About: Epithelial barriers in allergy and asthma

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epithelial barriers in allergy and asthma
Creator	Hellings, Peter Steelant, Brecht
Source	Elsevier; Medline; PMC
abstract	The respiratory epithelium provides a physical, functional, and immunologic barrier to protect the host from the potential harming effects of inhaled environmental particles and to guarantee maintenance of a healthy state of the host. When compromised, activation of immune/inflammatory responses against exogenous allergens, microbial substances, and pollutants might occur, rendering individuals prone to develop chronic inflammation as seen in allergic rhinitis, chronic rhinosinusitis, and asthma. The airway epithelium in asthma and upper airway diseases is dysfunctional due to disturbed tight junction formation. By putting the epithelial barrier to the forefront of the pathophysiology of airway inflammation, different approaches to diagnose and target epithelial barrier defects are currently being developed. Using single-cell transcriptomics, novel epithelial cell types are being unraveled that might play a role in chronicity of respiratory diseases. We here review and discuss the current understandings of epithelial barrier defects in type 2–driven chronic inflammation of the upper and lower airways, the estimated contribution of these novel identified epithelial cells to disease, and the current clinical challenges in relation to diagnosis and treatment of allergic rhinitis, chronic rhinosinusitis, and asthma.
has issue date	2020-06-04(xsd:dateTime)
bibo:doi	10.1016/j.jaci.2020.04.010
bibo:pmid	32507228
has license	no-cc
sha1sum (hex)	9febf5b47065f7e1ae01ac052b7fc0ab340e6ccd
schema:url	https://doi.org/10.1016/j.jaci.2020.04.010
resource representing a document's title	Epithelial barriers in allergy and asthma
has PubMed Central identifier	PMC7270816
has PubMed identifier	32507228
schema:publication	J Allergy Clin Immunol
resource representing a document's body	covid:9febf5b47065f7e1ae01ac052b7fc0ab340e6ccd#body_text
is schema:about of	named entity 'allergy' named entity 'asthma' named entity 'Epithelial' named entity 'asthma' named entity 'allergy' named entity 'fluorescence' named entity 'Cftr' named entity 'rhinitis' named entity 'mucus layer' named entity 'ciliated' named entity 'Mucus' named entity 'lower airway' named entity 'permeability' named entity 'permeability' named entity 'intermediate filament' named entity 'epithelial cells' named entity 'single-cell' named entity 'chemoreceptors' named entity 'CRISPR-Cas9' named entity 'bronchoalveolar lavage fluid' named entity 'allergic' named entity 'viruses' named entity 'permeability' named entity 'cigarette smoke' named entity 'high levels' named entity 'TSLP' named entity 'pathology' named entity 'solitary chemosensory cells' named entity 'basal cells' named entity 'Trefoil' named entity 'protein superfamily' named entity 'CFTR' named entity 'HEMIDESMOSOMES' named entity 'inflammation' named entity 'asthma' named entity 'epithelial layer' named entity 'fungal rhinosinusitis' named entity 'CDHR3' named entity 'RNA' named entity 'asthma' named entity 'biomarkers' named entity 'ATPases' named entity 'epithelial' named entity 'epithelial cells' named entity 'epithelial cells' named entity 'epithelial' named entity 'permeability' named entity 'viscosity' named entity 'HDAC11' named entity 'IL-4 receptor' named entity 'epithelial' named entity 'blood vessels' named entity 'paracellularly' named entity 'epithelial barrier' named entity 'epithelial' named entity 'epithelial' named entity 'asthma' named entity 'epithelial barrier' named entity 'epithelial' named entity 'proton' named entity 'E-cadherin' named entity 'Solitary chemosensory cells' named entity 'pathogens' named entity 'epithelial barrier' named entity 'immune cells' named entity 'allergen' named entity 'epithelial' named entity 'SINGLE-CELL' named entity 'epithelial' named entity 'basal cells' named entity 'epithelial' named entity 'genomes' named entity 'epithelial' named entity 'respiratory disease' named entity 'asthma' named entity 'Junctional complexes' named entity 'CRISPR-CAS9' named entity 'downregulated' named entity 'asthma' named entity 'HDAC1'

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