About: ACE1 polymorphism and progression of SARS

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	ACE1 polymorphism and progression of SARS
Creator	Hijikata, Minako Keicho, Naoto Matsushita, Ikumi Kawana, Akihiko Itoyama, Satoru Kirikae, Teruo Kuratsuji, Tadatoshi Ohashi, Jun Quy, Tran Sasazuki, Takehiko Yanai, Hideki Dang Ha, Le Long, Hoang Phi, Nguyen Van Ban, Vo
Source	Elsevier; Medline; PMC
abstract	Abstract We have hypothesized that genetic predisposition influences the progression of SARS. Angiotensin converting enzyme (ACE1) insertion/deletion (I/D) polymorphism was previously reported to show association with the adult respiratory distress syndrome, which is also thought to play a key role in damaging the lung tissues in SARS cases. This time, the polymorphism was genotyped in 44 Vietnamese SARS cases, with 103 healthy controls who had had a contact with the SARS patients and 50 controls without any contact history. SARS cases were divided into either non-hypoxemic or hypoxemic groups. Despite the small sample size, the frequency of the D allele was significantly higher in the hypoxemic group than in the non-hypoxemic group (p =0.013), whereas there was no significant difference between the SARS cases and controls, irrespective of a contact history. ACE1 might be one of the candidate genes that influence the progression of pneumonia in SARS.
has issue date	2004-10-22(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2004.08.208
bibo:pmid	15381116
has license	els-covid
sha1sum (hex)	a26310448a2c11a83217bbe892b56c20534a7223
schema:url	https://doi.org/10.1016/j.bbrc.2004.08.208
resource representing a document's title	ACE1 polymorphism and progression of SARS
has PubMed Central identifier	PMC7092806
has PubMed identifier	15381116
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:a26310448a2c11a83217bbe892b56c20534a7223#body_text
is schema:about of	named entity 'POLYMORPHISM' named entity 'ACE1' named entity 'adult respiratory distress syndrome' named entity 'sample size' named entity 'Despite' named entity 'patients' named entity 'frequency' named entity 'controls' named entity 'TIME' named entity 'EITHER' named entity 'SAMPLE SIZE' named entity 'KEY' named entity 'ANGIOTENSIN CONVERTING ENZYME' named entity 'CASES' named entity 'SARS' named entity 'ALLELE' named entity 'PATIENTS' covid:arg/a26310448a2c11a83217bbe892b56c20534a7223 named entity 'THOUGHT' named entity 'REPORTED' named entity 'POLYMORPHISM' named entity 'PREVIOUSLY' named entity 'LUNG TISSUES' named entity 'VIETNAMESE' named entity 'SIGNIFICANT' named entity 'FREQUENCY' named entity 'CONTACT' named entity '28P' named entity 'ACE1' named entity 'ADULT RESPIRATORY DISTRESS SYNDROME' named entity 'PROGRESSION' named entity '28I' named entity 'DIVIDED' named entity 'HEALTHY' named entity 'CANDIDATE GENES' named entity 'PLAY' named entity 'DAMAGING' named entity '103' named entity 'SMALL' named entity 'INFLUENCE' named entity 'MIGHT BE' named entity 'CONTACT WITH' named entity 'ASSOCIATION' named entity 'HISTORY' named entity 'GENETIC PREDISPOSITION' named entity 'PNEUMONIA' named entity 'SARS' named entity 'PROGRESSION' named entity 'ROLE' named entity 'HAVE' named entity 'HIGHER' named entity 'ONE OF' named entity 'GROUP' named entity 'INSERTION' named entity 'GROUPS' named entity 'NON-' named entity 'DIFFERENCE' named entity 'influences' named entity 'genetic predisposition' named entity 'hypoxemic' named entity 'influence' named entity 'pneumonia' named entity 'sample size' named entity 'Angiotensin converting enzyme' named entity 'hypoxemic' named entity 'polymorphism' named entity 'allele'

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