About: Interferon-λ in the Context of Viral Infections: Production, Response and Therapeutic Implications

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Interferon-λ in the Context of Viral Infections: Production, Response and Therapeutic Implications Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon-λ in the Context of Viral Infections: Production, Response and Therapeutic Implications
Creator	Michiels, Thomas Hermant, Pascale
Source	Medline; PMC
abstract	Interferon (IFN)-λ forms the type III IFN family. Although they signal through distinct receptors, type I (IFN-α/β) and type III IFNs elicit remarkably similar responses in cells. However, in vivo, type III and type I IFN responses are not fully redundant as their respective contribution to the antiviral defense highly depends on virus species. IFN-λ is much more potent than IFN-α/β at controlling rotavirus infection. In contrast, clearance of several other viruses, such as influenza virus, mostly depends on IFN-α/β. The IFN-λ receptor was reported to be preferentially expressed on epithelial cells. Cells responsible for IFN-λ production are still poorly characterized but seem to overlap only partly IFN-α/β-producing cells. Accumulating data suggest that epithelial cells are also important IFN-λ producers. Thus, IFN-λ may primarily act as a protection of mucosal entities, such as the lung, skin or digestive tract. Type I and type III IFN signal transduction pathways largely overlap, and cross talk between these IFN systems occurs. Finally, this review addresses the potential benefit of IFN-λ use for therapeutic purposes and summarizes recent results of genome-wide association studies that identified polymorphisms in the region of the IFN-λ3 gene impacting on the outcome of treatments against hepatitis C virus infection.
has issue date	2014-01-01(xsd:dateTime)
bibo:doi	10.1159/000360084
bibo:pmid	24751921
has license	green-oa
sha1sum (hex)	9fd9a616a587f16cac40684045df0398fc7152e4
schema:url	https://doi.org/10.1159/000360084
resource representing a document's title	Interferon-λ in the Context of Viral Infections: Production, Response and Therapeutic Implications
has PubMed Central identifier	PMC6741612
has PubMed identifier	24751921
schema:publication	Journal of Innate Immunity
resource representing a document's body	covid:9fd9a616a587f16cac40684045df0398fc7152e4#body_text
is schema:about of	named entity 'antiviral' named entity 'lung' named entity 'redundant' named entity 'type' named entity 'impacting' named entity 'influenza' named entity 'vivo' named entity 'production' named entity 'cells' named entity 'skin' named entity 'IFN-α' named entity 'addresses' named entity 'polymorphisms' named entity 'clearance' named entity 'responses' named entity 'gene' named entity 'hepatitis C virus' named entity 'IFN-α/β' named entity 'IFN-α/β' named entity 'IFN-λ' named entity 'antiviral' named entity 'IFN-α/β' named entity 'IFN-λ' named entity 'IFN-λ' named entity 'IFN-λ' named entity 'lung' named entity 'ISGs' named entity 'gene expression' named entity 'virus' named entity 'hepatocytes' named entity 'virus' named entity 'IFN-λ' named entity 'IFN-λ' named entity 'IFN-λ' named entity 'type I' named entity 'IFN-λ' named entity 'STAT1' named entity 'cell types' named entity 'type I IFNs' named entity 'hepatocytes' named entity 'IFN-λ' named entity 'NF-κB' named entity 'IFN-β' named entity 'cultured cells' named entity 'cell line' named entity 'upregulate' named entity 'stomach' named entity 'IFNLR1' named entity 'IFN' named entity 'protein' named entity 'pDCs' named entity 'cell lines' named entity 'mRNA expression' named entity 'cell lines' named entity 'RIG-I' named entity 'liver cells' named entity 'Listeria monocytogenes' named entity 'mice' named entity 'IFN-λ' named entity 'intestine' named entity 'TLRs' named entity 'IFN-λ' named entity 'mice' named entity 'virological' named entity 'response elements' named entity 'vesicular stomatitis virus' named entity 'liver cells' named entity 'pegylated' named entity 'wild-type' named entity 'pDCs' named entity 'type I IFNs' named entity 'IFN-β' named entity 'IFN-λ' named entity 'IFNAR' named entity 'aminotransferase' named entity 'IFN-λ' named entity 'Huh7' named entity '3, 4' named entity 'IFN-λ' named entity 'IFN-λ'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software