About: Coordinated Destruction of Cellular Messages in Translation Complexes by the Gammaherpesvirus Host Shutoff Factor and the Mammalian Exonuclease Xrn1

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About: Coordinated Destruction of Cellular Messages in Translation Complexes by the Gammaherpesvirus Host Shutoff Factor and the Mammalian Exonuclease Xrn1 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coordinated Destruction of Cellular Messages in Translation Complexes by the Gammaherpesvirus Host Shutoff Factor and the Mammalian Exonuclease Xrn1
Creator	Covarrubias, Sergio Wong, Wesley Glaunsinger, Britt Gaglia, Marta Jackson, Andrew Renuka Kumar, G
Source	Medline; PMC
abstract	Several viruses encode factors that promote host mRNA degradation to silence gene expression. It is unclear, however, whether cellular mRNA turnover pathways are engaged to assist in this process. In Kaposi's sarcoma-associated herpesvirus this phenotype is enacted by the host shutoff factor SOX. Here we show that SOX-induced mRNA turnover is a two-step process, in which mRNAs are first cleaved internally by SOX itself then degraded by the cellular exonuclease Xrn1. SOX therefore bypasses the regulatory steps of deadenylation and decapping normally required for Xrn1 activation. SOX is likely recruited to translating mRNAs, as it cosediments with translation initiation complexes and depletes polysomes. Cleaved mRNA intermediates accumulate in the 40S fraction, indicating that recognition occurs at an early stage of translation. This is the first example of a viral protein commandeering cellular mRNA turnover pathways to destroy host mRNAs, and suggests that Xrn1 is poised to deplete messages undergoing translation in mammalian cells.
has issue date	2011-10-27(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1002339
bibo:pmid	22046136
has license	cc-by
sha1sum (hex)	9f8273bc745daf5c556f52ab081af19bb679db36
schema:url	https://doi.org/10.1371/journal.ppat.1002339
resource representing a document's title	Coordinated Destruction of Cellular Messages in Translation Complexes by the Gammaherpesvirus Host Shutoff Factor and the Mammalian Exonuclease Xrn1
has PubMed Central identifier	PMC3203186
has PubMed identifier	22046136
schema:publication	PLoS Pathog
resource representing a document's body	covid:9f8273bc745daf5c556f52ab081af19bb679db36#body_text
is schema:about of	named entity 'host' named entity 'mRNAs' named entity 'SOX' named entity 'engaged' covid:arg/9f8273bc745daf5c556f52ab081af19bb679db36 named entity 'deadenylation' named entity 'factors' named entity 'Xrn1' named entity 'turnover' named entity 'recruited' named entity 'mRNA degradation' named entity 'mRNAs' named entity 'silence gene expression' named entity 'mammalian cells' named entity 'polysomes' named entity 'translation initiation' named entity 'Mammalian' named entity '40S' named entity 'mRNA degradation' named entity 'RNAs' named entity 'UTR' named entity 'effector' named entity 'wild-type' named entity 'viral RNAs' named entity 'endogenous' named entity 'Pol III' named entity 'exosome' named entity 'mRNA' named entity 'vector' named entity 'loading control' named entity 'oncogenic' named entity 'mRNA' named entity 'exonucleases' named entity 'enzyme' named entity 'dominant negative' named entity '40S' named entity 'Pol III' named entity 'RNP' named entity 'RNAs' named entity 'mRNA' named entity 'RNases' named entity 'GFP' named entity 'mRNAs' named entity '40S' named entity 'noncoding RNAs' named entity 'ThermoScientific' named entity 'mRNA degradation' named entity 'ribonucleoprotein' named entity 'cleavage site' named entity 'crystal structures' named entity 'Western blots' named entity 'eukaryotic mRNA' named entity 'microRNAs' named entity 'protein' named entity '293T cells' named entity 'mRNA' named entity 'initiation complex' named entity 'GFP' named entity 'RNP' named entity 'KSHV' named entity 'RNA' named entity 'viral genome' named entity 'interact' named entity 'KSHV' named entity 'polysome profiling' named entity 'gene expression' named entity 'GFP' named entity 'exonuclease' named entity 'EBV' named entity 'nucleotides' named entity 'protein' named entity 'substrates' named entity 'Dunnett's test' named entity 'ppat' named entity 'mRNAs' named entity 'DNA binding'

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