About: Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?
Creator	Sureda, A Alizadeh, J Berindan Neagoe, I Cismaru, C Clementi, E Ghavami, S Jeandet, P Journal Of Pharmacology, European Los, M Nabavi, S
source	Elsevier; Medline; PMC
abstract	In December 2019, many pneumonia cases with unidentified sources appeared in Wuhan, Hubei, China, with clinical symptoms like viral pneumonia. Deep sequencing analysis of samples from lower respiratory tract revealed a novel coronavirus, called 2019 novel coronavirus (2019-nCoV). Currently there is a rapid global spread. World Health Organization declare the disease a pandemic condition. The pathologic source of this disease was a new RNA virus from Coronaviridae family, which was named COVID-19. SARS-CoV-2 entry starts with the binding of the spike glycoprotein expressed on the viral envelope to ACE2 on the alveolar surface followed by clathrin-dependent endocytosis of the SARS-CoV-2 and ACE2 complex. SARS-CoV-2 enters the cells through endocytosis process, which is possibly facilitated, via a pH dependent endosomal cysteine protease cathepsins. Once inside the cells, SARS-CoV-2 exploits the endogenous transcriptional machinery of alveolar cells to replicate and spread through the entire lung. Endosomal acidic pH for SARS-CoV-2 processing and internalization is critical. After entering the cells, it possibly activates or hijack many intracellular pathways in favor of its replication. In the current opinion article, we will explain the possible involvement of unfolded protein response as a cellular stress response to the SARS-CoV-2 infection.
has issue date	2020-06-17(xsd:dateTime)
bibo:doi	10.1016/j.ejphar.2020.173288
bibo:pmid	32561291
has license	no-cc
sha1sum (hex)	a306e80fbdd0733f720d9cf0eeeeb70abc0e4f7d
schema:url	https://doi.org/10.1016/j.ejphar.2020.173288
resource representing a document's title	Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?
has PubMed Central identifier	PMC7297682
has PubMed identifier	32561291
schema:publication	Eur J Pharmacol
resource representing a document's body	covid:a306e80fbdd0733f720d9cf0eeeeb70abc0e4f7d#body_text
is schema:about of	named entity 'therapeutic' named entity 'PERK' named entity 'UPR' named entity 'transmembrane' named entity 'covid-19' named entity 'infection' named entity 'ATF6' named entity 'endoplasmic reticulum' named entity 'kinase' named entity 'kinase' named entity 'enzyme' named entity 'inositol' named entity 'transcriptional factor' named entity 'IRE1α' named entity 'protein' named entity 'covid-19' named entity 'Endoplasmic reticulum' named entity 'therapeutic target' named entity 'infection' named entity 'target' named entity 'potential' named entity 'ENDOPLASMIC RETICULUM' named entity 'THERAPEUTIC TARGET' named entity 'COVID-19 INFECTION' named entity 'Endoplasmic reticulum' named entity 'management' named entity 'POTENTIAL' named entity 'MANAGEMENT'
is part of of	covid:a306e80fbdd0733f720d9cf0eeeeb70abc0e4f7d#body_text In December 2019, many pneumonia cases with unidentified sources appeared in Wuhan, Hubei, China, with clinical symptoms like viral pneumonia. Deep sequencing analysis of samples from lower respiratory tract revealed a novel coronavirus, called 2019 novel coronavirus (2019-nCoV). Currently there is a rapid global spread. World Health Organization declare the disease a pandemic condition. The pathologic source of this disease was a new RNA virus from Coronaviridae family, which was named COVID-19. SARS-CoV-2 entry starts with the binding of the spike glycoprotein expressed on the viral envelope to ACE2 on the alveolar surface followed by clathrin-dependent endocytosis of the SARS-CoV-2 and ACE2 complex. SARS-CoV-2 enters the cells through endocytosis process, which is possibly facilitated, via a pH dependent endosomal cysteine protease cathepsins. Once inside the cells, SARS-CoV-2 exploits the endogenous transcriptional machinery of alveolar cells to replicate and spread through the entire lung. Endosomal acidic pH for SARS-CoV-2 processing and internalization is critical. After entering the cells, it possibly activates or hijack many intracellular pathways in favor of its replication. In the current opinion article, we will explain the possible involvement of unfolded protein response as a cellular stress response to the SARS-CoV-2 infection. Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?

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