About: Amelioration of COVID‐19 related cytokine storm syndrome: Parallels to chimeric antigen receptor‐T cell cytokine release syndrome

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About: Amelioration of COVID‐19 related cytokine storm syndrome: Parallels to chimeric antigen receptor‐T cell cytokine release syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Amelioration of COVID‐19 related cytokine storm syndrome: Parallels to chimeric antigen receptor‐T cell cytokine release syndrome
Creator	Hay, Kevin Chen, Luke Abdulla, Alym Biggs, Catherine Cooper Bmlsc, Jennifer Hoiland, Ryan Lee, Agnes Sekhon, Mypinder Shojania, Kamran Stukas Phd, Sophie Thiara, Sonny Wellington, Cheryl
source	Medline; PMC
abstract	Coronavirus disease‐2019 (COVID‐19) severity appears to parallel the host immune response, with a subset of patients developing COVID‐19 cytokine storm syndrome (CSS).(1) Serum inflammatory cytokines are elevated in COVID‐19,(2–5) and interleukin (IL)‐6 appears to play a central role in COVID‐19 related CSS.(6–8) Based on the success of IL‐6 receptor blockade for chimeric antigen receptor T‐cell therapy associated cytokine release syndrome (CAR T‐cell CRS), similar strategies using tocilizumab are being investigated in COVID‐19.
has issue date	2020-06-25(xsd:dateTime)
bibo:doi	10.1111/bjh.16961
bibo:pmid	32584416
has license	no-cc
sha1sum (hex)	9f4010a6b7072ccf196c0a415f041fcd2a863b73
schema:url	https://doi.org/10.1111/bjh.16961
resource representing a document's title	Amelioration of COVID‐19 related cytokine storm syndrome: Parallels to chimeric antigen receptor‐T cell cytokine release syndrome
has PubMed Central identifier	PMC7361645
has PubMed identifier	32584416
schema:publication	Br J Haematol
resource representing a document's body	covid:9f4010a6b7072ccf196c0a415f041fcd2a863b73#body_text
is schema:about of	named entity 'cytokine release syndrome' named entity 'receptor' named entity 'tocilizumab' named entity 'COVID' named entity 'cytokine storm syndrome' named entity 'COVID-19' named entity 'COVID-19' named entity '20%' named entity 'tocilizumab' named entity 'arterial pressure' named entity 'IL-6' named entity 'COVID' named entity 'CAR T-cell' named entity 'COVID' named entity 'case series' named entity 'IL-10' named entity 'IL-6 receptor' named entity 'CSS' named entity 'IL-6' named entity 'intravenous' named entity 'COVID-19' named entity 'critically ill' named entity 'COVID-19' named entity 'norepinephrine' named entity 'pg/mL' named entity 'CSS' named entity 'COVID-19' named entity 'tocilizumab' named entity 'ICU' named entity 'COVID' named entity 'CAR-T cell' named entity 'cytokine release syndrome' named entity 'tocilizumab' named entity 'inflammatory cytokines' named entity 'IL-6' named entity 'IL-6' named entity 'CAR-T' named entity 'CRS' named entity 'tocilizumab' named entity 'COVID' named entity 'IL-6 receptor' named entity 'pg/mL' named entity 'inflammatory conditions' named entity 'tocilizumab' named entity 'T-cell' named entity 'IL-1β' named entity 'invasive mechanical ventilation' named entity 'IL-6' named entity 'IL-6' named entity 'critically ill' named entity 'COVID' named entity 'CAR-T' named entity 'case series' named entity 'immune response' named entity 'tocilizumab' named entity 'CRS' named entity 'CSS' named entity 'biological plausibility' named entity 'CRS' named entity 'COVID' named entity 'COVID-19' named entity 'serum' named entity 'tocilizumab' named entity 'CSS' named entity 'IL-6' named entity 'COVID' named entity 'inflammatory markers' named entity 'COVID' named entity 'reference range' named entity 'interleukin (IL)-6'

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