About: Intranasal Inoculation with the Olfactory Bulb Line Variant of Mouse Hepatitis Virus Causes Extensive Destruction of the Olfactory Bulb and Accelerated Turnover of Neurons in the Olfactory Epithelium of Mice

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About: Intranasal Inoculation with the Olfactory Bulb Line Variant of Mouse Hepatitis Virus Causes Extensive Destruction of the Olfactory Bulb and Accelerated Turnover of Neurons in the Olfactory Epithelium of Mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Intranasal Inoculation with the Olfactory Bulb Line Variant of Mouse Hepatitis Virus Causes Extensive Destruction of the Olfactory Bulb and Accelerated Turnover of Neurons in the Olfactory Epithelium of Mice
Creator	Jubelt, Burk Saha, Sucharita Schwob, James Youngentob, Steven
Source	Medline; PMC
abstract	Viral upper respiratory infections are the most common cause of clinical olfactory dysfunction, but the pathogenesis of dysosmia after viral infection is poorly understood. Biopsies of the olfactory mucosa in patients that complain of dysosmia after viral infection fall into two categories: one in which no olfactory epithelium is seen and another in which the epithelium is disordered and populated mainly by immature neurons. We have used intranasal inoculation with an olfactory bulb line variant of MHV to study the consequences of viral infection on peripheral olfactory structures. MHV OBLV has little direct effect on the olfactory epithelium, but causes extensive spongiotic degeneration and destruction of mitral cells and interneurons in the olfactory bulb such that the axonal projection from the bulb via the lateral olfactory tract is markedly reduced. Moreover, surviving mitral cells apparently remain disconnected from the sensory neuron input to the glomerular layer, judging from retrograde labeling studies using Dil. The damage to the bulb indirectly causes a persistent, long-term increase in the turnover of sensory neurons in the epithelium, i.e. the relative proportion of immature to mature sensory neurons and the rate of basal cell proliferation both increase. The changes that develop after inoculation with MHV OBLV closely resemble the disordering of the olfactory epithelium in some patient biopsies. Thus, damage to the olfactory nerve or bulb may contribute to a form of post-viral olfactory dysfunction and MHV OBLV is a useful model for studying the pathogenesis of this form of dysosmia.
has issue date	2001-10-01(xsd:dateTime)
bibo:doi	10.1093/chemse/26.8.937
bibo:pmid	11595671
has license	no-cc
schema:url	https://doi.org/10.1093/chemse/26.8.937
resource representing a document's title	Intranasal Inoculation with the Olfactory Bulb Line Variant of Mouse Hepatitis Virus Causes Extensive Destruction of the Olfactory Bulb and Accelerated Turnover of Neurons in the Olfactory Epithelium of Mice
has PubMed Central identifier	PMC7110028
has PubMed identifier	11595671
schema:publication	Chem Senses
resource representing a document's body	covid:PMC7110028#body_text
is schema:about of	named entity 'Inoculation' named entity 'INTRANASAL INOCULATION' named entity 'LINE' named entity 'TURNOVER' named entity 'NEURONS' named entity 'Olfactory Bulb' named entity 'Inoculation' named entity 'Olfactory Epithelium' named entity 'Intranasal' named entity 'Olfactory Bulb' named entity 'Neurons' named entity 'infection' named entity 'epithelium' named entity 'infection' named entity 'virus' named entity 'Plexiglas' named entity 'infection' named entity 'mice' named entity 'epithelium' named entity 'the animals' named entity 'LOT' named entity 'nucleolus' named entity 'phosphate' named entity 'CNS' named entity 'Rockville, MD' named entity 'olfactory bulb' named entity 'granule cells' named entity 'perfused' named entity 'biopsies' named entity 'sensory neurons' named entity 'sensory neurons' named entity 'virulent' named entity 'nostril' named entity 'spleen' named entity 'hematoxylin' named entity 'neurons' named entity 'ad libitum' named entity 'liver' named entity 'piriform cortex' named entity 'sensory neurons' named entity 'negatively correlated' named entity 'sensory neurons' named entity 'olfactory' named entity 'spongiosis' named entity 'mice' named entity 'tufted cells' named entity 'anesthesia' named entity 'inoculum' named entity 'agglutinin' named entity 'virus' named entity 'caudal' named entity 'anterior olfactory nucleus' named entity 'neurons' named entity 'endogenous' named entity 'granule cells' named entity 'lesion' named entity 'Soft tissues' named entity 'SEM' named entity 'mucosa' named entity 'immunoglobulins' named entity 'inflammation' named entity 'inoculation' named entity 'mice' named entity 'titrate' named entity 'basal cells' named entity 'inoculation' named entity 'respiratory epithelium' named entity 'inflammatory' named entity 'piriform cortex' named entity 'mice' named entity 'kDa' named entity 'epithelium' named entity 'inoculation' named entity 'MHV' named entity 'RT-PCR' named entity 'LOT' named entity 'systemic disease' named entity 'Virus' named entity 'infection'

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