About: Dietary 25-Hydroxyvitamin D(3) Supplementation Alleviates Porcine Epidemic Diarrhea Virus Infection by Improving Intestinal Structure and Immune Response in Weaned Pigs

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About: Dietary 25-Hydroxyvitamin D(3) Supplementation Alleviates Porcine Epidemic Diarrhea Virus Infection by Improving Intestinal Structure and Immune Response in Weaned Pigs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Dietary 25-Hydroxyvitamin D(3) Supplementation Alleviates Porcine Epidemic Diarrhea Virus Infection by Improving Intestinal Structure and Immune Response in Weaned Pigs
Creator	Yu, Jie Chen, Daiwen He, Jun Huang, Zhiqing Luo, Junqiu Luo, Yuheng Mao, Xiangbing Wu, Aimin Yu, Bing Zheng, Ping Tian, Gang Yang, Jiwen
source	PMC
abstract	SIMPLE SUMMARY: Porcine epidemic diarrhea is one of the major problems in current swine husbandry worldwide, and effective measures for prevention and treatment are scarce. We found that high dose 25-hydroxyvitamin D(3) supplementation could ease intestinal injury and inhibit intestinal immune response induced by porcine epidemic diarrhea virus (PEDV), suggesting that feeding a high dose of 25-hydroxyvitamin D(3) could be used as an approach against PEDV infection. ABSTRACT: We conducted this experiment to determine if feeding 25-hydroxyvitamin D(3) (25(OH)D(3)) to weaned pigs would alleviate porcine epidemic diarrhea virus (PEDV) infection and immune response. Forty-two weaned pigs were allotted to 1 of 6 dietary 25(OH)D(3) treatments (5.5, 5.5, 43.0, 80.5, 118.0, 155.5 μg 25(OH)D(3)/kg diet) for 26 days. On day 22 of the trial, all the treatments were orally administrated with PEDV except for one of the 5.5 μg 25(OH)D(3)/kg treatments, which was challenged with the same volume of sterile saline and served as control. Another 5.5 μg 25(OH)D(3)/kg group for PEDV challenge was named CON-PEDV. Average daily gain (p < 0.05) was reduced by PEDV infection. PEDV administration also induced severe diarrhea (p < 0.05), reduction of villous height and the ratio of villous height to crypt depth, and increase of crypt depth and serum diamine oxidase activity (p < 0.05). Serum IgM and complement component 4 levels were increased by PEDV challenge. However, 155.5 μg 25(OH)D(3)/kg supplementation alleviated intestinal damage (p < 0.05) compared with CON-PEDV. Furthermore, 155.5 μg 25(OH)D(3)/kg supplementation downregulated the mRNA abundance of inflammatory cytokines and interferon signal pathway-related genes (p < 0.05) compared with CON-PEDV. These results suggested that dietary supplementation of 155.5 μg 25(OH)D(3)/kg could alleviate intestinal damage and protect against PEDV-induced inflammatory status.
has issue date	2019-08-29(xsd:dateTime)
bibo:doi	10.3390/ani9090627
bibo:pmid	31470619
has license	cc-by
sha1sum (hex)	a1c0ce2d5b6132eb41c6c7339b211655c8460e1a
schema:url	https://doi.org/10.3390/ani9090627
resource representing a document's title	Dietary 25-Hydroxyvitamin D(3) Supplementation Alleviates Porcine Epidemic Diarrhea Virus Infection by Improving Intestinal Structure and Immune Response in Weaned Pigs
has PubMed Central identifier	PMC6770734
has PubMed identifier	31470619
schema:publication	Animals (Basel)
resource representing a document's body	covid:a1c0ce2d5b6132eb41c6c7339b211655c8460e1a#body_text
is schema:about of	named entity 'current' named entity 'Infection' named entity 'INTESTINAL STRUCTURE' covid:arg/a1c0ce2d5b6132eb41c6c7339b211655c8460e1a named entity 'dose' named entity '25-hydroxyvitamin D' named entity 'immune response' named entity 'feeding' named entity 'immune response' named entity 'porcine epidemic diarrhea virus' named entity 'high dose' named entity 'PEDV' named entity 'Immune Response' named entity 'Weaned' named entity 'Porcine' named entity 'serum' named entity 'infection' named entity 'Shanghai' named entity 'villous' named entity 'VCR' named entity 'basal' named entity 'PEDV' named entity 'morphological' named entity 'bioavailability' named entity 'dietary supplementation' named entity 'antiviral effect' named entity 'diarrhea' named entity 'inoculated' named entity 'PEDV' named entity 'intestinal barrier' named entity 'STAT1' named entity 'jejunal' named entity 'VCR' named entity 'IL8' named entity 'ad libitum' named entity 'PEDV' named entity 'villous' named entity 'infection' named entity '25(OH)D' named entity 'PEDV' named entity 'hematoxylin and eosin' named entity 'tissue sample' named entity 'jejunum' named entity 'severe diarrhea' named entity 'infection' named entity 'jejunum' named entity 'intestinal barrier' named entity 'TLR9' named entity 'Dalian' named entity 'infection' named entity 'mucosa' named entity 'ADFI' named entity 'intestinal mucosa' named entity 'administrated' named entity 'Hitachi' named entity 'challenge groups' named entity 'crossbred' named entity 'dietary supplementation' named entity 'MDA5' named entity 'IgG' named entity 'gene' named entity 'epithelium' named entity 'IFNAR1' named entity '25(OH)D' named entity 'premix' named entity 'body weight' named entity 'China' named entity 'PEDV' named entity 'infection' named entity '25(OH)D'

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