About: Treatments administered to the first 9,152 reported cases of COVID19: a systematic review

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Treatments administered to the first 9,152 reported cases of COVID19: a systematic review
Creator	Bs, M David, C Kim, C Angelides, Philip Beschloss, Alexander Fajgenbaum, David Frankl, Sarah Go, Beatrice Hernandez-Miyares, Laura Jiang, Joanna Jiang, J Kakkis, Joseph Khor, Johnson Kim, Casey Mackay, Duncan Mayer, Michael Napier, Erin Nimgaonkar, Vivek Pai, Ruth-Anne Pierson, Sheila Powers, Victoria Rasheed, Rozena Repasky, Mileva Tamakloe, Mark-Avery Taylor, Anne Amurthur, Ashwin Ba, Frankl Bambury, Stephen Bs, Ba Bse, A Fajgenbaum, Fisher, Megan Germi, J Germi, James Goodyear, Nick Gorzewski, Alek Gunderson, Karen Keyser, Cornelia Martins, Bruna Mccarthy, Madison Rodriguez-Lopez, Eric Sc, Angelides Wing Bs, A Wing, Anna
Source	MedRxiv
abstract	Background The emergence of SARS-CoV-2/2019 novel coronavirus (COVID19) has created a global pandemic with no approved treatments or vaccines. Repurposing existing drugs and rapidly launching clinical trials present the greatest near-term opportunities for mitigating COVID19s impact. Many treatments have already been administered to COVID19 patients but have not been systematically evaluated. We performed a systematic literature review to identify and assess all treatments reported to be administered to COVID19 patients. Methods We searched PubMed, BioRxiv, MedRxiv, and ChinaXiv for articles reporting treatments for COVID19 patients published between Dec 1, 2019 and Mar 27, 2020. All studies reporting treatments were included. Data for each paper were manually extracted by two independent extractors. Outcomes included the duration from drug administration to clinically-meaningful response (complete symptom resolution or hospital discharge). Data were analysed descriptively. Results We identified 2,706 articles from single patient case reports to single-centre interventional studies. Of these, 155 studies met inclusion criteria, comprising 9,152 patients from 14 different countries. The cohort was 45.4% female and 98.3% hospitalised, and mean (SD) age was 44.4 years (SD 21.0). The most frequently administered drug classes were antivirals, antibiotics, and corticosteroids, and of the 115 reported drugs, the most frequently administered was combination lopinavir/ritonavir, which was associated with a response time of 11.7 (1.09) days. Discussion A large number of treatments have been administered to the first 9,152 reported cases of COVID19. Further work is needed to prioritise drugs for investigation in well-controlled clinical trials and treatment protocols. Funding None.
has issue date	2020-05-11(xsd:dateTime)
bibo:doi	10.1101/2020.05.07.20073981
has license	medrxiv
sha1sum (hex)	a26855c5f22fc231535a1b9a555ad2843947cbf6
schema:url	https://doi.org/10.1101/2020.05.07.20073981
resource representing a document's title	Treatments administered to the first 9,152 reported cases of COVID19: a systematic review
resource representing a document's body	covid:a26855c5f22fc231535a1b9a555ad2843947cbf6#body_text
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