About: Outcomes and Spectrum of Major Neurovascular Events Among COVID-19 Patients: A 3-Center Experience

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Outcomes and Spectrum of Major Neurovascular Events Among COVID-19 Patients: A 3-Center Experience
Creator	Gupta, Gaurav Nanda, Anil Cheng, Roger Johnson, Stephen Khandelwal, Priyank Lee, Kiwon Patel, Purvee Rallo, Michael Roychowdhury, Sudipta Singla, Amit Smith, Lindsey Sun, Hai Taylor, Blake
Source	PMC
abstract	BACKGROUND: Preliminary data suggest that Coronavirus Disease-2019 (COVID-19) is associated with hypercoagulability and neurovascular events, but data on outcomes is limited. OBJECTIVE: To report the clinical course and outcomes of a case series of COVID-19 patients with a variety of cerebrovascular events. METHODS: We performed a multicentric, retrospective chart review at our three academic tertiary care hospitals, and identified all COVID-19 patients with cerebrovascular events requiring neuro-intensive care and/or neurosurgical consultation. RESULTS: We identified 26 patients between March 1 and May 24, 2020, of whom 12 (46%) died. The most common event was a large-vessel occlusion (LVO) in 15 patients (58%), among whom 8 died (8/15, 53%). A total of 9 LVO patients underwent mechanical thrombectomy, of whom 5 died (5/9, 56%). A total of 7 patients (27%) presented with intracranial hemorrhage. Of the remaining patients, 2 had small-vessel occlusions, 1 had cerebral venous sinus thrombosis, and another had a vertebral artery dissection. Acute Respiratory Distress Syndrome occurred in 8 patients, of whom 7 died. Mortalities had a higher D-dimer on admission (mean 20 963 ng/mL) than survivors (mean 3172 ng/mL). Admission Glasgow Coma Scale (GCS) score was poor among mortalities (median 7), whereas survivors had a favorable GCS at presentation (median 14) and at discharge (median 14). CONCLUSION: COVID-19 may be associated with hemorrhage as well as ischemia, and prognosis appears poorer than expected—particularly among LVO cases, where outcome remained poor despite mechanical thrombectomy. However, a favorable neurological condition on admission and lower D-dimer may indicate a better outcome.
has issue date	2020-07-17(xsd:dateTime)
bibo:doi	10.1093/neuopn/okaa008
has license	cc-by-nc
schema:url	https://doi.org/10.1093/neuopn/okaa008
resource representing a document's title	Outcomes and Spectrum of Major Neurovascular Events Among COVID-19 Patients: A 3-Center Experience
has PubMed Central identifier	PMC7454798
resource representing a document's body	covid:PMC7454798#body_text
is schema:about of	named entity 'COVID-19' named entity 'Outcomes' named entity 'intracranial hemorrhage' named entity 'craniectomy' named entity 'cerebral venous sinus thrombosis' named entity 'hemorrhage' named entity 'neurological condition' named entity 'vasculitis' named entity 'hemorrhage' named entity 'vasospasm' named entity 'COVID' named entity 'mechanical thrombectomy' named entity 'case fatality rate' named entity 'COVID-19' named entity 'anticoagulation' named entity 'LVO' named entity 'initial condition' named entity 'LVO' named entity 'hemorrhage' named entity 'mortality rate' named entity 'vascular endothelial' named entity 'ischemia' named entity 'Glasgow Coma Scale' named entity 'coronavirus' named entity 'thrombogenic' named entity 'LVO' named entity 'acute subdural hematoma' named entity 'demographic' named entity 'COVID' named entity 'hemorrhage' named entity 'hypertensive' named entity 'cytokine' named entity 'ischemia' named entity 'Disseminated Intravascular Coagulation' named entity 'GCS' named entity 'mortality rate' named entity 'venous thrombosis' named entity 'GCS' named entity 'intensive care' named entity 'intensivists' named entity 'metastasis' named entity 'neurosurgeons' named entity 'prognosis' named entity 'VTE' named entity 'vessel occlusion' named entity 'D-dimer' named entity 'case series' named entity 'neurosurgical' named entity 'neurological' named entity 'COVID-19' named entity 'organ systems' named entity 'ARDS' named entity 'vertebral artery dissection' named entity 'nasopharyngeal swab' named entity 'pituitary adenoma' named entity 'LVO' named entity 'subarachnoid hemorrhage' named entity 'cerebrovascular' named entity 'tertiary care' named entity 'endothelial dysfunction' named entity 'risk factors' named entity 'intensive care unit' named entity 'neurological' named entity 'angiotensin-converting enzyme 2' named entity 'aneurysm' named entity 'arterial dissection' named entity 'fulminant' named entity 'risk factors' named entity 'SDH' named entity 'mechanical thrombectomy' named entity 'malignant' named entity 'pathology' named entity 'decompressive craniectomy'

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