About: First report of human salivirus/klassevirus in respiratory specimens of a child with fatal adenovirus infection

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About: First report of human salivirus/klassevirus in respiratory specimens of a child with fatal adenovirus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	First report of human salivirus/klassevirus in respiratory specimens of a child with fatal adenovirus infection
Creator	Jiang, Hui Li, Meng Deng, Jikui Ma, Jinmin Li, Jiandong Xu, Fengping Ji, Jingkai Xu, Xun Hou, Yong Lu, Haorong Wei, Xuemei Li, Liqiang Pei, Na Sun, Yisuo Zhang, Jiaosheng Zhang, Ruimu
Source	PMC
abstract	Adenovirus is a leading cause of respiratory infection in children. Salivirus/klassevirus was first identified as an etiologic agent of gastroenteritis and was never reported in respiratory infection cases. The case being discussed here caught our attention because, although it is a common respiratory infection, it was fatal, while similar cases were mild. In order to find potential causes in the fatal case, we describe the clinical diagnosis and treatment, the sequencing analysis of the salivirus/klassevirus, and the co-infectious adenovirus. Metagenomics sequencing was conducted on the samples from a nasopharyngeal swab of the children with adenovirus infection. Sequences were assembled using IDBA-ud (1.1.1); phylogenetic analysis was performed using MEGA 5.2. RT-PCR and quantitative PCR were performed to verify the existence of the virus in the samples. A nearly full genome of this new virus strain was obtained with 7633 nt encoding a polyprotein of 2331 aa. Meanwhile, it was detected specifically in the nasopharyngeal swab by RT-PCR. Further, homology analysis indicated that the virus has a closer relationship with Salivirus A strain in Shanghai (GU245894). Our study reports the first case of Human salivirus/klassevirus in respiratory specimens of a child with fatal adenovirus infection in Shenzhen, China. The finding and investigation of the virus will provide more useful information for the clinical diagnosis of unexplained lethal infection and expand our knowledge of the new family, salivirus/klassevirus in picornavirus. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11262-016-1361-7) contains supplementary material, which is available to authorized users.
has issue date	2016-06-17(xsd:dateTime)
bibo:doi	10.1007/s11262-016-1361-7
bibo:pmid	27314269
has license	cc-by
schema:url	https://doi.org/10.1007/s11262-016-1361-7
resource representing a document's title	First report of human salivirus/klassevirus in respiratory specimens of a child with fatal adenovirus infection
has PubMed Central identifier	PMC5002279
has PubMed identifier	27314269
schema:publication	Virus Genes
resource representing a document's body	covid:PMC5002279#body_text
is schema:about of	named entity 'salivirus' named entity 'adenovirus infection' named entity 'primers' named entity 'etiologic agent' named entity 'Bacterial cultures' named entity 'nasopharyngeal swab' named entity 'amino acid' named entity 'sanger sequencing' named entity 'salivirus' named entity 'GenBank' named entity 'lungs' named entity 'Shenzhen' named entity 'salivirus' named entity 'picornavirus' named entity 'adenovirus' named entity 'contigs' named entity 'virus strain' named entity 'Homology' named entity 'RT-PCR' named entity '0.98' named entity 'primers' named entity 'supplemental oxygen' named entity 'RSV' named entity 'pneumonia' named entity 'PCR' named entity 'adenovirus' named entity 'antigen' named entity 'PCR' named entity 'Salivirus' named entity 'virus' named entity 'crackles' named entity 'NCBI' named entity 'adenovirus' named entity 'primers' named entity 'Metagenomics' named entity 'albuterol' named entity 'picornavirus' named entity 'lesion' named entity 'Hepatovirus' named entity 'adenoviruses' named entity 'nasopharyngeal swab' named entity 'virus' named entity 'RT-PCR' named entity 'direct immunofluorescence' named entity 'virus' named entity 'contigs' named entity 'co-linearity' named entity 'virus' named entity 'respiratory infection' named entity 'co-infection' named entity 'cDNA' named entity 'Shanghai' named entity 'infectious disease' named entity 'Picornaviruses' named entity 'nasopharyngeal swab' named entity 'serum' named entity 'salivirus' named entity 'genome' named entity 'salivirus' named entity 'genome' named entity 'gastroenteritis' named entity 'ARDS' named entity 'adenovirus' named entity 'respiratory infection' named entity 'adenovirus' named entity 'gene' named entity 'clinical significance'

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