About: Extreme thrombocytosis in a young cat

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Extreme thrombocytosis in a young cat
Creator	Hooijberg, E Hooijberg, Emma Kirtz, G Kirtz, Georges Leidinger, E Leidinger, Ernst Pichler, M Pichler, Mario
source	Medline; PMC
abstract	A 7-month-old unvaccinated domestic shorthair cat was presented with a history of inappetence and hypersalivation. Clinical examination revealed fever, gingivitis and oral ulceration. An initial blood sample revealed a severe leukopenia and neutropenia and a feline panleukopenia virus (FPV) titre of 1:640; a second titre 10 days later was 1:2,560. A feline calicivirus (FCV) titre was 1:320 and the initial clinical signs and laboratory findings were attributed to a coinfection with FPV and FCV. The cat was treated with interferon omega. A blood sample taken 10 days later revealed a severe thrombocytosis of 3,448 × 10(9)/L (reference range 200–500 × 10(9)/L) confirmed by blood smear examination. The platelet count on day 35 was 4,990 × 10(9)/L. No bone marrow examination was carried out. Two differential diagnoses for an extreme thrombocytosis are a reactive thrombocytosis or essential thrombocythemia (ET). ET is a hemic neoplasia that causes a severe and persistent thrombocytosis, and is a diagnosis of exclusion. Reactive thrombocytosis is generally mild to moderate and of shorter duration than described here, but an excessive response could have been caused by infection. The influence of additional factors such as an initial thrombocytopenia, age and interferon treatment are not clear but can be speculated on. Although the exact pathophysiology in this case remains unclear, such high, persistent thrombocyte numbers have not been reported in cats in the absence of a neoplastic process.
has issue date	2010-06-09(xsd:dateTime)
bibo:doi	10.1007/s00580-010-1036-z
bibo:pmid	32214969
has license	no-cc
sha1sum (hex)	9f72ab59f57798308fd729d3c110e9f2a6f3bc6d
schema:url	https://doi.org/10.1007/s00580-010-1036-z
resource representing a document's title	Extreme thrombocytosis in a young cat
has PubMed Central identifier	PMC7087589
has PubMed identifier	32214969
schema:publication	Comp Clin Path
resource representing a document's body	covid:9f72ab59f57798308fd729d3c110e9f2a6f3bc6d#body_text
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