About: Bovine Neonatal Pancytopenia is a heritable trait of the dam rather than the calf and correlates with the magnitude of vaccine induced maternal alloantibodies not the MHC haplotype

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About: Bovine Neonatal Pancytopenia is a heritable trait of the dam rather than the calf and correlates with the magnitude of vaccine induced maternal alloantibodies not the MHC haplotype Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bovine Neonatal Pancytopenia is a heritable trait of the dam rather than the calf and correlates with the magnitude of vaccine induced maternal alloantibodies not the MHC haplotype
Creator	Nielen, Mirjam Van Schaik, Gerdien Rutten, Victor Benedictus, Lindert Koets, Ad Otten, Henny Cm Heuven, Henri Gj Van Ginkel, Walter
Source	Medline; PMC
abstract	Bovine Neonatal Pancytopenia (BNP), a bleeding syndrome of neonatal calves, is caused by alloantibodies absorbed from the colostrum of particular cows. A commercial BVD vaccine is the likely source of alloantigens eliciting BNP associated alloantibodies. We hypothesized that the rare occurrence of BNP in calves born to vaccinated dams could be associated with genetic differences within dams and calves. We found that the development of BNP within calves was a heritable trait for dams, not for calves and had a high heritability of 19%. To elucidate which genes play a role in the development of BNP we sequenced candidate genes and characterized BNP alloantibodies. Alloantigens present in the vaccine have to be presented to the dam’s immune system via MHC class II, however sequencing of DRB3 showed no differences in MHC class II haplotype between BNP and non-BNP dams. MHC class I, a highly polymorphic alloantigen, is an important target of BNP alloantibodies. Using a novel sequence based MHC class I typing method, we found no association of BNP with MHC class I haplotype distribution in dams or calves. Alloantibodies were detected in both vaccinated BNP and non-BNP dams and we found no differences in alloantibody characteristics between these groups, but alloantibody levels were significantly higher in BNP dams. We concluded that the development of BNP in calves is a heritable trait of the dam rather than the calf and genetic differences between BNP and non-BNP dams are likely due to genes controlling the quantitative alloantibody response following vaccination. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13567-014-0129-0) contains supplementary material, which is available to authorized users.
has issue date	2014-12-17(xsd:dateTime)
bibo:doi	10.1186/s13567-014-0129-0
bibo:pmid	25516422
has license	cc-by
sha1sum (hex)	a0473481ffa8d1684f3ffadd27a6b9c0583ab35a
schema:url	https://doi.org/10.1186/s13567-014-0129-0
resource representing a document's title	Bovine Neonatal Pancytopenia is a heritable trait of the dam rather than the calf and correlates with the magnitude of vaccine induced maternal alloantibodies not the MHC haplotype
has PubMed Central identifier	PMC4269077
has PubMed identifier	25516422
schema:publication	Vet Res
resource representing a document's body	covid:a0473481ffa8d1684f3ffadd27a6b9c0583ab35a#body_text
is schema:about of	named entity 'dam' named entity 'vaccination' named entity 'typing' named entity 'dams' named entity 'bleeding' named entity 'alloantibodies' named entity 'BUT' named entity 'SEQUENCE BASED' named entity 'SEQUENCING' named entity 'DETECTED' named entity '27S' named entity 'CHARACTERISTICS' named entity 'CAUSED BY' named entity 'PANCYTOPENIA' named entity 'ROLE' named entity 'calves' named entity 'genes' named entity 'calves' named entity 'alloantibody' named entity 'vaccinated' named entity 'MHC class I' named entity 'BVD' named entity 'presented' named entity 'haplotype' named entity 'colostrum' named entity 'alloantibody' named entity 'Pancytopenia' named entity 'alloantibodies' named entity 'alloantibody' named entity 'MHC' named entity 'alloantibodies' named entity 'alloantigen' named entity 'alloantibodies' named entity 'Alloantigens' named entity 'MHC' named entity 'colostrum' named entity 'heritable trait' named entity 'epitope' named entity 'conformation' named entity 'B2M' named entity 'exon' named entity 'intron 1' named entity 'extracellular' named entity 'alleles' named entity 'gene' named entity 'heritability' named entity 'MHC' named entity 'Animal Health' named entity 'Pfizer' named entity 'phenotype' named entity 'statistical test' named entity 'extracellular' named entity 'distilled water' named entity 'FITC' named entity 'colostrum' named entity 'haplotype' named entity 'disease resistance' named entity 'B2M' named entity 'primers' named entity 'MHC' named entity 'allele' named entity 'PBMC' named entity 'effector' named entity 'PBMC' named entity 'alloantigens' named entity 'FDR' named entity 'allogeneic' named entity 'FDR' named entity 'alloantibodies' named entity 'MHC' named entity 'non-self' named entity 'vector' named entity 'allogeneic' named entity 'MHC class II'

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