About: First isolation of West Nile virus from a dromedary camel

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About: First isolation of West Nile virus from a dromedary camel Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	First isolation of West Nile virus from a dromedary camel
Creator	Huang, Yi Chan, Kwok-Hung Joseph, Sunitha Wernery, Renate Wernery, Ulrich Kinne, Jörg Elizabeth, Shyna Lau, Susanna Patteril, Nissy Woo, Patrick Ll Teng, Jade Yy Fan, Rachel
Source	Medline; PMC
abstract	Although antibodies against West Nile virus (WNV) have been detected in the sera of dromedaries in the Middle East, North Africa and Spain, no WNV has been isolated or amplified from dromedary or Bactrian camels. In this study, WNV was isolated from Vero cells inoculated with both nasal swab and pooled trachea/lung samples from a dromedary calf in Dubai. Complete-genome sequencing and phylogenetic analysis using the near-whole-genome polyprotein revealed that the virus belonged to lineage 1a. There was no clustering of the present WNV with other WNVs isolated in other parts of the Middle East. Within lineage 1a, the dromedary WNV occupied a unique position, although it was most closely related to other WNVs of cluster 2. Comparative analysis revealed that the putative E protein encoded by the genome possessed the original WNV E protein glycosylation motif NYS at E154–156, which contained the N-linked glycosylation site at N-154 associated with increased WNV pathogenicity and neuroinvasiveness. In the putative NS1 protein, the A70S substitution observed in other cluster 2 WNVs and P250, which has been implicated in neuroinvasiveness, were present. In addition, the foo motif in the putative NS2A protein, which has been implicated in neuroinvasiveness, was detected. Notably, the amino-acid residues at 14 positions in the present dromedary WNV genome differed from those in most of the closely related WNV strains in cluster 2 of lineage 1a, with the majority of these differences observed in the putative E and NS5 proteins. The present study is the first to demonstrate the isolation of WNV from dromedaries. This finding expands the possible reservoirs of WNV and sources of WNV infection.
has issue date	2016-06-08(xsd:dateTime)
bibo:doi	10.1038/emi.2016.53
bibo:pmid	27273223
has license	cc-by
sha1sum (hex)	a21f8d21e09607e555468d0ed155126daaeb37cd
schema:url	https://doi.org/10.1038/emi.2016.53
resource representing a document's title	First isolation of West Nile virus from a dromedary camel
has PubMed Central identifier	PMC4932647
has PubMed identifier	27273223
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:a21f8d21e09607e555468d0ed155126daaeb37cd#body_text
is schema:about of	named entity 'glycosylation' named entity 'protein' named entity 'demonstrate' named entity 'WNV' named entity 'encoded' named entity 'amplified' named entity 'WNV' named entity 'nasal' named entity 'WEST NILE VIRUS' named entity 'ISOLATION' named entity 'NS2A' named entity 'NEAR' named entity 'UNIQUE' named entity 'E PROTEIN' named entity 'WNV INFECTION' named entity 'HAVE' named entity 'NS1 PROTEIN' named entity 'P250' named entity 'SAMPLES' named entity 'SPAIN' named entity 'SUBSTITUTION' named entity 'CAMELS' named entity 'THESE' named entity 'TRACHEA' named entity 'CLUSTER' named entity 'POSITION' named entity 'PATHOGENICITY' named entity 'VIRUS' named entity 'MIDDLE EAST' named entity 'DUBAI' named entity 'POOLED' named entity 'ANTIBODIES' named entity 'GENOME' named entity 'RESERVOIRS' named entity 'DROMEDARY' named entity 'NYS' named entity 'ASSOCIATED WITH' named entity 'RELATED' named entity 'PRESENT' named entity 'ENCODED' named entity 'MAJORITY' named entity 'ISOLATED' named entity 'NORTH AFRICA' named entity 'COMPARATIVE ANALYSIS' named entity 'GENOME POLYPROTEIN' named entity 'PROTEIN ' named entity 'N-LINKED GLYCOSYLATION' named entity 'PROTEIN' named entity 'ISOLATION' named entity 'REVEALED' named entity 'AMPLIFIED' named entity 'LINEAGE' named entity 'MOTIF' named entity 'CALF' named entity 'DROMEDARIES' named entity 'WNV' named entity 'NEUROINVASIVENESS' named entity 'WEST NILE VIRUS' named entity 'DROMEDARY CAMEL' named entity 'PARTS' named entity 'INCREASED' named entity 'GLYCOSYLATION SITE' named entity '154' named entity 'ADDITION' named entity 'FINDING' named entity 'NS5' named entity 'ORIGINAL' named entity 'VERO CELLS' named entity 'POSSESSED' named entity 'PHYLOGENETIC ANALYSIS'

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