About: PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity
Creator	Kang, Rui Tang, Daolin Coyne, Carolyn Lotze, Michael Zeh, Herbert
Source	Medline; PMC
abstract	Pathogen-associated molecular pattern molecules (PAMPs) are derived from microorganisms and recognized by pattern recognition receptor (PRR)-bearing cells of the innate immune system as well as many epithelial cells. In contrast, damage-associated molecular pattern molecules (DAMPs) are cell-derived and initiate and perpetuate immunity in response to trauma, ischemia, and tissue damage, either in the absence or presence of pathogenic infection. Most PAMPs and DAMPs serve as so-called ‘Signal 0s’ that bind specific receptors [Toll-like receptors, NOD-like receptors, RIG-I-like receptors, AIM2-like receptors, and the receptor for advanced glycation end products (RAGE)] to promote autophagy. Autophagy, a conserved lysosomal degradation pathway, is a cell survival mechanism invoked in response to environmental and cellular stress. Autophagy is inferred to have been present in the last common eukaryotic ancestor and only to have been lost by some obligatory intracellular parasites. As such, autophagy represents a unifying biology, subserving survival and the earliest host defense strategies, predating apoptosis, within eukaryotes. Here, we review recent advances in our understanding of autophagic molecular mechanisms and functions in emergent immunity.
has issue date	2012-08-14(xsd:dateTime)
bibo:doi	10.1111/j.1600-065x.2012.01146.x
bibo:pmid	22889221
has license	green-oa
sha1sum (hex)	a20367cb96400a9e4dc0ca3c8dbc4c30fc764052
schema:url	https://doi.org/10.1111/j.1600-065x.2012.01146.x
resource representing a document's title	PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity
has PubMed Central identifier	PMC3662247
has PubMed identifier	22889221
schema:publication	Immunological Reviews
resource representing a document's body	covid:a20367cb96400a9e4dc0ca3c8dbc4c30fc764052#body_text
is schema:about of	named entity 'receptors' named entity 'Pathogen-associated molecular pattern' named entity 'LOST' named entity 'RECENT' named entity 'PATTERN RECOGNITION RECEPTOR' named entity 'INITIATE' named entity 'ANCESTOR' named entity 'PROMOTE' named entity 'EUKARYOTES' named entity 'PRESENT' named entity 'DAMAGE-ASSOCIATED MOLECULAR PATTERN' named entity 'CELLS' named entity 'infection' named entity 'damage' named entity 'innate immune system' named entity 'NOD-like receptors' named entity 'RAGE' named entity 'microorganisms' named entity 'PAMPs' named entity 'inferred' named entity 'degradation' named entity 'cell' named entity 'autophagy' named entity 'immunity' named entity 'innate immune' named entity 'RAGE' named entity 'AIM2' named entity 'Autophagy' named entity 'apoptosis' named entity 'autophagy' named entity 'RIG-I' named entity 'host defense' named entity 'PAMPs' named entity 'DAMPs' named entity 'survival mechanism' named entity 'bacteria' named entity 'Dectin-1' named entity 'autophagy' named entity 'Atg14' named entity 'shRNA' named entity 'nucleotide-binding' named entity 'peptides' named entity 'macrophages' named entity 'DAMPs' named entity 'MyD88' named entity 'FLICE' named entity 'signal transduction pathways' named entity 'pro-inflammatory cytokine' named entity 'CpG' named entity 'Atg6' named entity 'exogenous' named entity 'Drosophila' named entity 'LPS-dependent' named entity 'HMGB1' named entity 'TLR4' named entity 'autophagy' named entity 'PRRs' named entity 'mTOR' named entity 'Autophagy' named entity 'macrophages' named entity 'infection' named entity 'ATG16L1' named entity 'foreign antigens' named entity 'hyaluronic acid' named entity 'kinase' named entity 'extrinsic pathway' named entity 'protein' named entity 'endocytosis' named entity 'autophagic' named entity 'LPS' named entity 'FOXO3' named entity 'type I IFN' named entity 'extracellular signal-regulated kinase' named entity 'IL-1b' named entity 'MDA5' named entity 'oxidases' named entity 'DAMP'

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