. One antibody, 2H5-A14, functions at picomolar level and exhibited neutralization-activity-mediated prophylactic effects. It also acts therapeutically by eliciting antibody-Fc-dependent immunological effector functions that impose durable suppression of viral infection in HBV-infected mice, resulting in reductions in the levels of the small envelope antigen and viral DNA, with no emergence of escape mutants. Our results illustrate a novel antibody-Fc-dependent approach for HBV treatment and suggest 2H5-A14 as a novel clinical candidate for HBV prevention and treatment of chronic HBV infection.
has issue date	2017-09-26(xsd:dateTime)
bibo:doi	10.7554/elife.26738
bibo:pmid	28949917
has license	cc-by
sha1sum (hex)	a348cf052e162d6156b8179a82058aff4a0af407
schema:url	https://doi.org/10.7554/elife.26738
resource representing a document's title	A potent human neutralizing antibody Fc-dependently reduces established HBV infections
has PubMed Central identifier	PMC5614562
has PubMed identifier	28949917
resource representing a document's body	covid:a348cf052e162d6156b8179a82058aff4a0af407#body_text
is schema:about of	named entity 'NEUTRALIZING ANTIBODY' named entity 'developed' named entity 'DNA' named entity 'viral infection' named entity 'levels' named entity 'binding' named entity 'prophylactic' named entity 'FUNCTIONS' named entity 'NTCP' named entity 'HUMAN' named entity 'LEVEL' named entity 'TREATMENT' named entity 'DOMAIN' named entity 'PROTEIN ' named entity 'PROPHYLACTIC' named entity 'PICOMOLAR' named entity 'ESCAPE' named entity 'HUMAN' named entity 'APPROACH' named entity 'HEPATITIS B VIRUS' named entity 'BLOCK' named entity 'HERE' named entity 'MUTANTS' named entity 'OUR' named entity 'VIRAL DNA' named entity 'ITS' named entity 'HEALTH PROBLEM' named entity 'SATELLITE' named entity 'ENVELOPE PROTEIN' named entity 'ENVELOPE' named entity 'NOVEL' named entity 'CHRONIC' named entity 'SUPPRESSION' named entity 'A MAJOR' named entity 'MONOCLONAL ANTIBODIES' named entity 'MICE' named entity 'INFECTIONS' named entity 'ANTIGEN' named entity 'DEPENDENT' named entity 'VIRAL INFECTION' named entity 'RESULTING IN' named entity 'BINDING' named entity 'HEPATOCYTES' named entity 'EMERGENCE' named entity 'HBV' named entity 'A14' named entity 'IMMUNOLOGICAL' named entity 'ENGAGEMENT' named entity 'IS A' named entity 'INEFFECTIVE' named entity 'CURRENTLY' named entity 'HBV' named entity 'GLOBAL HEALTH' named entity 'CLINICAL' named entity 'ESTABLISHED' named entity 'HEPATITIS D VIRUS' named entity 'HBV INFECTION' named entity 'EFFECTS' named entity 'RESULTS' named entity 'INFECTION' named entity 'ANTIBODY' named entity 'POLYPEPTIDE' named entity 'POTENCY' named entity 'CANDIDATE' named entity 'EFFECTOR' named entity 'IMPOSE' named entity 'INFECT' named entity 'PREVENTION' named entity 'LEVELS'

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