About: Severe Human Lower Respiratory Tract Illness Caused by Respiratory Syncytial Virus and Influenza Virus Is Characterized by the Absence of Pulmonary Cytotoxic Lymphocyte Responses

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About: Severe Human Lower Respiratory Tract Illness Caused by Respiratory Syncytial Virus and Influenza Virus Is Characterized by the Absence of Pulmonary Cytotoxic Lymphocyte Responses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Severe Human Lower Respiratory Tract Illness Caused by Respiratory Syncytial Virus and Influenza Virus Is Characterized by the Absence of Pulmonary Cytotoxic Lymphocyte Responses
Creator	Ogra, Pearay Garofalo, Roberto Reed, Jennifer Avendano, Luis Chavez-Bueno, Susana Hintz, Karen Hosakote, Yashoda Jafri, Hasan Mckinney, Luann Sanchez, Katherine Velozo, Luis Welliver, Robert Welliver, Timothy
source	Medline; PMC
abstract	Background. Respiratory syncytial virus (RSV) and influenza virus are common causes of infantile lower respiratory tract infection (LRTI). It is widely believed that both viral replication and inappropriately enhanced immune responses contribute to disease severity. In infants, RSV LRTI is known to be more severe than influenza virus LRTI. Methods. We compared cytokines and chemokines in secretions of infants surviving various forms of respiratory illness caused by RSV or influenza viruses, to determine which mediators were associated with more-severe illness. We analyzed lung tissue from infants with fatal cases of RSV and influenza virus LRTI to determine the types of inflammatory cells present. Autopsy tissues were studied for the lymphotoxin granzyme and the apoptosis marker caspase 3. Results. Quantities of lymphocyte-derived cytokines were minimal in secretions from infants with RSV infection. Concentrations of most cytokines were greater in influenza virus, rather than RSV, infection. Lung tissues from infants with fatal RSV and influenza virus LRTI demonstrated an extensive presence of viral antigen and a near absence of CD8-positive lymphocytes and natural killer cells, with marked expression of markers of apoptosis. Conclusions. Severe infantile RSV and influenza virus LRTI is characterized by inadequate (rather than excessive) adaptive immune responses, robust viral replication, and apoptotic crisis.
has issue date	2007-04-15(xsd:dateTime)
bibo:doi	10.1086/512615
bibo:pmid	17357048
has license	no-cc
sha1sum (hex)	a08f5c095124c8c9b60c4103135ad06dc5511c6d
schema:url	https://doi.org/10.1086/512615
resource representing a document's title	Severe Human Lower Respiratory Tract Illness Caused by Respiratory Syncytial Virus and Influenza Virus Is Characterized by the Absence of Pulmonary Cytotoxic Lymphocyte Responses
has PubMed Central identifier	PMC7109876
has PubMed identifier	17357048
schema:publication	J Infect Dis
resource representing a document's body	covid:a08f5c095124c8c9b60c4103135ad06dc5511c6d#body_text
is schema:about of	named entity 'believed' named entity 'virus' named entity 'infection' named entity 'Respiratory Syncytial Virus' covid:arg/a08f5c095124c8c9b60c4103135ad06dc5511c6d named entity 'disease' named entity 'RSV' named entity 'influenza virus' named entity 'viral replication' named entity 'LRTI' named entity 'Respiratory Syncytial Virus' named entity 'Influenza Virus' named entity 'RSV' named entity 'RSV' named entity 'IL-12' named entity 'TNF-a' named entity 'LRTI' named entity 'lymphocyte' named entity 'toxin' named entity 'lymphocyte' named entity 'lymphocyte' named entity 'LRTI' named entity 'IL-4' named entity 'lymphocyte' named entity 'peripheral blood lymphocytes' named entity 'hospital stays' named entity 'CCL4' named entity 'lung tissue' named entity 'MCP-1' named entity 'cytokine' named entity 'IL-5' named entity 'apoptosis' named entity 'influenza virus' named entity 'vaccine' named entity 'IL-8' named entity 'granulocyte' named entity 'staining' named entity 'IL-1b' named entity 'respiratory tract' named entity 'LRTI' named entity 'CCL2' named entity 'cytokines' named entity 'respiratory epithelium' named entity 'immune responses' named entity 'Granzyme' named entity 'LRTI' named entity 'NK cell' named entity 'bronchiolar epithelium' named entity 'TNF-a' named entity 'congenital heart disease' named entity 'bronchiolitis' named entity 'viruses' named entity 'RSV infection' named entity 'pathogenesis' named entity 'IL-6' named entity 'statistically significant' named entity 'IL-2' named entity 'CD56' named entity 'follow-up' named entity 'caspase 3' named entity 'IFN-g' named entity 'LRTI' named entity 'neutrophils' named entity 'RSV infection' named entity 'innate immune responses' named entity 'influenza virus' named entity 'exudates' named entity 'RSV' named entity 'lymphoproliferative'

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