About: Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data

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About: Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data
Creator	Mouthon, Luc Kerneis, Solen Lescure, François-Xavier Morbieu, Caroline Pawlotsky, Jean-Michel Audureau, Etienne Carlier, Nicolas Matignon, Marie Ravaud, Philippe Roche, Nicolas Schlemmer, Frédéric Szwebel, Tali-Anne Terrier, Benjamin Tran, Viet-Thi Crickx, Etienne Dang, Julien Godeau, Bertrand Legendre, Paul Mahévas, Matthieu Michel, Marc Chabrol, Amélie Costedoat-Chalumeau, Nathalie Fois, Elena Gallien, Sébastien Guillaud, Constance Khellaf, Mehdi Lepeule, Raphael Ménager, Philippe Ourghanlian, Clément Paule, Romain Perrodeau, Elodie Roumier, Mathilde Schoindre, Yoland de Lastours, Victoire
Source	Medline; PMC
abstract	OBJECTIVE: To assess the effectiveness of hydroxychloroquine in patients admitted to hospital with coronavirus disease 2019 (covid-19) pneumonia who require oxygen. DESIGN: Comparative observational study using data collected from routine care. SETTING: Four French tertiary care centres providing care to patients with covid-19 pneumonia between 12 March and 31 March 2020. PARTICIPANTS: 181 patients aged 18-80 years with documented severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia who required oxygen but not intensive care. INTERVENTIONS: Hydroxychloroquine at a dose of 600 mg/day within 48 hours of admission to hospital (treatment group) versus standard care without hydroxychloroquine (control group). MAIN OUTCOME MEASURES: The primary outcome was survival without transfer to the intensive care unit at day 21. Secondary outcomes were overall survival, survival without acute respiratory distress syndrome, weaning from oxygen, and discharge from hospital to home or rehabilitation (all at day 21). Analyses were adjusted for confounding factors by inverse probability of treatment weighting. RESULTS: In the main analysis, 84 patients who received hydroxychloroquine within 48 hours of admission to hospital (treatment group) were compared with 89 patients who did not receive hydroxychloroquine (control group). Eight additional patients received hydroxychloroquine more than 48 hours after admission. In the weighted analyses, the survival rate without transfer to the intensive care unit at day 21 was 76% in the treatment group and 75% in the control group (weighted hazard ratio 0.9, 95% confidence interval 0.4 to 2.1). Overall survival at day 21 was 89% in the treatment group and 91% in the control group (1.2, 0.4 to 3.3). Survival without acute respiratory distress syndrome at day 21 was 69% in the treatment group compared with 74% in the control group (1.3, 0.7 to 2.6). At day 21, 82% of patients in the treatment group had been weaned from oxygen compared with 76% in the control group (weighted risk ratio 1.1, 95% confidence interval 0.9 to 1.3). Eight patients in the treatment group (10%) experienced electrocardiographic modifications that required discontinuation of treatment. CONCLUSIONS: Hydroxychloroquine has received worldwide attention as a potential treatment for covid-19 because of positive results from small studies. However, the results of this study do not support its use in patients admitted to hospital with covid-19 who require oxygen.
has issue date	2020-05-14(xsd:dateTime)
bibo:doi	10.1136/bmj.m1844
bibo:pmid	32409486
has license	cc-by-nc
schema:url	https://doi.org/10.1136/bmj.m1844
resource representing a document's title	Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data
has PubMed Central identifier	PMC7221472
has PubMed identifier	32409486
schema:publication	BMJ
resource representing a document's body	covid:PMC7221472#body_text
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