About: Galloyl-Hexahydroxydiphenoyl (HHDP)-Glucose Isolated From Punica granatum L. Leaves Protects Against Lipopolysaccharide (LPS)-Induced Acute Lung Injury in BALB/c Mice

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About: Galloyl-Hexahydroxydiphenoyl (HHDP)-Glucose Isolated From Punica granatum L. Leaves Protects Against Lipopolysaccharide (LPS)-Induced Acute Lung Injury in BALB/c Mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Galloyl-Hexahydroxydiphenoyl (HHDP)-Glucose Isolated From Punica granatum L. Leaves Protects Against Lipopolysaccharide (LPS)-Induced Acute Lung Injury in BALB/c Mice
Creator	Falcai, Angela Augusto, Marco Bittencourt-Mernak, Márcia Cortez De Sá, Joicy Costa, Matheus Dara, Milena De, Farias Fontes, Valéria Gonçalves Lima-Neto, Lidio Grisoto, Gregolin Henrique, João Joaquim, Aruanã Lago, G Martin, Lukas Martins De Sousa, Eduardo Mendes, Santos Neves, Jesus Paula, Fernanda Pinheiro, Rodrigues Prado, Carla Quintino Da Rocha, Claudia Ricardo, Aleff Santana, Roncon Sordi, Regina Thiemermann, Christoph
source	PMC
abstract	The hydroalcoholic extract and ethyl acetate fraction of Punica granatum leaves have been known to exhibit anti-inflammatory activities. In this study, we investigated the therapeutic effects of galloyl-hexahydroxydiphenoyl (HHDP)-glucose isolated from pomegranate leaves on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. Male BALB/c mice were treated with different doses of galloyl-HHDP-glucose (5, 50, and 100 mg/Kg) or dexamethasone at 5 mg/Kg (per os) 6 h after intra-tracheal instillation of LPS. Vehicle-treated mice were used as controls. Twenty-four hours after LPS challenge, bronchoalveolar lavage fluid (BALF), and lung samples were collected for analyses. They were evaluated by monitoring the expression of NF-κB, JNK, and cytokine genes and proteins, as well as cell migration and lung function. All doses of galloyl-HHDP-glucose inhibited LPS-induced JNK and NF-κB activation. Likewise, the galloyl-HHDP-glucose-treated animals presented reduced expression of the TNF-α, IL-6, and IL-1β genes in the lungs and reduced TNF-α, IL-6, IL-1β, and IL-8 protein levels when compared with the vehicle-treated LPS-challenged mice. In addition, the ALI mice treated with galloyl-HHDP-glucose also presented reduced lung inflammatory cell accumulation, especially that of neutrophils, in their BALF and lungs. In addition, galloyl-HHDP-glucose treatment markedly ameliorated the LPS-induced pulmonary mechanism complications and attenuated weight loss. Overall, we showed for the first time that galloyl-HHDP-glucose protects against ALI, and may be useful for treating ALI and other inflammatory disorders.
has issue date	2019-08-20(xsd:dateTime)
bibo:doi	10.3389/fimmu.2019.01978
bibo:pmid	31481965
has license	cc-by
sha1sum (hex)	a11d517c9cdd68c3671429751ed8420fb9fc1485
schema:url	https://doi.org/10.3389/fimmu.2019.01978
resource representing a document's title	Galloyl-Hexahydroxydiphenoyl (HHDP)-Glucose Isolated From Punica granatum L. Leaves Protects Against Lipopolysaccharide (LPS)-Induced Acute Lung Injury in BALB/c Mice
has PubMed Central identifier	PMC6710369
has PubMed identifier	31481965
schema:publication	Front Immunol
resource representing a document's body	covid:a11d517c9cdd68c3671429751ed8420fb9fc1485#body_text
is schema:about of	named entity 'presented' named entity 'genes' named entity 'activities' named entity 'LPS' covid:arg/a11d517c9cdd68c3671429751ed8420fb9fc1485 named entity 'leaves' named entity 'compared' named entity 'ALI' named entity 'ethyl acetate' named entity 'isolated' named entity 'All' named entity 'LPS' named entity 'IL-8' named entity 'BALF' named entity 'animals' named entity 'neutrophils' named entity 'lung' named entity 'genes' named entity 'presented' named entity 'IL-6' named entity 'IL-1β' named entity 'NF-κB' named entity 'Mice' named entity 'BALF' named entity 'therapeutic effects' named entity 'mice' named entity 'JNK' named entity 'pomegranate' named entity 'tracheal' named entity 'LPS' named entity 'inflammatory cell' named entity 'TNF-α' named entity 'galloyl' named entity 'galloyl' named entity 'IL-1β' named entity 'glucose' named entity 'mice' named entity 'neutrophils' named entity 'lipopolysaccharide' named entity 'Galloyl' named entity 'cytokine' named entity '20S' named entity 'histological analysis' named entity 'galloyl' named entity 'LPS' named entity 'galloyl' named entity 'inflammation' named entity 'chromatography' named entity 'pharmacological activities' named entity 'galloyl' named entity 'mice' named entity 'cDNA' named entity 'glucose' named entity 'Valencia, CA' named entity 'neutrophils' named entity 'homogenates' named entity 'Eucalyptus globulus'

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