About: Lysosomes as a therapeutic target

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lysosomes as a therapeutic target
Creator	Muller, Sylviane Wang, Fengjuan Reddy Bonam, Srinivasa
Source	Medline; PMC
abstract	Lysosomes are membrane-bound organelles with roles in processes involved in degrading and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes encoding lysosomal proteins cause lysosomal storage disorders, in which enzyme replacement therapy has proved successful. Growing evidence also implicates roles for lysosomal dysfunction in more common diseases including inflammatory and autoimmune disorders, neurodegenerative diseases, cancer and metabolic disorders. With a focus on lysosomal dysfunction in autoimmune disorders and neurodegenerative diseases — including lupus, rheumatoid arthritis, multiple sclerosis, Alzheimer disease and Parkinson disease — this Review critically analyses progress and opportunities for therapeutically targeting lysosomal proteins and processes, particularly with small molecules and peptide drugs.
has issue date	2019-09-02(xsd:dateTime)
bibo:doi	10.1038/s41573-019-0036-1
bibo:pmid	31477883
has license	no-cc
sha1sum (hex)	a291686d0744c0e784513f9cb8aec79f0c93d74e
schema:url	https://doi.org/10.1038/s41573-019-0036-1
resource representing a document's title	Lysosomes as a therapeutic target
has PubMed Central identifier	PMC7097195
has PubMed identifier	31477883
schema:publication	Nat Rev Drug Discov
resource representing a document's body	covid:a291686d0744c0e784513f9cb8aec79f0c93d74e#body_text
is schema:about of	named entity 'autoimmune disorders' named entity 'diseases' named entity 'common' named entity 'Lysosomes' named entity 'dysfunction' named entity 'multiple sclerosis' named entity 'targeting' named entity 'therapeutically' named entity 'processes' named entity 'recycling' named entity 'lysosomal proteins' named entity 'therapeutic' named entity 'small molecules' named entity 'lysosomal' named entity 'lupus' named entity 'Lysosomes' named entity 'autophagosome' named entity 'exogenous' named entity 'TFEB' named entity 'reactive oxygen species' named entity 'autoantibodies' named entity 'Endocytosis' named entity 'protein' named entity 'lysosomes' named entity 'transcription' named entity 'protein' named entity 'cell growth' named entity 'lysosomes' named entity 'protein' named entity 'ALS' named entity 'apoptosis' named entity 'exon' named entity 'autophagy' named entity 'autophagy' named entity 'MLIV' named entity 'cellular signalling' named entity 'invagination' named entity 'epithelial cells' named entity 'cholesterol' named entity 'cellular material' named entity 'proton' named entity 'HSPA8' named entity 'cathepsins' named entity 'Biodistribution' named entity 'RER' named entity 'biogenesis' named entity 'rat model' named entity 'unde' named entity 'lysosome' named entity 'haplotypes' named entity 'presenilin' named entity 'Chediak-Higashi disease' named entity 'chaperone' named entity 'CMA' named entity 'endocytosis' named entity 'neuropsychiatric lupus' named entity 'TRPML1' named entity 'phase III trial' named entity 'secretion' named entity 'lysosomal' named entity 'SNCA' named entity 'lysosomal disease' named entity 'CMA' named entity 'lSD' named entity 'galactosylceramide' named entity 'TFEB' named entity 'substrate' named entity 'ERT' named entity 'lysosomes' named entity 'TLRs' named entity 'autophagy' named entity 'lysosomes' named entity 'TFEB' named entity 'phenotype' named entity 'protein' named entity 'lysosomes' named entity 'Small molecules' named entity 'antigen presenting cells' named entity 'lymphocytes'

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