About: Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma

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About: Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma
Creator	Alcantara-Neves, Neuza Cruz, Álvaro Figueiredo, Camila Galvão, Alana Borges, Maria De Araújo Sena, Flávia De Santana, Rabelo Lima Barreto, Maurício Medeiros De Andrade Belitardo, Emília Nunes De Oliveira Costa, Gustavo Santos Costa, Ryan Dos
source	PMC
abstract	BACKGROUND: Vitamin D deficiency or insufficiency, has been associated with atopy and lack of asthma control. Our objective was to investigate associations between variants in genes of vitamin D pathway with serum levels of 25-hydroxyvitamin D (25(OH)D), atopy, asthma and asthma severity in teenagers from Northeast Brazil. METHODS: This is a cross sectional study nested in a cohort population of asthma. 25(OH)D was quantified from 968 of 11–17 years old individuals by ELISA. Asthma diagnosis was obtained by using the ISAAC Phase III questionnaire. Specific IgE was determined by ImmunoCAP; genotyping was performed using the 2.5 HumanOmni Biochip from Illumina. Statistical analyses were performed in PLINK 1.07 and SPSS 22.1. RESULTS: After quality control, 104 Single Nucleotides Variants (SNVs) in vitamin D pathway genes, typed in 792 individuals, were included in the analysis. The allele A of rs10875694 on VDR was positively associated with atopy (OR = 1.35; 95% CI 1.01–1.81). The allele C of rs9279 on VDR, was negatively associated with asthma risk (OR = 0.66; 95% CI 0.45–0.97), vitamin D insufficiency (OR = 0.78; 95% CI 0.70–0.96) and higher VDR expression. Two variants in VDR were associated with asthma severity, the allele A of rs2189480 (OR = 0.34; 95% CI 0.13–0.89) and the allele G of rs4328262 (OR = 3.18; 95% CI 1.09–9.28). The combination of variants in CYP2R1 and CYP24A1 (GAC, to rs10500804, rs12794714 and rs3886163, respectively) was negatively associated with vitamin D production (β = − 1.24; 95% CI − 2.42 to − 0.06). CONCLUSIONS: Genetic variants in the vitamin D pathway affect vitamin D serum levels and, thus, atopy and asthma.
has issue date	2020-07-09(xsd:dateTime)
bibo:doi	10.1186/s13223-020-00460-y
has license	cc-by
sha1sum (hex)	a152087e07c0cc5af17ba142d8965f0a4b290b59
schema:url	https://doi.org/10.1186/s13223-020-00460-y
resource representing a document's title	Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma
has PubMed Central identifier	PMC7386242
schema:publication	Allergy Asthma Clin Immunol
resource representing a document's body	covid:a152087e07c0cc5af17ba142d8965f0a4b290b59#body_text
is schema:about of	named entity 'influence' named entity 'VITAMIN D PATHWAY' named entity 'OBJECTIVE' named entity 'LACK' named entity 'Northeast Brazil' named entity 'Vitamin D deficiency' named entity 'asthma' named entity 'eosinophilic' named entity 'gene' named entity 'Arabic' named entity 'molecule' named entity 'asthma' named entity 'CYP2R1' named entity 'chromosome 12' named entity 'serum levels' named entity '25(OH)D' named entity 'asthma' named entity 'allele' named entity 'atopy' named entity 'allergens' named entity 'Th2' named entity 'CYP24A1' named entity 'vitamin' named entity 'asthmatics' named entity 'allele' named entity 'SNVs' named entity 'asthma' named entity 'VDR' named entity 'allele' named entity 'metabolism' named entity 'gene expression' named entity 'asthma' named entity 'asthma' named entity 'gene expression' named entity 'CYP2R1' named entity '25(OH)D' named entity 'active metabolite' named entity 'SNV' named entity 'SNV' named entity 'asthma exacerbation' named entity 'statistically significant' named entity 'gene expression' named entity 'polymorphism' named entity 'mucus' named entity 'metabolism' named entity 'Brazil' named entity 'vitamin D levels' named entity 'lymphocyte' named entity '25(OH)D' named entity 'atopy' named entity 'vitamin' named entity 'alleles' named entity 'East Asian' named entity '25(OH)D' named entity 'vitamin D levels' named entity 'Type 2 diabetes' named entity 'Allele' named entity 'TNFSF4' named entity 'atopy' named entity 'gene transcription' named entity 'tropical climate' named entity 'vitamin' named entity 'Allergic' named entity 'serum levels' named entity 'forced vital capacity' named entity 'peripheral blood' named entity 'polymorphism' named entity 'VDR' named entity 'vitamin' named entity 'IL2RB' named entity 'IL-4' named entity 'vitamin D3' named entity 'VDRE'

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