About: The Ebola Virus Glycoprotein and HIV-1 Vpu Employ Different Strategies to Counteract the Antiviral Factor Tetherin

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Ebola Virus Glycoprotein and HIV-1 Vpu Employ Different Strategies to Counteract the Antiviral Factor Tetherin
Creator	Feldmann, Heinz Bertram, Stephanie Pöhlmann, Stefan Marzi, Andrea Schindler, Michael Guo, Ju-Tao Glowacka, Ilona Kühl, Annika Steffen, Imke Schubert, Ulrich Banning, Carina Behrens, Georg Konrad, Andreas Stürzl, Michael Votteler, Jörg
source	PMC
abstract	The antiviral protein tetherin/BST2/CD317/HM1.24 restricts cellular egress of human immunodeficiency virus (HIV) and of particles mimicking the Ebola virus (EBOV), a hemorrhagic fever virus. The HIV-1 viral protein U (Vpu) and the EBOV-glycoprotein (EBOV-GP) both inhibit tetherin. Here, we compared tetherin counteraction by EBOV-GP and Vpu. We found that EBOV-GP but not Vpu counteracted tetherin from different primate species, indicating that EBOV-GP and Vpu target tetherin differentially. Tetherin interacted with the GP2 subunit of EBOV-GP, which might encode the determinants for tetherin counteraction. Vpu reduced cell surface expression of tetherin while EBOV-GP did not, suggesting that both proteins employ different mechanisms to counteract tetherin. Finally, Marburg virus (MARV)–GP also inhibited tetherin and downregulated tetherin in a cell type–dependent fashion, indicating that tetherin antagonism depends on the cellular source of tetherin. Collectively, our results indicate that EBOV-GP counteracts tetherin by a novel mechanism and that tetherin inhibition is conserved between EBOV-GP and MARV-GP.
has issue date	2011-11-01(xsd:dateTime)
bibo:doi	10.1093/infdis/jir378
bibo:pmid	21987761
has license	bronze-oa
schema:url	https://doi.org/10.1093/infdis/jir378
resource representing a document's title	The Ebola Virus Glycoprotein and HIV-1 Vpu Employ Different Strategies to Counteract the Antiviral Factor Tetherin
has PubMed Central identifier	PMC3189996
has PubMed identifier	21987761
schema:publication	The Journal of Infectious Diseases
resource representing a document's body	covid:PMC3189996#body_text
is schema:about of	named entity 'Vpu' named entity 'Ebola' named entity 'HIV-1' named entity 'Tetherin' named entity 'HIV-1' named entity 'supernatants' named entity 'transmembrane domains' named entity 'tetherin' named entity 'transfected' named entity 'tetherin' named entity 'tetracycline' named entity 'primary and secondary antibodies' named entity 'ZEBOV' named entity 'NIH' named entity 'tetherin' named entity 'tetherin' named entity 'EBOV' named entity 'viral RNA' named entity 'tetherin' named entity 'endogenous' named entity 'tetherin' named entity 'VP40' named entity 'EBOV' named entity 'tetherin' named entity 'positive control' named entity 'tetherin' named entity 'IFNα' named entity 'sequence identity' named entity 'tetherin' named entity 'fluorescence resonance energy transfer' named entity 'HeLa cells' named entity 'tetherin' named entity 'transmembrane protein' named entity 'FRET' named entity 'Tetherin' named entity 'tetherin' named entity 'Kaposi’s sarcoma' named entity 'EBOV' named entity 'tetherin' named entity 'tetherin' named entity 'cytoplasmic' named entity 'amino acid' named entity 'supernatants' named entity 'extracellular' named entity 'tetherin' named entity 'tetherin' named entity 'MOI' named entity 'vector' named entity 'GP2' named entity 'tetherin' named entity 'tetherin' named entity 'tetherin' named entity 'ZEBOV' named entity 'N-terminus' named entity 'tetherin' named entity 'C-terminus' named entity 'alleles' named entity 'YFP' named entity 'ZEBOV' named entity 'tetherin' named entity 'tetherin' named entity 'tetherin' named entity 'sodium dodecyl sulfate' named entity 'transfected' named entity 'tetherin' named entity 'VP40' named entity '293T cells' named entity 'FITC'

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