About: Polymerases of Coronaviruses: Structure, Function, and Inhibitors

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Polymerases of Coronaviruses: Structure, Function, and Inhibitors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Polymerases of Coronaviruses: Structure, Function, and Inhibitors
Creator	Al-Nema, Mayasah Gaurav, Anand Gupta, Satya
Source	PMC
abstract	Coronaviruses (CoVs) are a major group of viruses known to be responsible for wide spectrum of diseases in multiple species. The CoVs affecting human population are referred to as human coronaviruses (HCoVs). They lead to multiple respiratory diseases, such as common cold, pneumonia, bronchitis, severe acute respiratory syndrome, and Middle East respiratory syndrome. CoVs are RNA viruses that require RNA-dependent RNA polymerases (RdRPs) for various steps in their life cycle. Action of RdRP is needed in several steps in the life cycle of CoVs and thus RdRPs constitute potential targets for drugs and other therapeutic interventions for the treatment of diseases caused by CoVs. The chapter therefore presents a detailed discussion on the structure and functions of CoV polymerases and the development of their potential inhibitors.
has issue date	2018-11-02(xsd:dateTime)
bibo:doi	10.1016/b978-0-12-815422-9.00010-3
has license	no-cc
schema:url	https://doi.org/10.1016/b978-0-12-815422-9.00010-3
resource representing a document's title	Polymerases of Coronaviruses: Structure, Function, and Inhibitors
has PubMed Central identifier	PMC7149517
schema:publication	Viral Polymerases
resource representing a document's body	covid:PMC7149517#body_text
is schema:about of	named entity 'aspartates' named entity 'SARS-CoV' named entity 'RNA synthesis' named entity 'RNA' named entity 'protein' named entity 'SARS-CoV' named entity 'polymerase' named entity 'RNA-dependent DNA polymerase' named entity 'short hairpin RNA' named entity 'RdRP' named entity 'critical role' named entity 'site-directed mutagenesis' named entity 'hydrogen bonds' named entity 'oligonucleotide' named entity 'viruses' named entity 'antivirals' named entity 'gene' named entity 'serine protease' named entity 'siRNA' named entity 'RNA genome' named entity 'RdRP' named entity 'antivirals' named entity 'micromolar' named entity 'replicase' named entity 'mRNA transcripts' named entity 'viral envelope' named entity 'viruses' named entity 'RdRP' named entity 'virus' named entity 'viral replication' named entity 'polymerase' named entity 'human immunodeficiency virus' named entity 'SARS-CoV' named entity 'PDB' named entity 'nonstructural proteins' named entity 'protein' named entity 'RdRP' named entity 'RdRP' named entity 'antiviral' named entity 'conserved residues' named entity 'CoV' named entity 'RdRp' named entity 'CoV' named entity 'HBV' named entity 'RNA' named entity 'polyprotein' named entity 'SARS-CoV' named entity 'respiratory failure' named entity 'viruses' named entity 'SARS-CoV' named entity 'remdesivir' named entity 'RNA viruses' named entity 'minus-strand' named entity 'α-helix' named entity 'ribonucleoside' named entity 'viruses' named entity 'polypeptide' named entity 'Coronavirinae' named entity 'RNA viruses' named entity 'protein-protein interactions' named entity 'crystal structure' named entity 'drug discovery' named entity 'viral polymerase' named entity '10.3' named entity 'genomic replication' named entity 'processivity' named entity 'virus' named entity 'RNA polymerase' named entity 'SARS-CoV' named entity 'cytoplasm' named entity 'enzyme' named entity 'airway' named entity 'antiviral agents' named entity 'molecular model' named entity 'RdRP' named entity 'nucleic acid' named entity 'β-sheet' named entity 'polymerase' named entity 'purines' named entity 'RNA' named entity 'gene' named entity 'protein'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software