About: Direct and label-free influenza virus detection based on multisite binding to sialic acid receptors

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About: Direct and label-free influenza virus detection based on multisite binding to sialic acid receptors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Direct and label-free influenza virus detection based on multisite binding to sialic acid receptors
Creator	Yamaoka, Shoji Goda, Tatsuro Horiguchi, Yukichi Matsumoto, Akira Miyahara, Yuji Takeuchi, Hiroaki
source	Elsevier; Medline; PMC
abstract	A system to discriminate human or avian influenza A remains a highly sought-after tool for prevention of influenza pandemics in humans. Selective binding of the influenza A viral hemagglutinin (HA) to specific sialic acid (SA) receptors (Neu5Acα(2-6)Gal in humans, Neu5Acα(2-3)Gal in birds) is determined by the genotype of the HA and neuraminidase (NA) segments, making it one of the key characteristics that distinguishes human or avian influenza A virus. Here we demonstrate the direct detection of whole H1N1 influenza A virus using 6′-sialyllactose (Neu5Acα(2-6)Galβ(1-4)Glc, 6SL)-immobilized gold electrodes as biosensing surfaces. The sensitivity was higher than that of conventional immunochromatographic technique (ICT) for influenza virus and not restricted by genetic drift. The label-free detection technology via direct attachment of a whole virus using a chemically modified electrode is a promising means to provide a simple and rapid diagnostic system for viral infections.
has issue date	2017-06-15(xsd:dateTime)
bibo:doi	10.1016/j.bios.2017.02.023
bibo:pmid	28222368
has license	no-cc
schema:url	https://doi.org/10.1016/j.bios.2017.02.023
resource representing a document's title	Direct and label-free influenza virus detection based on multisite binding to sialic acid receptors
has PubMed Central identifier	PMC7127512
has PubMed identifier	28222368
schema:publication	Biosens Bioelectron
resource representing a document's body	covid:PMC7127512#body_text
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