About: Potential Therapeutic Agents and Associated Bioassay Data for COVID-19 and Related Human Coronavirus Infections

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Potential Therapeutic Agents and Associated Bioassay Data for COVID-19 and Related Human Coronavirus Infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Potential Therapeutic Agents and Associated Bioassay Data for COVID-19 and Related Human Coronavirus Infections
Creator	Li, Yingzhu Liu, Cynthia Zhou, Garner, Linda Deng, Yi Gessner, Chris Granet, Roger Kato-Weinstein, Junko Polshakov, Dmitrii Qiongqiong, Angela Watkins, Steven
Source	PMC
abstract	[Image: see text] The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has led to several million confirmed cases and hundreds of thousands of deaths worldwide. To support the ongoing research and development of COVID-19 therapeutics, this report provides an overview of protein targets and corresponding potential drug candidates with bioassay and structure–activity relationship data found in the scientific literature and patents for COVID-19 or related virus infections. Highlighted are several sets of small molecules and biologics that act on specific targets, including 3CLpro, PLpro, RdRp, S-protein–ACE2 interaction, helicase/NTPase, TMPRSS2, and furin, which are involved in the viral life cycle or in other aspects of the disease pathophysiology. We hope this report will be valuable to the ongoing drug repurposing efforts and the discovery of new therapeutics with the potential for treating COVID-19.
has issue date	2020-07-30(xsd:dateTime)
bibo:doi	10.1021/acsptsci.0c00074
has license	no-cc
sha1sum (hex)	9f9327bbb55955d210c4a2e84de8ce5e6bc55312
schema:url	https://doi.org/10.1021/acsptsci.0c00074
resource representing a document's title	Potential Therapeutic Agents and Associated Bioassay Data for COVID-19 and Related Human Coronavirus Infections
has PubMed Central identifier	PMC7447080
schema:publication	ACS Pharmacol Transl Sci
resource representing a document's body	covid:9f9327bbb55955d210c4a2e84de8ce5e6bc55312#body_text
is schema:about of	named entity 'data' named entity 'patents' named entity 'targets' named entity 'ongoing' named entity 'NTPase' named entity 'targets' named entity 'biologics' named entity 'TMPRSS2' named entity 'Infections' named entity 'Data' named entity 'ACT' named entity 'specific' named entity 'therapeutics' named entity 'caused' named entity 'treating' named entity 'helicase' named entity 'hope' named entity 'PLpro' named entity 'bioassay' named entity 'drug repurposing' named entity 'small molecules' named entity 'COVID-19' named entity 'helicase' named entity 'RdRp' named entity 'CD147' named entity 'host cells' named entity 'SARS-CoV' named entity 'COVID' named entity '3CLpro' named entity 'spike (S) protein' named entity 'ACE2' named entity 'clinical trials' named entity 'K i' named entity 'antimalarial' named entity 'Chemical Abstract Services' named entity 'kidney' named entity 'half maximal effective concentration' named entity 'ssRNA' named entity 'heptad repeat' named entity 'TMPRSS2' named entity 'Small Molecules' named entity 'virus' named entity 'COVID' named entity 'corticosteroids' named entity 'immune cells' named entity 'SARS-CoV-2' named entity 'tenofovir alafenamide' named entity 'coronavirus' named entity 'chloroquine' named entity 'Small-Molecule' named entity 'respiratory support' named entity 'ACE2' named entity 'CAS Registry Number' named entity 'peptides' named entity 'protein' named entity 'Viral Entry' named entity 'hydroxychloroquine' named entity 'TMPRSS2' named entity 'respiratory support' named entity 'tumor necrosis factor α' named entity 'SARS-CoV' named entity 'plasma' named entity 'viral replication' named entity 'SARS-CoV' named entity 'NTPase' named entity 'hydroxychloroquine' named entity 'viral replication' named entity 'Infection' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'MERS-CoV' named entity 'PLpro' named entity 'structural proteins'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software