About: Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies
Creator	Nematy, Mohsen Rezvani, Reza Safarian, Mohammad Sedaghat, Alireza Khadem-Rezaian, Majid Seifi, Najmeh
Source	PMC
abstract	BACKGROUND: An extreme and persistent dysbiosis occurs among critically ill patients, regardless of the heterogeneity of disease. Dysbiosis in critically ill patients may make them prone to hospital-acquired infections, sepsis, multi-organ failure (MOF), energy homeostasis disturbance, muscle wasting, and cachexia. Modulation of gut microbiota through synbiotics can be considered as a potential treatment for muscle wasting and macronutrient homeostasis disturbances. METHODS: This is a prospective, single-center, double-blind, parallel randomized controlled trial with the aim to evaluate the effects of synbiotic supplementation on energy and macronutrient homeostasis and muscle wasting in critically ill patients. A total of 40 hemodynamically stable, adult, critically ill patients who receive enteral nutrition via a nasogasteric tube (NGT) in the 24–48 h after admission to critical care will be included in this study. Eligible patients will be randomly assigned to receive Lactocare (ZistTakhmir) capsules 500 mg every 12 h or a placebo capsule, which contains only the sterile maize starch and is similar to synbiotic capsules for 14 days. The synbiotic and placebo capsules will be given through the nasogastric tube, separately from gavage, after feeding. DISCUSSION: Gut microbiota modulation through synbiotics is proposed to improve clinical prognosis and reduce infectious complications, ventilator dependency, and length of ICU stay by improving energy and macronutrient homeostasis and reducing muscle protein catabolism. TRIAL REGISTRATION: Iranian Registry of Clinical Trials, IRCT20190227042857N1. Registered on 17 March 2019.
has issue date	2020-02-24(xsd:dateTime)
bibo:doi	10.1186/s13063-020-4136-3
bibo:pmid	32093741
has license	cc-by
sha1sum (hex)	a1fe58cd0decb70c80b2c4a309e52aa4e1dcf4f6
schema:url	https://doi.org/10.1186/s13063-020-4136-3
resource representing a document's title	Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies
has PubMed Central identifier	PMC7041281
has PubMed identifier	32093741
schema:publication	Trials
resource representing a document's body	covid:a1fe58cd0decb70c80b2c4a309e52aa4e1dcf4f6#body_text
is schema:about of	named entity 'homeostasis' named entity 'extreme' named entity 'energy' named entity 'studies' named entity 'dysbiosis' named entity 'critically ill' named entity 'muscle wasting' named entity 'muscle wasting' named entity 'critically ill patients' named entity 'homeostasis' named entity 'synbiotics' named entity 'prebiotic' named entity 'creatinine' named entity 'metabolites' named entity 'nitrogen' named entity 'alanine aminotransferase' named entity 'residual volume' named entity 'glycerol kinase' named entity 'microbial' named entity 'informed consent' named entity 'urine' named entity 'creatinine' named entity 'light chain' named entity 'Gene transfer' named entity 'Gut microbiota' named entity 'calorie' named entity 'probiotics' named entity 'probiotics' named entity 'Pressure ulcer' named entity 'magnesium' named entity 'muscle wasting' named entity 'microbial community' named entity 'leukemic' named entity 'luminal' named entity 'cachexia' named entity 'informed consent' named entity 'energy homeostasis' named entity 'pregnancy' named entity 'Kcal/kg' named entity '0.9' named entity 'cell metabolism' named entity 'mouse models' named entity 'Gut microbiota' named entity 'critical care' named entity '11.6' named entity 'placebo' named entity 'NF-kB' named entity 'lipopolysaccharides' named entity 'gram-negative bacteria' named entity 'synbiotic' named entity 'neutrophil' named entity 'protein' named entity 'muscle wasting' named entity 'creatinine' named entity 'gut microbiota' named entity 'systemic inflammation' named entity 'gut microbiota' named entity 'metabolism' named entity 'muscle wasting' named entity 'Nutritional status' named entity 'short-chain fatty acids' named entity 'critical care' named entity 'nitrogen balance' named entity 'muscle mass' named entity 'calorie' named entity 'protein' named entity 'protein' named entity 'commensal' named entity 'antibiotic' named entity 'probiotics' named entity 'transcription factor' named entity 'MedCalc' named entity 'nuclear factor' named entity 'Animal studies' named entity 'leukemia' named entity 'prebiotics'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software