About: H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens

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About: H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens
Creator	Kida, Hiroshi Sakoda, Yoshihiro Soda, Kosuke Asakura, Shingo Okamatsu, Masatoshi
Source	Medline; PMC
abstract	BACKGROUND: Outbreaks of avian influenza (AI) caused by infection with low pathogenic H9N2 viruses have occurred in poultry, resulting in serious economic losses in Asia and the Middle East. It has been difficult to eradicate the H9N2 virus because of its low pathogenicity, frequently causing in apparent infection. It is important for the control of AI to assess whether the H9N2 virus acquires pathogenicity as H5 and H7 viruses. In the present study, we investigated whether a non-pathogenic H9N2 virus, A/chicken/Yokohama/aq-55/2001 (Y55) (H9N2), acquires pathogenicity in chickens when a pair of di-basic amino acid residues is introduced at the cleavage site of its HA molecule. RESULTS: rgY55sub (H9N2), which had four basic amino acid residues at the HA cleavage site, replicated in MDCK cells in the absence of trypsin after six consecutive passages in the air sacs of chicks, and acquired intravenous pathogenicity to chicken after four additional passages. More than 75% of chickens inoculated intravenously with the passaged virus, rgY55sub-P10 (H9N2), died, indicating that it is pathogenic comparable to that of highly pathogenic avian influenza viruses (HPAIVs) defined by World Organization for Animal Health (OIE). The chickens inoculated with the virus via the intranasal route, however, survived without showing any clinical signs. On the other hand, an avirulent H5N1 strain, A/duck/Hokkaido/Vac-1/2004 (Vac1) (H5N1), acquired intranasal pathogenicity after a pair of di-basic amino acid residues was introduced into the cleavage site of the HA, followed by two passages by air sac inoculation in chicks. CONCLUSION: The present results demonstrate that an H9N2 virus has the potential to acquire intravenous pathogenicity in chickens although the morbidity via the nasal route of infection is lower than that of H5N1 HPAIV.
has issue date	2011-02-10(xsd:dateTime)
bibo:doi	10.1186/1743-422x-8-64
bibo:pmid	21310053
has license	cc-by
sha1sum (hex)	a040109f4ae97738c7940d711a60f07f573b9754
schema:url	https://doi.org/10.1186/1743-422x-8-64
resource representing a document's title	H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens
has PubMed Central identifier	PMC3048564
has PubMed identifier	21310053
schema:publication	Virol J
resource representing a document's body	covid:a040109f4ae97738c7940d711a60f07f573b9754#body_text
is schema:about of	named entity 'INFLUENZA VIRUS' named entity 'SITE OF' named entity 'apparent' named entity 'assess' named entity 'H9N2' named entity 'site' named entity 'CLEAVAGE' named entity 'CHICKENS' named entity 'INTRAVENOUS' named entity 'BASIC AMINO ACID' named entity 'INFECTION' named entity 'MOLECULE' named entity 'HEMAGGLUTININ' named entity 'CONTROL' named entity 'INTRODUCED' named entity 'FREQUENTLY' named entity 'PAIR' named entity 'ASSESS' named entity 'OUTBREAKS' named entity 'INTRODUCTION' named entity 'PATHOGENICITY' named entity 'CONSECUTIVE' named entity 'PATHOGENIC' named entity 'HAVE' named entity 'CLEAVAGE' named entity 'RESULTING IN' named entity 'NON-' named entity 'BACKGROUND' named entity 'MIDDLE EAST' named entity 'APPARENT' named entity 'PRESENT' named entity 'LOW' named entity 'CAUSED BY' named entity 'VIRUSES' named entity 'POULTRY' named entity 'ITS' named entity 'SITE OF' named entity 'STUDY' named entity 'DIFFICULT' named entity 'ASIA' named entity 'AVIAN INFLUENZA' named entity 'H9N2 VIRUS' named entity 'OCCURRED' named entity 'PATHOGENICITY' named entity 'BASIC AMINO ACID' named entity 'CHICKENS' named entity 'PAIR' named entity 'CAUSING' named entity 'IMPORTANT' named entity 'INVESTIGATED' named entity 'ECONOMIC' named entity 'Asia' named entity 'investigated' named entity 'chickens' named entity 'viruses' named entity 'acid' named entity 'control' named entity '2001' named entity 'infection' named entity 'virus' named entity 'H9N2' named entity 'pathogenicity' named entity 'H9N2' named entity 'Middle East' named entity 'avian influenza' named entity 'infection' named entity 'pathogenicity' named entity 'intravenous' named entity 'amino acid residues' named entity 'pathogenicity' named entity 'H9N2' named entity 'blood samples' named entity 'H5N1' named entity 'embryos' named entity 'pathogenicity' named entity 'Viral titers' named entity 'H5N1'

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