About: Potential Influence of Menstrual Status and Sex Hormones on Female Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Cross-sectional Multicenter Study in Wuhan, China

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About: Potential Influence of Menstrual Status and Sex Hormones on Female Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Cross-sectional Multicenter Study in Wuhan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Potential Influence of Menstrual Status and Sex Hormones on Female Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Cross-sectional Multicenter Study in Wuhan, China
Creator	Wang, Bo Wang, Tian Miao, Xiaoping Chen, Zhe Jiang, Jingjing Cui, Pengfei Dai, Jun Chang, Jiang Ding, Ting Ma, Wenqing Ma, Xiangyi Rong, Yueguang Wang, Shixuan Yuan, Suzhen Zhang, Jinjin Zhou, Su Ma, Lingwei
Source	Medline; PMC
abstract	BACKGROUND: Recent studies have indicated that females with coronavirus disease 2019 (COVID-19) have a lower morbidity, severe case rate, and mortality and better outcome than those of male individuals. However, the reasons remained to be addressed. METHODS: To find the factors that potentially protect females from COVID-19, we recruited all confirmed patients hospitalized at 3 branches of Tongji Hospital (N = 1902), and analyzed the correlation between menstrual status (n = 509, including 68 from Mobile Cabin Hospital), female hormones (n = 78), and cytokines related to immunity and inflammation (n = 263), and the severity/clinical outcomes in female patients <60 years of age. RESULTS: Nonmenopausal female patients had milder severity and better outcome compared with age-matched men (P < .01 for both). Menopausal patients had longer hospitalization times than nonmenopausal patients (hazard ratio [HR], 1.91 [95% confidence interval {CI}, 1.06–3.46]; P = .033). Both anti-Müllerian hormone (AMH) and estradiol (E2) showed a negative correlation with severity of infection (adjusted HR, 0.146 [95% CI, .026–.824], P = .029 and 0.304 [95% CI, .092–1.001], P = .05, respectively). E2 levels were negatively correlated with interleukin (IL) 2R, IL-6, IL-8, and tumor necrosis factor alpha in the luteal phase (P = .033, P = .048, P = .054, and P = .023) and C3 in the follicular phase (P = .030). CONCLUSIONS: Menopause is an independent risk factor for female COVID-19 patients. AMH and E2 are potential protective factors, negatively correlated with COVID-19 severity, among which E2 is attributed to its regulation of cytokines related to immunity and inflammation.
has issue date	2020-07-22(xsd:dateTime)
bibo:doi	10.1093/cid/ciaa1022
bibo:pmid	32697835
has license	no-cc
schema:url	https://doi.org/10.1093/cid/ciaa1022
resource representing a document's title	Potential Influence of Menstrual Status and Sex Hormones on Female Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Cross-sectional Multicenter Study in Wuhan, China
has PubMed Central identifier	PMC7454316
has PubMed identifier	32697835
schema:publication	Clin Infect Dis
resource representing a document's body	covid:PMC7454316#body_text
is schema:about of	named entity 'regression analysis' named entity 'hormone' named entity 'clinical outcomes' named entity 'hormonal' named entity 'chemokines' named entity 'AMH' named entity 'correlation' named entity 'estrogen' named entity 'SARS' named entity '95% confidence interval' named entity 'tumor necrosis factor alpha' named entity 'cytokines' named entity 'anti-Müllerian hormone' named entity 'causal relationship' named entity 'viral infection' named entity 'luteal phase' named entity 'viral infections' named entity 'logistic regression' named entity 'hormone therapy' named entity 'flowchart' named entity 'negatively correlated' named entity 'inflammation' named entity 'immune response' named entity 'Huazhong University of Science and Technology' named entity 'COVID-19' named entity 'SARS-CoV-2' named entity 'Wuhan' named entity 'female hormones' named entity 'hazard ratio' named entity 'IL6' named entity 'lymphoid cells' named entity 'X-linked' named entity 'coefficients of variation' named entity 'immunoproteins' named entity 'AMH' named entity 'Severe Acute Respiratory Syndrome Coronavirus 2' named entity 'Potential' named entity 'Cross-sectional' named entity 'Wuhan' named entity 'female hormones' named entity 'probability' named entity 'comorbidities' named entity 'cytokines' named entity 'SARS-CoV-2' named entity 'AMH' named entity 'viral infection' named entity '23.5%' named entity 'clinical outcomes' named entity 'Serum' named entity 'comorbidities' named entity 'pregnancy' named entity 'immune response' named entity '0.01' named entity 'menstruation' named entity 'positively correlated' named entity 'interleukin' named entity 'serum' named entity 'inflammation' named entity 'adverse reactions' named entity 'menopause' named entity 'humoral immune responses' named entity 'sex hormones' named entity 'IL-10' named entity 'luteal phase' named entity 'IL-10' named entity 'Tongji Hospital'

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