About: Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM
Creator	Perlman, Stanley Perlman, S Ae, Steven Perlman, Á Res, Immunol Templeton, S
Source	Medline; PMC
abstract	Infection of mice with variants of mouse hepatitis virus, strain JHM (MHV-JHM), provide models of acute and chronic viral infection of the central nervous system (CNS). Through targeted recombination and reverse genetic manipulation, studies of infection with MHV-JHM variants have identified phenotypic differences and examined the effects of these differences on viral pathogenesis and anti-viral host immune responses. Studies employing recombinant viruses with a modified spike (S) glycoprotein of MHV-JHM have identified the S gene as a major determinant of neurovirulence. However, the association of S gene variation and neurovirulence with host ability to generate anti-viral CD8 T cell responses is not completely clear. Partially protective anti-viral immune responses may result in persistent infection and chronic demyelinating disease characterized by myelin removal from axons of the CNS and associated with dense macrophage/microglial infiltration. Demyelinating disease during MHV-JHM infection is immune-mediated, as mice that lack T lymphocytes fail to develop disease despite succumbing to encephalitis with high levels of infectious virus in the CNS. However, the presence of T lymphocytes or anti-viral antibody can induce disease in infected immunodeficient mice. The mechanisms by which these immune effectors induce demyelination share an ability to activate and recruit macrophages and microglia, thus increasing the putative role of these cells in myelin destruction.
has issue date	2007-06-01(xsd:dateTime)
bibo:doi	10.1007/s12026-007-0079-y
bibo:pmid	17917063
has license	no-cc
sha1sum (hex)	9fdaea29b56a775bb744d83dc53efa52f55be1ed
schema:url	https://doi.org/10.1007/s12026-007-0079-y
resource representing a document's title	Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM
has PubMed Central identifier	PMC7090838
has PubMed identifier	17917063
schema:publication	Immunol Res
resource representing a document's body	covid:9fdaea29b56a775bb744d83dc53efa52f55be1ed#body_text
is schema:about of	named entity 'ACUTE' named entity 'encephalitis' named entity 'viruses' named entity 'immunodeficient' named entity 'models' named entity 'reverse' named entity 'anti-viral' named entity 'T cell' named entity 'levels' named entity 'antibody' named entity 'host' named entity 'determinant' named entity 'mouse' named entity 'INFILTRATION' named entity 'THESE' named entity 'VIRAL INFECTION' named entity 'RECOMBINATION' named entity '28S' named entity 'COMPLETELY' named entity 'T LYMPHOCYTES' named entity 'INFECTION' named entity 'MOUSE HEPATITIS VIRUS' named entity 'STRAIN' named entity 'ACTIVATE' named entity 'MYELIN' named entity 'VARIANTS' named entity 'CHARACTERIZED' named entity 'RESULT' named entity 'STUDIES' named entity 'REVERSE' named entity 'DEMYELINATION' named entity 'DEMYELINATING DISEASE' named entity 'VIRAL' named entity 'ACUTE' named entity 'CHRONIC' named entity 'RECOMBINANT' named entity 'T CELL' named entity 'DISEASE' named entity 'PRESENCE OF' named entity 'NEUROVIRULENCE' named entity 'MICE' covid:arg/9fdaea29b56a775bb744d83dc53efa52f55be1ed named entity 'INDUCE' named entity 'MODIFIED' named entity 'REMOVAL' named entity 'VIRUS' named entity 'VIRAL ANTIBODY' named entity 'TARGETED' named entity 'LACK' named entity 'MICROGLIA' named entity 'EXAMINED' named entity 'CD8' named entity 'A MAJOR' named entity 'HOST' named entity 'HAVE' named entity 'FAIL' named entity 'DETERMINANT' named entity 'ASSOCIATION' named entity 'MODELS' named entity 'GLYCOPROTEIN' named entity 'GENE' named entity 'VARIANTS' named entity 'CENTRAL NERVOUS SYSTEM INFECTION' named entity 'HIGH' named entity 'ROLE' named entity 'VIRUSES' named entity 'INCREASING' named entity 'PATHOGENESIS' named entity 'MOUSE HEPATITIS VIRUS' named entity 'CHRONIC' named entity 'STRAIN' named entity 'MACROPHAGES' named entity 'CELLS' named entity 'SHARE' named entity 'GENE VARIATION' named entity 'DENSE'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software