About: Respiratory viral infection in lower airways of asymptomatic children

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Respiratory viral infection in lower airways of asymptomatic children
Creator	Coyle, P Doherty, G Christie, S Thavagnanam, S
Source	Medline; PMC
abstract	Aim: The aim of this study was to determine if asthmatic children have viruses more commonly detected in lower airways during asymptomatic periods than normal children. Methods: Fifty‐five asymptomatic children attending elective surgical procedures (14 with stable asthma, 41 normal controls) underwent non‐bronchoscopic bronchoalveolar lavage. Differential cell count and PCR for 13 common viruses were performed. Results: Nineteen (35%) children were positive for at least one virus, with adenovirus being most common. No differences in the proportion of viruses detected were seen between asthmatic and normal ‘control’ children. Viruses other than adenovirus were associated with higher neutrophil counts, suggesting that they caused an inflammatory response in both asthmatics and controls (median BAL neutrophil count, 6.9% for virus detected vs. 1.5% for virus not detected, p = 0.03). Conclusions: Over one‐third of asymptomatic children have a detectable virus (most commonly adenovirus) in the lower airway; however, this was not more common in asthmatics. Viruses other than adenovirus were associated with elevated neutrophils suggesting that viral infection can be present during relatively asymptomatic periods in asthmatic children.
has issue date	2009-12-09(xsd:dateTime)
bibo:doi	10.1111/j.1651-2227.2009.01627.x
bibo:pmid	20003105
has license	no-cc
sha1sum (hex)	a2b7d3d9019fee8844170442648eceaca3ddc047
schema:url	https://doi.org/10.1111/j.1651-2227.2009.01627.x
resource representing a document's title	Respiratory viral infection in lower airways of asymptomatic children
has PubMed Central identifier	PMC7159555
has PubMed identifier	20003105
schema:publication	Acta Paediatr
resource representing a document's body	covid:a2b7d3d9019fee8844170442648eceaca3ddc047#body_text
is schema:about of	named entity 'Nineteen' named entity 'count' named entity 'viral infection' named entity 'CHILDREN' named entity 'ASTHMA' named entity 'BRONCHOSCOPIC BRONCHOALVEOLAR LAVAGE' named entity 'VIRUS NOT DETECTED' named entity 'ASTHMATIC' named entity 'PERFORMED' named entity '1.5' named entity 'STUDY' named entity 'ASSOCIATED WITH' named entity 'VIRUS' named entity 'CELL COUNT' named entity 'viruses' named entity 'viruses' named entity 'inflammatory response' named entity 'virus' named entity 'Results' named entity 'counts' named entity 'bronchoalveolar lavage' named entity 'viruses' named entity 'controls' named entity 'commonly' named entity 'cell count' named entity 'viruses' named entity 'asymptomatic' named entity 'viruses' named entity 'asthma' named entity 'viral infection' named entity 'asymptomatic' named entity 'viruses' named entity 'bronchoscopic' named entity 'rhinovirus' named entity 'asthma' named entity 'Positive and negative controls' named entity 'adenoviral' named entity 'adenovirus' named entity 'standard deviation' named entity 'inflammatory response' named entity 'viruses' named entity 'asthmatics' named entity 'RT-PCR' named entity 'adenovirus' named entity 'virus' named entity 'asymptomatic' named entity 'virus' named entity 'viruses' named entity 'asthmatic' named entity 'EBV' named entity 'nasal secretions' named entity 'asthma' named entity 'HSV' named entity 'symptoms of a cold' named entity 'herpes simplex virus' named entity 'asthma' named entity 'viruses' named entity 'neutrophil' named entity 'asthma exacerbation' named entity 'respiratory tract infection' named entity 'wheeze' named entity '3.5' named entity 'EBV' named entity 'asthmatic' named entity 'adenovirus' named entity 'inflammation' named entity 'asthma' named entity 'anti-inflammatory' named entity 'adenovirus' named entity 'atopy' named entity 'viral proteins' named entity 'HSV' named entity 'asthmatic' named entity 'primers' named entity 'infection' named entity 'lysis buffer' named entity 'Epstein-Barr virus' named entity 'RT-PCR'

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