About: Coronavirus Disease 2019

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coronavirus Disease 2019–COVID-19
Creator	Dhama, Kuldeep Tiwari, Ruchi Bhat, Sudipta Sircar, Shubhankar Chaicumpa, Wanpen Katterine Bonilla-Aldana, D Rodriguez-Morales, Alfonso Sansthan, Anusandhan Singh, Yashpal Dayal, Deen Pandit, Pradesh Singh, Karam Khan, Sharun Chikitsa, Upadhyaya Go, Evam Vishwavidyalaya, Vigyan
Source	Medline; PMC; WHO
abstract	In recent decades, several new diseases have emerged in different geographical areas, with pathogens including Ebola virus, Zika virus, Nipah virus, and coronaviruses (CoVs). Recently, a new type of viral infection emerged in Wuhan City, China, and initial genomic sequencing data of this virus do not match with previously sequenced CoVs, suggesting a novel CoV strain (2019-nCoV), which has now been termed severe acute respiratory syndrome CoV-2 (SARS-CoV-2). Although coronavirus disease 2019 (COVID-19) is suspected to originate from an animal host (zoonotic origin) followed by human-to-human transmission, the possibility of other routes should not be ruled out. Compared to diseases caused by previously known human CoVs, COVID-19 shows less severe pathogenesis but higher transmission competence, as is evident from the continuously increasing number of confirmed cases globally. Compared to other emerging viruses, such as Ebola virus, avian H7N9, SARS-CoV, and Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has shown relatively low pathogenicity and moderate transmissibility. Codon usage studies suggest that this novel virus has been transferred from an animal source, such as bats. Early diagnosis by real-time PCR and next-generation sequencing has facilitated the identification of the pathogen at an early stage. Since no antiviral drug or vaccine exists to treat or prevent SARS-CoV-2, potential therapeutic strategies that are currently being evaluated predominantly stem from previous experience with treating SARS-CoV, MERS-CoV, and other emerging viral diseases. In this review, we address epidemiological, diagnostic, clinical, and therapeutic aspects, including perspectives of vaccines and preventive measures that have already been globally recommended to counter this pandemic virus.
has issue date	2020-06-24(xsd:dateTime)
bibo:doi	10.1128/cmr.00028-20
bibo:pmid	32580969
has license	no-cc
sha1sum (hex)	a1197616d3b03b84564639159f999321c601a01e
schema:url	https://doi.org/10.1128/cmr.00028-20
resource representing a document's title	Coronavirus Disease 2019–COVID-19
has PubMed Central identifier	PMC7405836
has PubMed identifier	32580969
schema:publication	Clin Microbiol Rev
resource representing a document's body	covid:a1197616d3b03b84564639159f999321c601a01e#body_text
is schema:about of	named entity 'Disease' named entity 'COVID-19' named entity 'S protein' named entity 'HR2' named entity 'COVID-19' named entity 'respiratory diseases' named entity 'epithelial cell' named entity 'virus' named entity 'emerging virus' named entity 'RBD' named entity 'live attenuated vaccines' named entity 'highly conserved' named entity 'reservoir host' named entity 'pathogens' named entity 'COVID' named entity 'incidence rates' named entity 'receptor' named entity 'SARS-CoV-2' named entity 'MERS-CoV' named entity 'ritonavir' named entity 'human beings' named entity 'pneumonia' named entity 'COVID-19' named entity 'horseshoe bat' named entity 'COVID' named entity 'bat' named entity 'neuraminidase inhibitors' named entity 'wet markets' named entity 'gastrointestinal tract' named entity 'mammals' named entity 'bronchoalveolar lavage fluid' named entity 'low-income countries' named entity 'IgM' named entity 'virus' named entity 'oseltamivir' named entity 'SARS-CoV-2' named entity 'pharyngeal' named entity 'biological activity' named entity 'antiviral drugs' named entity 'reservoir host' named entity 'wet market' named entity 'prevent the spread' named entity 'genetic material' named entity 'genome' named entity 'receptor' named entity 'bat' named entity 'SARS-CoV-2' named entity 'MERS-CoV' named entity 'infection' named entity 'COVID-19' named entity 'ivermectin' named entity 'next-generation sequencing' named entity 'Ebola virus' named entity 'titer' named entity 'BCG vaccination' named entity 'genetic sequence' named entity 'S protein' named entity 'prophylactic' named entity 'RT-PCR' named entity 'bronchoalveolar lavage fluid' named entity 'plasma' named entity 'Mycobacterium bovis' named entity 'cell culture' named entity 'enteritis' named entity 'structural proteins' named entity 'nucleocapsid'

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