About: Functional Consequences Following Infection of the Olfactory System by Intranasal Infusion of the Olfactory Bulb Line Varient (OBLV) of Mouse Hepatitis Strain JHM

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About: Functional Consequences Following Infection of the Olfactory System by Intranasal Infusion of the Olfactory Bulb Line Varient (OBLV) of Mouse Hepatitis Strain JHM Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Functional Consequences Following Infection of the Olfactory System by Intranasal Infusion of the Olfactory Bulb Line Varient (OBLV) of Mouse Hepatitis Strain JHM
Creator	Jubelt, Burk Manglapus, Glen Saha, Sucharita Schwob, James Youngentob, Steven
topic	covid:PMC7110209#this
Source	Medline; PMC
abstract	The present study assessed the functional consequences of viral infection with a neurotropic coronavirus, designated MHV OBLV, that specifically targets central olfactory structures. Using standard operant techniques and a `go, no-go' successive discrimination paradigm, six BALB/c mice were trained to discriminate between the presentation of an air or odor stimulus (three mice for each of the odorants propanol and propyl acetate). Two additional BALB/c mice were trained to discriminate between the presentation of air and the presentation of either vanillin or propionic acid. Following criterion performance, each mouse received an additional 2000 trials of overtraining. At completion of overtraining one mouse from the propanol and propyl acetate groups were allocated as untreated. The remaining six mice were inoculated with 300 μl of the OBLV stock per nostril for a total of 1.5 × 10(6) p.f.u. in 600 μl. Following a 1 month rest, untreated and inoculated animals were again tested on their respective air versus odor discrimination task. Untreated animals immediately performed at criterion levels. In contrast, inoculated animals varied in their capacity to discriminate between air and odorant. Five of the six inoculated mice showed massive disruption of the olfactory bulb, including death of mitral cells; the other was more modestly affected. In addition, the density of innervation of the olfactory mucosa by substance P-containing trigeminal fibers is also affected by inoculation. Those mice that remained anosmic to the training odorants had the most severe reduction in mitral cell number and substance P fiber density among the inoculated animals.
has issue date	2001-10-01(xsd:dateTime)
bibo:doi	10.1093/chemse/26.8.953
bibo:pmid	11595672
has license	no-cc
schema:url	https://doi.org/10.1093/chemse/26.8.953
resource representing a document's title	Functional Consequences Following Infection of the Olfactory System by Intranasal Infusion of the Olfactory Bulb Line Varient (OBLV) of Mouse Hepatitis Strain JHM
has PubMed Central identifier	PMC7110209
has PubMed identifier	11595672
schema:publication	Chem Senses
resource representing a document's body	covid:PMC7110209#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/PMC7110209
is schema:about of	named entity 'Intranasal' named entity 'vanillin' named entity 'methyl bromide' named entity 'mucosa' named entity 'olfactory bulb' named entity 'electrophysiological recordings' named entity 'epithelium' named entity 'viruses' named entity '0.01' named entity 'liver' named entity 'nostril' named entity 'anosmia' named entity 'Intranasal' named entity 'lesion' named entity 'neurons' named entity 'ad libitum' named entity 'inoculation' named entity 'olfactory' named entity 'malaise' named entity 'Virus' named entity 'inoculation' named entity 'Plexiglas' named entity 'inoculation' named entity 'stimulant' named entity 'anesthesia' named entity 'histological analysis' named entity 'chemosensory' named entity 'Biohazard Level' named entity 'inoculation' named entity 'propyl acetate' named entity 'odorants' named entity 'electrophysiological recordings' named entity 'experimental variability' named entity 'muscle tissue' named entity 'Lexington, MA' named entity 'Mitral cells' named entity 'infection' named entity 'complement' named entity 'Fluothane' named entity 'cytopathic' named entity 'smaller than normal' named entity 'inoculation' named entity 'the animals' named entity 'anosmia' named entity 'propyl acetate' named entity 'propyl acetate' named entity 'anosmic' named entity 'viral infection' named entity 'anosmic' named entity 'odorants' named entity 'histological analysis' named entity 'infection' named entity 'vanillin' named entity 'olfactory mucosa' named entity 'zinc sulfate' named entity 'MHV' named entity 'anosmic' named entity 'inoculation' named entity 'epithelium' named entity 'propionic acid' named entity 'catheter' named entity 'MHV' named entity 'zinc sulfate' named entity 'neurotransmitter' named entity 'virus' named entity 'anatomical' named entity 'virus' named entity 'nasal cavity' named entity 'axons' named entity 'Delrin' named entity 'inoculation' named entity 'olfactometer' named entity 'anosmia' named entity 'lateral olfactory tract' named entity 'dendrites' named entity 'anosmia'

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