About: Plant-based vaccines: unique advantages

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About: Plant-based vaccines: unique advantages Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Plant-based vaccines: unique advantages
Creator	Tizard, Ian Howard, John Bailey, Michele Beifuss, Katherine Delaney, Donna Hood, Elizabeth Horn, Michael Jilka, Joseph Mayor, Jocelyne Streatfield, Stephen Turner, Debra Woodard, Susan
Source	PMC
abstract	Numerous studies have shown that viral epitopes and subunits of bacterial toxins can be expressed and correctly processed in transgenic plants. The recombinant proteins induce immune responses and have several benefits over current vaccine technologies, including increased safety, economy, stability, versatility and efficacy. Antigens expressed in corn are particularly advantageous since the seed can be produced in vast quantities and shipped over long distances at ambient temperature, potentially allowing global vaccination. We have expressed the B-subunit of Escherichia coli heat-labile enterotoxin and the spike protein of swine transmissible gastroenteritis virus at high levels in corn, and demonstrate that these antigens delivered in the seed elicit protective immune responses.
has issue date	2001-03-21(xsd:dateTime)
bibo:doi	10.1016/s0264-410x(00)00512-0
bibo:pmid	11257418
has license	no-cc
schema:url	https://doi.org/10.1016/s0264-410x%2800%2900512-0
resource representing a document's title	Plant-based vaccines: unique advantages
has PubMed Central identifier	PMC7127671
has PubMed identifier	11257418
schema:publication	Vaccine
resource representing a document's body	covid:PMC7127671#body_text
is schema:about of	named entity 'immune response' named entity 'clinical symptoms' named entity 'titer' named entity 'serum' named entity 'corn' named entity '37°C' named entity 'transgenic' named entity '37°C' named entity 'seed' named entity 'mice' named entity 'immune responses' named entity 'infect plants' named entity 'protein stability' named entity 'clinical symptoms' named entity 'biotinylated' named entity 'adverse reaction' named entity 'transgenic plants' named entity 'randomly selected' named entity 'causal agent' named entity 'solid matter' named entity 'vaccine' named entity 'watery diarrhea' named entity 'high levels' named entity 'Protein' named entity 'FIPV' named entity 'immunogenicity' named entity 'GenBank' named entity 'transgenic' named entity 'embryos' named entity 'corn' named entity 'seed' named entity 'BSA' named entity 'bicarbonate' named entity 'protein' named entity 'fecal pellets' named entity 'A. tumefaciens' named entity 'vaccine' named entity 'intestine' named entity 'IgA' named entity 'receptor sites' named entity 'corn' named entity 'Agrobacterium tumefaciens' named entity '37°C' named entity 'vaccine' named entity 'protein' named entity 'general health' named entity 'A. tumefaciens' named entity 'mice' named entity 'PBS' named entity 'piglet' named entity 'corn' named entity 'wild type' named entity 'enterotoxigenic' named entity 'BALB/c' named entity 'somatic' named entity 'PBS buffer' named entity 'mice' named entity 'morbidity' named entity 'corn' named entity 'viral replication' named entity 'backcrossed' named entity 'seed' named entity 'animal pathogens' named entity 'corn' named entity 'zygotic' named entity 'antigen' named entity 'patent' named entity 'virulent' named entity 'food crops' named entity 'supernatant' named entity '37°C'

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