About: Human, Nonhuman Primate, and Bat Cells Are Broadly Susceptible to Tibrovirus Particle Cell Entry

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About: Human, Nonhuman Primate, and Bat Cells Are Broadly Susceptible to Tibrovirus Particle Cell Entry Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human, Nonhuman Primate, and Bat Cells Are Broadly Susceptible to Tibrovirus Particle Cell Entry
Creator	Palacios, Gustavo Wiley, Michael Caì, Yíngyún Chandran, Kartik Lauck, Michael Wada, Jiro Yú, Shuǐqìng Postnikova, Elena Matsuno, Keita Chiu, Charles Tesh, Robert Finch, Courtney Cl, Finch Cy, Chiu Dh, Connor En, Postnikova Jangra, Rohit Jh, Kuhn Kuhn, Jens Lauck, M Mr, Wiley O'connor, David Radoshitzky, Sheli Rb, Tesh Rk, Jangra Roberto Perez, Daniel Spj, Whelan Sr, O', Radoshitzky Whelan, Sean Whittaker, Gary
Source	PMC
abstract	In 2012, the genome of a novel rhabdovirus, Bas-Congo virus (BASV), was discovered in the acute-phase serum of a Congolese patient with presumed viral hemorrhagic fever. In the absence of a replicating virus isolate, fulfilling Koch’s postulates to determine whether BASV is indeed a human virus and/or pathogen has been impossible. However, experiments with vesiculoviral particles pseudotyped with Bas-Congo glycoprotein suggested that BASV particles can enter cells from multiple animals, including humans. In 2015, genomes of two related viruses, Ekpoma virus 1 (EKV-1) and Ekpoma virus 2 (EKV-2), were detected in human sera in Nigeria. Isolates could not be obtained. Phylogenetic analyses led to the classification of BASV, EKV-1, and EKV-2 in the same genus, Tibrovirus, together with five biting midge-borne rhabdoviruses [i.e., Beatrice Hill virus (BHV), Bivens Arm virus (BAV), Coastal Plains virus (CPV), Sweetwater Branch virus (SWBV), and Tibrogargan virus (TIBV)] not known to infect humans. Using individual recombinant vesiculoviruses expressing the glycoproteins of all eight known tibroviruses and more than 75 cell lines representing different animal species, we demonstrate that the glycoproteins of all tibroviruses can mediate vesiculovirus particle entry into human, bat, nonhuman primate, cotton rat, boa constrictor, and Asian tiger mosquito cells. Using four of five isolated authentic tibroviruses (i.e., BAV, CPV, SWBV, and TIBV), our experiments indicate that many cell types may be partially resistant to tibrovirus replication after virion cell entry. Consequently, experimental data solely obtained from experiments using tibrovirus surrogate systems (e.g., vesiculoviral pseudotypes, recombinant vesiculoviruses) cannot be used to predict whether BASV, or any other tibrovirus, infects humans.
has issue date	2019-04-26(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.00856
bibo:pmid	31105663
has license	cc-by
sha1sum (hex)	a27adabfa89d32df634f7e7a9a6056b36ded5031
schema:url	https://doi.org/10.3389/fmicb.2019.00856
resource representing a document's title	Human, Nonhuman Primate, and Bat Cells Are Broadly Susceptible to Tibrovirus Particle Cell Entry
has PubMed Central identifier	PMC6499107
has PubMed identifier	31105663
schema:publication	Front Microbiol
resource representing a document's body	covid:a27adabfa89d32df634f7e7a9a6056b36ded5031#body_text
is schema:about of	named entity 'Cell' named entity 'BAT' named entity 'NONHUMAN PRIMATE' named entity 'CITATION' named entity 'SUSCEPTIBLE' named entity 'TIBROVIRUS' named entity 'ENTRY' named entity 'PARTICLE' named entity 'CELLS' named entity 'HUMAN' named entity 'CELL' named entity 'Nonhuman Primate' named entity 'tibrovirus' named entity 'tibrovirus' named entity 'kidney' named entity 'Asian tiger mosquito' named entity 'porcine' named entity 'Sigma-Aldrich' named entity 'Primary antibodies' named entity 'negative-sense single-stranded RNA viruses' named entity 'bat' named entity 'PerkinElmer' named entity 'tibrovirus' named entity 'glycoprotein' named entity 'glycoprotein' named entity 'Rockville, MD' named entity 'nucleoprotein' named entity 'ATCC' named entity 'Aedes albopictus' named entity 'tibrovirus' named entity 'cell lines' named entity '3T3' named entity 'Asian tiger mosquito' named entity 'cell lines' named entity 'antibodies' named entity 'renal cancer' named entity 'ThermoFisher Scientific' named entity 'Frederick, MD' named entity 'glycoprotein' named entity 'cloned' named entity 'boa constrictor' named entity 'cell entry' named entity 'cell lines' named entity 'United States' named entity 'glycoprotein' named entity 'tibrovirus' named entity 'cell line' named entity 'Arboviruses' named entity 'cell lines' named entity 'inoculation' named entity 'tropism' named entity 'Hoechst 33342'

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