About: SYNCRIP (Synaptotagmin-Binding, Cytoplasmic RNA-Interacting Protein) Is a Host Factor Involved In Hepatitis C virus RNA Replication

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About: SYNCRIP (Synaptotagmin-Binding, Cytoplasmic RNA-Interacting Protein) Is a Host Factor Involved In Hepatitis C virus RNA Replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SYNCRIP (Synaptotagmin-Binding, Cytoplasmic RNA-Interacting Protein) Is a Host Factor Involved In Hepatitis C virus RNA Replication
Creator	Lai, Michael Aizaki, Hideki Machida, Keigo Choi, Keum Liu, Helene Ou, J.-H
Source	Elsevier; Medline; PMC
abstract	Hepatitis C virus (HCV) RNA replication requires viral nonstructural proteins as well as cellular factors. Recently, a cellular protein, synaptotagmin-binding, cytoplasmic RNA-interacting protein (SYNCRIP), also known as NSAP1, was found to bind HCV RNA and enhance HCV IRES-dependent translation. We investigate whether this protein is also involved in the HCV RNA replication. We found that SYNCRIP was associated with detergent-resistant membrane fractions and colocalized with newly-synthesized HCV RNA. Knock-down of SYNCRIP by siRNA significantly decreased the amount of HCV RNA in the cells containing a subgenomic replicon or a full-length viral RNA. Lastly, an in vitro replication assay after immunodepletion of SYNCRIP showed that SYNCRIP was directly involved in HCV RNA replication. These findings indicate that SYNCRIP has dual functions, participating in both RNA replication and translation in HCV life cycle.
has issue date	2009-04-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2009.01.018
bibo:pmid	19232660
has license	green-oa
sha1sum (hex)	9fae51ab2616267198036d17a84788ab9c586fed
schema:url	https://doi.org/10.1016/j.virol.2009.01.018
resource representing a document's title	SYNCRIP (Synaptotagmin-Binding, Cytoplasmic RNA-Interacting Protein) Is a Host Factor Involved In Hepatitis C virus RNA Replication
has PubMed Central identifier	PMC3099193
has PubMed identifier	19232660
schema:publication	Virology
resource representing a document's body	covid:9fae51ab2616267198036d17a84788ab9c586fed#body_text
is schema:about of	named entity 'BINDING' named entity 'LIFE CYCLE' named entity 'FUNCTIONS' named entity 'IMMUNODEPLETION' named entity 'PARTICIPATING' named entity 'CELLULAR' named entity 'TRANSLATION' named entity 'DETERGENT' named entity 'FINDINGS' named entity 'BIND' named entity 'INVESTIGATE' named entity 'INVOLVED' named entity 'PROTEIN' named entity 'IN VITRO' named entity 'DUAL' named entity 'PROTEIN ' named entity 'VIRAL NONSTRUCTURAL PROTEINS' named entity 'MEMBRANE' named entity 'INTERACTING' named entity 'INVOLVED' covid:arg/9fae51ab2616267198036d17a84788ab9c586fed named entity 'DIRECTLY' named entity 'NEWLY' named entity 'CONTAINING' named entity 'RECENTLY' named entity 'LENGTH' named entity 'HEPATITIS C VIRUS' named entity 'RESISTANT' named entity 'KNOCK-DOWN' named entity 'VIRAL RNA' named entity 'INTERACTING' named entity 'PROTEIN' named entity 'CYTOPLASMIC RNA' named entity 'RNA REPLICATION' named entity 'SYNCRIP' named entity 'CYTOPLASMIC RNA' named entity 'DECREASED' named entity 'REPLICATION' named entity 'RNA' named entity 'IS A' named entity 'BINDING' named entity 'CELLS' named entity 'SYNTHESIZED' named entity 'REPLICON' named entity 'SYNCRIP' named entity 'ASSAY' named entity 'ASSOCIATED WITH' named entity 'HEPATITIS C VIRUS RNA' named entity 'HOST FACTOR' named entity 'ENHANCE' named entity 'RNA REPLICATION' named entity 'FRACTIONS' named entity 'KNOWN' named entity 'SYNAPTOTAGMIN' named entity 'NSAP1' named entity 'THESE' named entity 'FOUND' named entity 'SIRNA' named entity 'HCV' named entity 'bind' named entity 'assay' named entity 'HCV' named entity 'membrane' named entity 'SYNCRIP' named entity 'RNA' named entity 'assay' named entity 'viral RNA' named entity 'detergent' named entity 'protein' named entity 'HCV' named entity 'Host Factor' named entity 'Hepatitis C virus' named entity 'RNA' named entity 'PBS' named entity 'HCV' named entity 'PBS'

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