About: Oxidative stress markers in neonatal respiratory distress syndrome: advanced oxidation protein products and 8-hydroxy-2-deoxyguanosine in relation to disease severity

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About: Oxidative stress markers in neonatal respiratory distress syndrome: advanced oxidation protein products and 8-hydroxy-2-deoxyguanosine in relation to disease severity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Oxidative stress markers in neonatal respiratory distress syndrome: advanced oxidation protein products and 8-hydroxy-2-deoxyguanosine in relation to disease severity
Creator	El-Farrash, Rania Elkabany, Zeinab Elsayed, Medhat Farag, Ahmed Gaballah, Saleh Ismail, Eman Macken, Eman Nada, Ahmed Salama, Dina Shinkar, Dina
Source	PMC
abstract	OBJECTIVE: We assessed oxidant–antioxidant status and evaluated the role of lipid peroxidation, oxidative DNA damage, and protein oxidation in the development and severity of neonatal respiratory distress syndrome (RDS). METHODS: Forty preterm neonates with RDS were compared with another 40 preterm neonates without RDS enrolled as controls. Total antioxidant capacity (TAC), malondialdehyde (MDA), advanced oxidation protein products (AOPPs), 8-hydroxy-2-deoxyguanosine (8-OHdG), and trace elements (copper and zinc) were measured in cord blood (day 0) for all neonates and repeated on day 3 for the RDS group. RESULTS: Day 0 serum levels of MDA, AOPPs, and 8-OHdG were significantly higher in neonates with RDS than controls with a further increase on day 3. Days 0 and 3 levels of TAC, copper, and zinc were significantly lower in the RDS group compared with controls. Elevated serum levels of 8-OHdG and AOPPs were associated with severe RDS, invasive mechanical ventilation, and high mortality rate. 8-OHdG and AOPPs were positively correlated with MDA, oxygenation index, duration of ventilation, and duration of hospitalization. CONCLUSIONS: Increased lipid, protein, and DNA oxidation is accompanied by alterations in the antioxidant defense status, which may play a role in the pathogenesis and severity of RDS.
has issue date	2019-06-19(xsd:dateTime)
bibo:doi	10.1038/s41390-019-0464-y
bibo:pmid	31216566
has license	no-cc
sha1sum (hex)	a1cd7836c9dde7f907d255de55ca291d9e66003a
schema:url	https://doi.org/10.1038/s41390-019-0464-y
resource representing a document's title	Oxidative stress markers in neonatal respiratory distress syndrome: advanced oxidation protein products and 8-hydroxy-2-deoxyguanosine in relation to disease severity
has PubMed Central identifier	PMC7223063
has PubMed identifier	31216566
schema:publication	Pediatr Res
resource representing a document's body	covid:a1cd7836c9dde7f907d255de55ca291d9e66003a#body_text
is schema:about of	named entity 'products' named entity 'malondialdehyde' named entity 'repeated' named entity 'DNA oxidation' named entity 'severe' named entity 'neonates' named entity 'respiratory distress' named entity 'OXIDATIVE STRESS' covid:arg/a1cd7836c9dde7f907d255de55ca291d9e66003a named entity 'pathogenesis' named entity 'serum' named entity 'neonates' named entity 'antioxidant' named entity 'hospitalization' named entity 'zinc' named entity 'duration' named entity 'mechanical ventilation' named entity 'neonates' named entity 'mortality rate' named entity 'accompanied' named entity '8-OHdG' named entity 'neonatal respiratory distress syndrome' named entity 'RDS' named entity 'TAC' named entity '8-OHdG' named entity 'RDS' named entity 'RDS' named entity 'Total antioxidant capacity' named entity 'copper' named entity 'oxidation' named entity 'positively correlated' named entity 'RDS' named entity 'serum levels' named entity 'advanced oxidation' named entity '8-OHdG' named entity 'RDS' named entity 'oxidative DNA damage' named entity 'protein products' named entity 'deoxyguanosine' named entity 'neonatal respiratory distress syndrome' named entity 'maternal diseases' named entity 'control group' named entity 'ROS' named entity 'lung' named entity 'zinc' named entity 'IL-6' named entity 'hydroperoxide' named entity 'RDS' named entity 'neonates' named entity 'premature rupture of membranes' named entity 'carbonyl' named entity 'birth weight' named entity 'gestational age' named entity 'RDS' named entity 'colorimetric' named entity 'reactive oxygen species' named entity 'zinc' named entity 'oxidative stress' named entity 'protein' named entity 'assay' named entity 'gestational age' named entity 'statistical power' named entity 'RDS' named entity 'RDS' named entity 'biomarkers' named entity 'lipid peroxidation' named entity 'colorimetric' named entity 'Informed consent' named entity 'patent ductus arteriosus' named entity 'pulmonary hypertension' named entity 'premature infants' named entity 'clinical characteristics'

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