About: Houttuynia cordata inhibits lipopolysaccharide-induced rapid pulmonary fibrosis by up-regulating IFN-γ and inhibiting the TGF-β1/Smad pathway

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About: Houttuynia cordata inhibits lipopolysaccharide-induced rapid pulmonary fibrosis by up-regulating IFN-γ and inhibiting the TGF-β1/Smad pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Houttuynia cordata inhibits lipopolysaccharide-induced rapid pulmonary fibrosis by up-regulating IFN-γ and inhibiting the TGF-β1/Smad pathway
Creator	Li, Hui Yang, Jun Zhang, Rong Huang, Wei Chen, Dongfeng Chen, Yangyan Cui, Yinghai Du, Shaohui Huang, Haiyuan Li, Yiwei Wei, Zhijun Wu, Jingjing Yang, Lina Zhang, Saixia Zhou, Jianhong Chow, Ngai
Source	Elsevier; Medline; PMC
abstract	This study aimed to explore the effect and mechanism of H. cordata vapor extract on acute lung injury (ALI) and rapid pulmonary fibrosis (RPF). We applied the volatile extract of HC to an RPF rat model and analyzed the effect on ALI and RPF using hematoxylin–eosin (H&E) staining, routine blood tests, a cell count of bronchoalveolar lavage fluid (BALF), lactate dehydrogenase (LDH) content, van Gieson (VG) staining, hydroxyproline (Hyp) content and the dry/wet weight ratio. The expression of IFN-γ/STAT(1), IL-4/STAT(6) and TGF-β(1)/Smads was analyzed using ELISA, immunohistochemistry and western blotting methods. The active ingredients of the HC vapor extract were analyzed using a gas chromatograph–mass spectrometer (GC–MS), and the effects of the active ingredients of HC on the viability of NIH/3T3 and RAW264.7 cells were detected using an MTT assay. The active ingredients of the HC vapor extract included 4-terpineol, α-terpineol, l-bornyl acetate and methyl-n-nonyl ketone. The results of the lung H&E staining, Hyp content, dry/wet weight ratio and VG staining suggested that the HC vapor extract repaired lung injury and reduced RPF in a dose-dependent manner and up-regulated IFN-γ and inhibited the TGF-β1/Smad pathway in vivo. In vitro, it could inhibit the viability of RAW264.7 and NIH/3T3 cells. It also dose-dependently inhibited the expression of TGF-β1 and enhanced the expression of IFN-γ in NIH/3T3. The HC vapor extract inhibited LPS-induced RPF by up-regulating IFN-γ and inhibiting the TGF-β1/Smad pathway.
has issue date	2012-05-02(xsd:dateTime)
bibo:doi	10.1016/j.intimp.2012.03.011
bibo:pmid	22561446
has license	no-cc
sha1sum (hex)	9fba52385c27606467ccd9f98d44dd61290eb5cf
schema:url	https://doi.org/10.1016/j.intimp.2012.03.011
resource representing a document's title	Houttuynia cordata inhibits lipopolysaccharide-induced rapid pulmonary fibrosis by up-regulating IFN-γ and inhibiting the TGF-β1/Smad pathway
has PubMed Central identifier	PMC7106082
has PubMed identifier	22561446
schema:publication	Int Immunopharmacol
resource representing a document's body	covid:9fba52385c27606467ccd9f98d44dd61290eb5cf#body_text
is schema:about of	named entity 'INHIBITING' named entity 'INDUCED' named entity 'REGULATING' named entity 'effects' named entity 'hydroxyproline' named entity 'reduced' named entity 'TGF-β1' named entity 'acute lung injury' named entity 'rapid' named entity 'Houttuynia' named entity 'IFN' named entity 'PATHWAY' named entity 'PATHWAY' named entity 'ROUTINE' named entity 'VAN GIESON' named entity 'CONTENT' named entity 'IN VIVO' named entity 'DETECTED' named entity 'USING' named entity 'DOSE-DEPENDENT' named entity 'A CELL' named entity 'REDUCED' named entity 'IL-4' named entity 'INDUCED' named entity 'BLOOD TESTS' named entity 'INCLUDED' named entity 'STAINING' named entity 'REPAIRED' named entity 'LPS' named entity 'B21' named entity 'UP-REGULATED' named entity 'BRONCHOALVEOLAR LAVAGE FLUID' named entity '28H' named entity '4-TERPINEOL' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'RAT MODEL' named entity 'ANALYZED' named entity 'KETONE' named entity 'LUNG' named entity 'EFFECT' named entity 'LIPOPOLYSACCHARIDE' named entity 'DOSE' named entity 'RAPID' named entity 'PULMONARY FIBROSIS' named entity 'RAPID' named entity 'REGULATING' named entity 'NIH' named entity 'IN VITRO' named entity 'MTT ASSAY' named entity 'B21' named entity 'STUDY' named entity 'EXPRESSION' named entity 'RAW264.7' named entity 'CELLS' named entity 'TERPINEOL' named entity 'INHIBITING' named entity 'HOUTTUYNIA CORDATA' named entity 'TGF' named entity 'HYDROXYPROLINE' named entity 'LUNG INJURY' named entity 'CELL COUNT' named entity 'IFN' named entity 'MECHANISM' named entity 'DRY' named entity 'RPF' named entity 'METHYL'

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