About: A possible link between recurrent upper respiratory tract infections and lower cytokine production in patients with Q fever fatigue syndrome

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About: A possible link between recurrent upper respiratory tract infections and lower cytokine production in patients with Q fever fatigue syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A possible link between recurrent upper respiratory tract infections and lower cytokine production in patients with Q fever fatigue syndrome
Creator	Bleeker-Rovers, Chantal Joosten, Leo Netea, Mihai Van Der Meer, Jos Jansen, Anne Keijmel, Stephan Raijmakers, Ruud
Source	Medline; PMC
abstract	Besides fatigue, many Q fever fatigue syndrome (QFS) patients also complain of frequently recurring upper respiratory tract infections with severe symptoms. We investigated whether immunologic dysregulation contributes to these complaints. Cytokine and chemokine production was measured after stimulating monocytes of QFS patients and age‐ and sex‐matched healthy controls with LPS and several viral ligands. The H3K4me3 mark of open chromatin was measured at the promoter regions of cytokines and chemokines that differed significantly from healthy controls. Monocytes of QFS patients produced significantly less TNF‐α (p = 0.032), IL‐1β (0.004, 0.024, and 0.008), IL‐6 (0.043), RANTES (0.033), IP‐10 (0.049), MCP‐1 (0.022), IL‐ 13 (0.029), and IL‐10 (0.026) than healthy controls when stimulated with various ligands. H3K4me3 expression was significantly lower in QFS patients than in healthy controls on the promoter regions of IL‐1β (p = 0.004), MCP‐1 (<0.001 and <0.001), IP‐10 (<0.001), IL‐10 (0.041), and IL‐13 (<0.001, <0.001, and 0.001). QFS patients showed diminished cytokine responses to various stimuli compared to age‐ and sex‐matched healthy controls, likely due to epigenetic remodeling and long‐term memory as a result from the acute Q fever infection. This might explain the upper respiratory tract ailments in QFS.
has issue date	2019-05-09(xsd:dateTime)
bibo:doi	10.1002/eji.201848012
bibo:pmid	31001808
has license	cc-by
sha1sum (hex)	9f4d85cf3714ac6a5717749b4ece90f2f9dc1777
schema:url	https://doi.org/10.1002/eji.201848012
resource representing a document's title	A possible link between recurrent upper respiratory tract infections and lower cytokine production in patients with Q fever fatigue syndrome
has PubMed Central identifier	PMC7163623
has PubMed identifier	31001808
schema:publication	Eur J Immunol
resource representing a document's body	covid:9f4d85cf3714ac6a5717749b4ece90f2f9dc1777#body_text
is schema:about of	named entity 'RANTES' named entity 'ligands' named entity 'UPPER RESPIRATORY TRACT INFECTIONS' named entity '004' named entity 'LPS' named entity 'STIMULATED' named entity 'VIRAL' named entity 'EXPRESSION' named entity 'LIGANDS' covid:arg/9f4d85cf3714ac6a5717749b4ece90f2f9dc1777 named entity 'fatigue' named entity 'IL-1β' named entity 'expression' named entity 'IL-10' named entity 'cytokines' named entity 'controls' named entity 'promoter regions' named entity 'Cytokine' named entity 'H3K4me3' named entity 'cytokine' named entity 'TNF-α' named entity 'IL-1β' named entity 'QFS' named entity 'IL-13' named entity 'IL-1β' named entity 'IP-10' named entity 'chemokine' named entity 'Monocytes' named entity 'monocytes' named entity 'Cytokine' named entity 'RANTES' named entity 'chromatin' named entity 'H3K4me3' named entity 'upper respiratory tract infections' named entity 'promoter region' named entity 'C. burnetii' named entity 'IL-1β' named entity 'fatigue' named entity 'histone 3' named entity 'QFS' named entity 'flu-like illness' named entity '1, 2' named entity 'ChIP-sequencing' named entity 'host cell' named entity 'methanol' named entity 'Ficoll' named entity 'TNF-α' named entity 'Internal Medicine' named entity 'Biorad' named entity 'epigenetic remodeling' named entity 'QFS' named entity 'cytokine' named entity 'H3K4me3' named entity 'QFS' named entity 'IL-6' named entity 'Arnhem' named entity 'Nijmegen' named entity 'cytokine' named entity 'Coxiella' named entity 'Netherlands' named entity 'C. burnetii' named entity 'pyruvate' named entity 'IFN-γ' named entity 'fever' named entity 'IL-13' named entity 'dsRNA' named entity 'NaCl' named entity 'infection' named entity 'long-term' named entity 'Luminex' named entity 'Epigenetic remodeling' named entity 'morbidity' named entity 'hyperosmotic' named entity 'macrophages' named entity 'cytokines'

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