About: HijAkt: The PI3K/Akt Pathway in Virus Replication and Pathogenesis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	HijAkt: The PI3K/Akt Pathway in Virus Replication and Pathogenesis
Creator	Connor, John Dunn, Ewan
Source	PMC
abstract	As obligate parasites of cellular processes, viruses must take over cellular macromolecular machinery. It is also becoming clear that viruses routinely control intracellular signaling pathways through the direct or indirect control of kinases and phosphatases. This control of cellular phosphoproteins is important to promote a variety of viral processes, from control of entry to nuclear function to the stimulation of viral protein synthesis. This review focuses on the takeover of the cellular phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway by a variety of retroviruses, DNA viruses, and RNA viruses, highlighting the functions ascribed to virus activation of PI3K and Akt activity. This review also describes the role that the PI3K/Akt pathway plays in the host response, noting that it that can trigger anti- as well as proviral functions.
has issue date	2012-02-13(xsd:dateTime)
bibo:doi	10.1016/b978-0-12-396456-4.00002-x
bibo:pmid	22340720
has license	no-cc
schema:url	https://doi.org/10.1016/b978-0-12-396456-4.00002-x
resource representing a document's title	HijAkt: The PI3K/Akt Pathway in Virus Replication and Pathogenesis
has PubMed Central identifier	PMC7149925
has PubMed identifier	22340720
schema:publication	Prog Mol Biol Transl Sci
resource representing a document's body	covid:PMC7149925#body_text
is schema:about of	named entity 'apoptosis' named entity 'kinase' named entity 'Akt' named entity 'PI3K/Akt' named entity 'phosphorylation' named entity 'PI3K' named entity 'long-term' named entity 'viral nonstructural protein' named entity 'tyrosine kinase' named entity 'Akt' named entity 'PIP3' named entity 'RTK' named entity 'TSC1' named entity 'EBV' named entity 'viruses' named entity 'kinases' named entity 'Akt signaling pathway' named entity 'viruses' named entity 'akt' named entity 'PI3K' named entity 'autonomous growth' named entity 'respiratory syncytial virus' named entity 'transcription factors' named entity 'Akt' named entity 'signaling cascade' named entity 'viruses' named entity 'TSC2' named entity 'viruses' named entity 'GSK3' named entity 'transcription' named entity 'phosphorylation' named entity 'Akt' named entity 'LMP1' named entity 'tuberin' named entity 'intracellular' named entity 'virus particle' named entity 'virus replication' named entity 'cytokine' named entity 'Akt' named entity 'PI3K/Akt pathway' named entity 'gag protein' named entity 'apoptotic' named entity 'substrates' named entity 'nonstructural protein' named entity 'phosphoprotein' named entity 'chikungunya' named entity 'RVFV' named entity 'viruses' named entity 'virus infection' named entity 'Akt' named entity 'viruses' named entity 'Akt signaling pathway' named entity 'DNA damage repair' named entity 'PI3K/Akt' named entity 'PI3K/Akt' named entity 'receptor' named entity 'infection' named entity 'PI3K/Akt' named entity 'assembly and budding' named entity 'life cycle' named entity 'PI3K/Akt pathway' named entity 'phosphorylating' named entity 'HPV' named entity 'homolog' named entity 'phosphorylation' named entity 'kinase' named entity 'VSV' named entity 'viruses' named entity 'growth factor' named entity 'myxoma' named entity 'SV40' named entity 'Akt' named entity 'chronic diseases' named entity 'RNA' named entity 'kinase' named entity 'pediatric' named entity 'Burkitt lymphoma/leukemia' named entity 'Akt' named entity 'short-term' named entity 'threonine' named entity 'measles'

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