About: Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase

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About: Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase
Creator	Gong, Z.N. Rao, S.Y. Xu, G.L. Yao, L. Yu, S.Q. Zhang, S.Q.
Source	PMC
abstract	Oxymatrine is one of the alkaloids extracted from Chinese herb Sophora japonica (Sophora flavescens Ait.) with activities of anti-inflammation, inhibiting immune reaction, antivirus, protecting hepatocytes and antihepatic fibrosis. However, the effect of oxymatrine on acute lung injury (ALI) has not been known yet. In this study, the effect of oxymatrine on ALI was investigated using an oleic acid-induced ALI mouse model. Morphological findings showed that the oleic acid group demonstrated a marked lung injury represented by prominent atelectasis, intraalveolar and interstitial patchy hemorrhage, edema, thickened alveolar septum, formation of hyaline membranes and the existence of inflammatory cells in alveolar spaces. While in the oxymatrine/dexamethasone group, these changes were less severe and in the vicinity of the control group. Furthermore, pretreatment with oxymatrine significantly alleviated oleic acid-induced lung injury accompanied by reduction of lung index and wet-to-dry weight ratio, decreases in serum TNF-α level and inhibition of phosphorylated p38 MAPK. These findings suggest that oxymatrine has a beneficial effect on acute lung injury induced by oleic acid in mice and may inhibit the production of proinflammatory cytokine, TNF-α, by means of the inhibition of p38 MAPK.
has issue date	2005-04-08(xsd:dateTime)
bibo:doi	10.1016/j.jep.2005.01.026
bibo:pmid	15763380
has license	no-cc
schema:url	https://doi.org/10.1016/j.jep.2005.01.026
resource representing a document's title	Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase
has PubMed Central identifier	PMC7125571
has PubMed identifier	15763380
schema:publication	J Ethnopharmacol
resource representing a document's body	covid:PMC7125571#body_text
is schema:about of	named entity 'inhibition' named entity 'SARS' named entity 'tumor' named entity 'serum' named entity 'oleic acid' named entity 'epithelial' named entity 'intravenous administration' named entity 'ALI' named entity 'hemorrhage' named entity 'p38' named entity 'dexamethasone' named entity 'oleic acid' named entity 'histological examination' named entity 'oxymatrine' named entity 'Light microscopic' named entity 'phosphorylated' named entity 'oxymatrine' named entity 'alveolar spaces' named entity 'lysosome' named entity 'intraperitoneal injection' named entity 'MAP kinase' named entity 'China' named entity 'MAP kinase' named entity 'oleic acid' named entity 'pneumonia' named entity 'Oleic acid' named entity 'oxymatrine' named entity 'p38 MAPK' named entity 'sodium dodecylsulfate' named entity 'oxymatrine' named entity 'sepsis' named entity 'Sophora japonica' named entity 'oxymatrine' named entity 'oxymatrine' named entity 'monocytes' named entity 'left lung' named entity 'p38' named entity 'ALI' named entity 'infectious disease' named entity 'Phosphorylation' named entity 'saline' named entity 'experimental animals' named entity 'MAP kinase' named entity 'mice' named entity 'ischemia reperfusion' named entity 'lung was removed' named entity 'serum' named entity 'ALI' named entity 'Sophora japonica' named entity 'acute lung injury' named entity 'control group' named entity 'oleic acid' named entity 'alveolar spaces' named entity 'oxymatrine' named entity 'standard curve' named entity 'antibodies' named entity 'oxymatrine' named entity 'p38' named entity 'protein' named entity 'lung injury' named entity 'gastric contents' named entity 'protein' named entity 'anti-inflammatory drug' named entity 'ARDS' named entity '0.01' named entity 'control group' named entity 'oxymatrine' named entity 'protein kinase' named entity 'TNF-α' named entity 'oxymatrine' named entity 'Protein' named entity 'ARDS' named entity 'mice' named entity 'thorax' named entity 'oleic acid' named entity 'acute lung injury' named entity 'oxymatrine'

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