About: Obesity and Smoking as Risk Factors for Invasive Mechanical Ventilation in COVID-19 Respiratory Failure: a Retrospective, Observational Cohort Study

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About: Obesity and Smoking as Risk Factors for Invasive Mechanical Ventilation in COVID-19 Respiratory Failure: a Retrospective, Observational Cohort Study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Obesity and Smoking as Risk Factors for Invasive Mechanical Ventilation in COVID-19 Respiratory Failure: a Retrospective, Observational Cohort Study
Creator	Sapru, Anil Monteiro, Ana Qadir, Nida Wang, Tisha Goodman-Meza, David Fulcher, Jennifer Buhr, Russell Chang, Steven Cortes-Lopez, Roxana Emeruwa, Iheanacho Lindsay, Catherine Sherman, Alexander Stretch, Robert Suri, Rajat
Source	MedRxiv; Medline; PMC
abstract	PURPOSE: To describe the trajectory of respiratory failure in COVID-19 and explore factors associated with risk of invasive mechanical ventilation (IMV). MATERIALS AND METHODS: A retrospective, observational cohort study of 112 inpatient adults diagnosed with COVID-19 between March 12 and April 16, 2020. Data were manually extracted from electronic medical records. Multivariable and Univariable regression were used to evaluate association between baseline characteristics, initial serum markers and the outcome of IMV. RESULTS: Our cohort had median age of 61 (IQR 45–74) and was 66% male. In-hospital mortality was 6% (7/112). ICU mortality was 12.8% (6/47), and 18% (5/28) for those requiring IMV. Obesity (OR 5.82, CI 1.74–19.48), former (OR 8.06, CI 1.51–43.06) and current smoking status (OR 10.33, CI 1.43–74.67) were associated with IMV after adjusting for age, sex, and high prevalence comorbidities by multivariable analysis. Initial absolute lymphocyte count (OR 0.33, CI 0.11–0.96), procalcitonin (OR 1.27, CI 1.02–1.57), IL-6 (OR 1.17, CI 1.03–1.33), ferritin (OR 1.05, CI 1.005–1.11), LDH (OR 1.57, 95% CI 1.13–2.17) and CRP (OR 1.13, CI 1.06–1.21), were associated with IMV by univariate analysis. CONCLUSIONS: Obesity, smoking history, and elevated inflammatory markers were associated with increased need for IMV in patients with COVID-19.
has issue date	2020-08-14(xsd:dateTime)
bibo:doi	10.1101/2020.08.12.20173849
bibo:pmid	32817959
has license	cc-by-nc-nd
schema:url	https://doi.org/10.1101/2020.08.12.20173849
resource representing a document's title	Obesity and Smoking as Risk Factors for Invasive Mechanical Ventilation in COVID-19 Respiratory Failure: a Retrospective, Observational Cohort Study
has PubMed Central identifier	PMC7430603
has PubMed identifier	32817959
schema:publication	medRxiv
resource representing a document's body	covid:PMC7430603#body_text
is schema:about of	named entity 'Study' named entity 'mg/dl' named entity 'ventilator' named entity 'mechanical ventilation' named entity 'extracorporeal' named entity 'invasive mechanical ventilation' named entity 'PEEP' named entity 'infection' named entity 'VTE' named entity 'remdesivir' named entity 'ARDS' named entity 'patient outcomes' named entity 'respiratory failure' named entity 'thrombi' named entity 'ICU' named entity 'deep venous thrombosis' named entity 'tested positive for COVID-19' named entity 'COVID' named entity 'COVID' named entity 'cmH2O' named entity 'ARDS' named entity 'high-altitude pulmonary edema' named entity 'biomarkers' named entity 'placebo-controlled trial' named entity 'etiologies' named entity 'vasculature' named entity 'tocilizumab' named entity 'ACE-inhibitors' named entity 'intubation' named entity 'LDH' named entity 'lung' named entity 'body mass index' named entity 'body weight' named entity 'pandemic response team' named entity 'deep venous thrombosis' named entity 'acute respiratory distress syndrome' named entity 'VTE' named entity 'University of California, Los Angeles' named entity 'comorbidity' named entity 'respiratory failure' named entity 'hydroxychloroquine' named entity 'absolute lymphocyte count' named entity 'Failure' named entity 'Risk Factors' named entity 'Invasive Mechanical Ventilation' named entity 'Respiratory Failure' named entity 'Cohort Study' named entity 'ischemic' named entity 'SARS-CoV-2' named entity 'D-dimer' named entity 'COVID' named entity 'bronchoalveolar lavage' named entity 'physical and occupational therapy' named entity 'sedation' named entity 'hemoglobin' named entity 'therapeutic targets' named entity 'respiratory failure' named entity 'anticoagulation' named entity 'chronic conditions' named entity 'extracorporeal membrane oxygenation' named entity '14/28' named entity 'Los Angeles County' named entity 'ARDS' named entity 'hypercapnic' named entity 'ARDS' named entity 'macrophage' named entity 'steroids' named entity 'SARS-CoV-2' named entity 'BMI'

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