About: Diagnostic and Prognostic Values of Admission Procalcitonin Levels in Community–Acquired Pneumonia in an Intensive Care Unit

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About: Diagnostic and Prognostic Values of Admission Procalcitonin Levels in Community–Acquired Pneumonia in an Intensive Care Unit Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Diagnostic and Prognostic Values of Admission Procalcitonin Levels in Community–Acquired Pneumonia in an Intensive Care Unit
Creator	Georges, H Guery, B Leroy, O D'escrivan, T Boussekey, N Devos, P
Source	PMC
abstract	BACKGROUND: Measurement of procalcitonin (PCT) has been studied for several years in infectious diseases. Some studies have focused on community–acquired pneumonia (CAP) but only one was conducted in critically ill patients hospitalized in an intensive care unit (ICU). PATIENTS AND METHODS: To determine the diagnostic and prognostic role of PCT in patients admitted in an intensive care unit for severe CAP, 110 patients hospitalized in our unit were prospectively studied. Within 48 hours following ICU admission, PCT serum level was measured with a quantitative method above a threshold value of 0.5 ng/ml. RESULTS: Initially focusing on the diagnostic value of PCT, 20% of the patients had a serum PCT level < 0.5 ng/ml, 30% between 0.5 ng/ml and 2 ng/ml, and 50% ≥ 2 ng/ml. Serum PCT level was higher in microbiologically documented CAP (median = 4.9 ng/ml vs 1.5 ng/ml if no bacteria were found; p = 0.001), but was not predictive of any specific bacterial agent. Concerning the prognostic value, the serum PCT level was higher for bacteremic patients and/or septic shock patients (4.9 ng/ml vs 1.5 ng/ml; p = 0.0003). Moreover, PCT levels were increased in patients who developed, during their ICU stay, infection–related complications (septic shock, multiorgan dysfunction, acute respiratory distress syndrome and disseminated intravascular coagulation). Finally, the initial PCT level was significantly higher in patients who died during the ICU stay (5.6 ng/ml vs 1.5 ng/ml; p < 0.0001). Such a relationship was not found with C–reactive protein (CRP). CONCLUSION: In ICU patients admitted for severe CAP, initial PCT values could be an interesting predictor for complications and mortality.
has issue date	2005-01-01(xsd:dateTime)
bibo:doi	10.1007/s15010-005-4096-2
bibo:pmid	16091896
has license	no-cc
sha1sum (hex)	a304d536ecb74040a8271e7a27211ebc169dbce6
schema:url	https://doi.org/10.1007/s15010-005-4096-2
resource representing a document's title	Diagnostic and Prognostic Values of Admission Procalcitonin Levels in Community–Acquired Pneumonia in an Intensive Care Unit
has PubMed Central identifier	PMC7102380
has PubMed identifier	16091896
schema:publication	Infection
resource representing a document's body	covid:a304d536ecb74040a8271e7a27211ebc169dbce6#body_text
is schema:about of	named entity 'Some' named entity 'intensive care unit (ICU)' named entity 'community-acquired pneumonia' named entity 'Prognostic' named entity 'PROCALCITONIN' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'PCT' named entity 'upper quartile' named entity 'Streptococcus pneumoniae' named entity 'S. pneumoniae' named entity 'CAP' named entity 'CRP' named entity 'systemic corticosteroids' named entity 'prognostic factor' named entity 'DIC' named entity 'E. coli' named entity '3.5' named entity 'organism' named entity 'infection' named entity 'infection' named entity 'infectious diseases' named entity 'CAP' named entity 'CAP' named entity 'lower respiratory tract' named entity 'procalcitonin' named entity '5.4' named entity 'bacteremia' named entity 'sepsis' named entity 'leukocyte count' named entity 'organism' named entity 'chest pain' named entity 'PCT' named entity 'S. aureus' named entity 'blood samples' named entity 'serum' named entity 'etiology' named entity 'intracellular bacteria' named entity 'S. pneumoniae' named entity 'Staphylococcus aureus' named entity 'lower respiratory tract infections' named entity 'standard deviation' named entity 'fluid replacement' named entity 'S. aureus' named entity 'systolic blood pressure' named entity 'infection' named entity 'C-reactive protein' named entity 'assay' named entity 'SAPS II' named entity 'bronchoalveolar lavage' named entity 'CAP' named entity 'CAP' named entity 'Prognostic' named entity 'CAP' named entity 'clinical studies' named entity 'CAP' named entity 'CRP' named entity 'CAP' named entity '5.6' named entity 'blood cultures' named entity 'Sensitivity and specificity' named entity 'evolution' named entity 'ARDS' named entity 'severe sepsis' named entity 'analysis of variance' named entity 'bacteremia' named entity 'pathogens' named entity 'pulmonary infiltrate' named entity 'organism' named entity 'acute respiratory distress syndrome' named entity 'septic shock' named entity 'severe sepsis' named entity 'lung carcinoma' named entity 'catheter' named entity 'cutoff values' named entity 'systolic blood pressure' named entity 'pulmonary embolus'

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