About: C1 esterase inhibitor in pediatric cardiac surgery with cardiopulmonary bypass plays a vital role in activation of the complement system

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About: C1 esterase inhibitor in pediatric cardiac surgery with cardiopulmonary bypass plays a vital role in activation of the complement system Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	C1 esterase inhibitor in pediatric cardiac surgery with cardiopulmonary bypass plays a vital role in activation of the complement system
Creator	Yamada, Yoshiyuki Miyamoto, Takashi Ozaki, Shinichi Tanaka, Yuki Inui, · Matsumoto, ·
Source	PMC
abstract	Our prospective study was therefore designed to determine which part of the systemic inflammatory response after cardiac operations resulted from Cardiopulmonary bypass (CPB) in neonates and infants. After approval by the human ethical committee of the Gunma Children’s Medical Center (GCMC) and informed consent of the parents, 40 consecutive term congenital heart disease patients aged until 1 year who underwent long CPB time (> 3 h) at surgery were included in the prospective study between January 2012 and December 2014. C1 esterase inhibitor (C1-inh) drug (@Berinert) was generously provided by CSL Behring (King of Prussia, PA). The C1-inh (20 IU/kg) was given intravenously 60 min after CPB. Blood samples for complement factors were obtained before and 48 h after administration of C1-inh. Six patients did not survive and their data were not included. Of 34 patients included, median age was 6.5 months, median body weight was 6050 g, and 16 (47%) were female. According to the Mann–Whitney U test, there were no differences between the two groups concerning demographic and intraoperative data, postoperative chemical data. C1q concentration was only significant lower in patients with C1-inh non-treated group than in patients with C1-inh treated group. But, the consumption of C1q, C3, C4, CH(50), and C1-inh in patients with C1-inhibitor non-treated group was observed early postoperatively. There is a significant difference in the values before and after C1-inh treatment between the two groups. The lower value in the C1-inh-treated group is explained by the activation of the classical pathway through the replenishment of complements by C1-inh treatment. This study proposes the administration of C1-inh is an effective therapy to reduce the activation and improve the clinical capillary leak syndrome.
has issue date	2019-07-05(xsd:dateTime)
bibo:doi	10.1007/s00380-019-01466-2
bibo:pmid	31278424
has license	no-cc
sha1sum (hex)	a07819f279cf7c777e717339c3aef1ce509f8c07
schema:url	https://doi.org/10.1007/s00380-019-01466-2
resource representing a document's title	C1 esterase inhibitor in pediatric cardiac surgery with cardiopulmonary bypass plays a vital role in activation of the complement system
has PubMed Central identifier	PMC7223185
has PubMed identifier	31278424
schema:publication	Heart Vessels
resource representing a document's body	covid:a07819f279cf7c777e717339c3aef1ce509f8c07#body_text
is schema:about of	named entity 'values' named entity 'C1-inh' named entity 'C1-inh' named entity 'CPB' named entity 'C1-inhibitor' named entity 'C1-inh' named entity 'pediatric' named entity 'C1 esterase inhibitor' named entity 'complement system' named entity 'VALUE' named entity 'GIVEN' named entity 'MIN' named entity 'FEMALE' named entity 'Prussia' named entity 'patients' named entity 'data' named entity 'According' named entity 'patients' named entity 'C1-inh' named entity 'systemic' named entity 'membrane attack complex' named entity 'cardiac surgeon' named entity 'blood samples' named entity 'body weight' named entity 'C1-inhibitor' named entity 'C1q' named entity 'body weight' named entity 'This' named entity 'time' named entity 'informed consent' named entity 'Cardiopulmonary bypass' named entity 'Blood samples' named entity 'C1-inh' named entity 'C1 esterase inhibitor' named entity 'systemic inflammatory response' named entity 'C1-inh' named entity 'median age' named entity 'prospective study' named entity 'C1q' named entity 'complement factors' named entity 'complement' named entity 'nitroglycerin' named entity 'inotropic' named entity 'single center' named entity 'diazepam' named entity 'C1-inh' named entity 'cardioplegia' named entity 'arterial catheter' named entity 'active sites' named entity 'ethacrynic acid' named entity 'systemic inflammatory response' named entity 'generalized edema' named entity 'diuresis' named entity 'lungs' named entity 'intravenously' named entity 'body temperature' named entity 'body weight' named entity 'open-heart operation' named entity 'congenital' named entity 'cardiopulmonary bypass' named entity 'endothelial cell' named entity 'C5a' named entity 'CLS' named entity 'neonates' named entity 'perfusion' named entity 'intensive care unit' named entity 'anesthesia' named entity 'bradykinin' named entity 'intrinsic pathway' named entity 'complement activation' named entity 'Perioperative' named entity 'C1-INH' named entity 'Hereditary Angioedema' named entity 'anesthetic' named entity 'nasotracheal intubation' named entity 'C1-inh'

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