About: Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities
Creator	Liu, Xinyong Zhan, Peng Abdi, Fatemeh Cocklin, Simon Dick, Alexej Ju, Han Mirzaie, Sako Xiu, Siyu
source	Medline; PMC
abstract	[Image: see text] Recently, a novel coronavirus initially designated 2019-nCoV but now termed SARS-CoV-2 has emerged and raised global concerns due to its virulence. SARS-CoV-2 is the etiological agent of “coronavirus disease 2019”, abbreviated to COVID-19, which despite only being identified at the very end of 2019, has now been classified as a pandemic by the World Health Organization (WHO). At this time, no specific prophylactic or postexposure therapy for COVID-19 are currently available. Viral entry is the first step in the SARS-CoV-2 lifecycle and is mediated by the trimeric spike protein. Being the first stage in infection, entry of SARS-CoV-2 into host cells is an extremely attractive therapeutic intervention point. Within this review, we highlight therapeutic intervention strategies for anti-SARS-CoV, MERS-CoV, and other coronaviruses and speculate upon future directions for SARS-CoV-2 entry inhibitor designs.
has issue date	2020-06-15(xsd:dateTime)
bibo:doi	10.1021/acs.jmedchem.0c00502
bibo:pmid	32539378
has license	no-cc
sha1sum (hex)	a1d2d63dada41cefc3933c9777b2fac8b503fe06
schema:url	https://doi.org/10.1021/acs.jmedchem.0c00502
resource representing a document's title	Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities
has PubMed Central identifier	PMC7315836
has PubMed identifier	32539378
schema:publication	J Med Chem
resource representing a document's body	covid:a1d2d63dada41cefc3933c9777b2fac8b503fe06#body_text
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